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Has Accel Entertainment (ACEL) Outpaced Other Consumer Discretionary Stocks This Year?
Here is how Accel Entertainment (ACEL) and Hugo Boss (BOSSY) have performed compared to their sector so far this year.
Staff slept while patient killed at NHS mental health unit
Inquest hears how Rolando Torres-Pena, 22, was able to strangle and kill Hugo Flint-Cahan on a hospital ward in east London.
Highlights! Steveson Shakes Off Wheel Kick, Quickly Pummels Opponent
Olympic wrestling gold medalist, Gable Steveson, took a big step up in competition versus veteran slugger, Hugo Lezama, just moments ago (Thurs., Feb. 19, 2026) from inside Showcenter Complex in Monterrey, Mexico in the main event of MFL 3. Steveson’s MMA career is less than a year old, and he’s already the most hyped up […]
Hugo Ekitike injury: Liverpool boss Arne Slot gives worrying update after France international stretchered off in PSG defeat
Celtics' Hugo Gonzalez: Another strong SL performance
Celtics' Hugo Gonzalez: Another strong SL performance
Enzo Maresca working on transfer, pre-season plans ahead of Manchester City job
The Italian has already been collaborating closely with sporting director Hugo Viana for pre-season, the new campaign and beyond.
International politics expert Hugo Acha discusses Venezuelan conflict on Local 10
All eyes are on Venezuela following the capture of President Nicolas Maduro by the United States.
Philip Zinckernagel and Hugo Cuypers lead Fire in rout of Sporting K.C.
Fire score all five of their goals in the second half
Liverpool 5-2 West Ham: Hugo Ekitike shines as Reds show off new set-play prowess in important win
Is AMC Entertainment (AMC) Outperforming Other Consumer Discretionary Stocks This Year?
Here is how AMC Entertainment (AMC) and Hugo Boss (BOSSY) have performed compared to their sector so far this year.
Celtics' Hugo Gonzalez: Ruled out Saturday
Celtics' Hugo Gonzalez: Ruled out Saturday
Former First-Round Pick Named Breakout Candidate for Boston Celtics
Following Jaylen Brown’s offseason departure, the Boston Celtics will need some players to step up to fill his void next season. One particular young Celtics player has been named as a breakout candidate for the team heading into the 2026-27 campaign. Hugo González Named Breakout Candidate for Boston Celtics Greg Swartz of Bleacher Report recently […] The post Former First-Round Pick Named Breakout Candidate for Boston Celtics appeared first on HEAVY.
No, Doom maker id Software hasn't been "nerfed into the ground and gutted" by the Xbox cuts, insists director Hugo Martin
Doom and Quake creator id Software tries to reassure fans it's okay following the devastating recent Xbox cuts.
Accounts in Transit: M+C Saatchi Sport & Entertainment Lands HUGO BOSS
M+C Saatchi Sport & Entertainment is named global PR agency of record for HUGO BOSS’s brands BOSS and HUGO.... Zapwater Communications expands its relationship with Banyan Group, strengthening its role as the brand’s agency of record in North America while adding PR representation for overseas....Diffusion comes on board as PR agency of record for Pehr, a baby and kid brand spanning apparel, nursery and gear.
Palmetto Sports Daily: Latest moves in college baseball portal, SC basketball snags another foreign player
The crew discusses the latest on the transfer portal for college baseball, and the Gamecocks men’s basketball team snags Hugo Lopez from Spain.
Anna Kendrick Is “Over the Moon” About Directing ‘The Seven Husbands of Evelyn Hugo’
The 'Babies' actress covered George Clooney, 'Twilight' ("what the f*** am I doing here?") and 'Pitch Perfect's "revisionist history" in a career-spanning conversation at the Zurich Film Festival.
It's confirmed: Electric striker ready to join Liverpool squad
Liverpool have a fantastic striker ready to join their first-team squad. It’s time, that much is clear.Liverpool are low on strikers right now. Hugo Ekitiké's injury has them down to just the one e...
Arbeloa on new signings, Tete and pressure of tough start
Fulham boss Alvaro Arbeloa has been speaking to the media before Saturday's Premier League game against Crystal Palace at Craven Cottage (kick-off 15:00 BST). All players are available except for Tom Cairney. Arbeloa confirmed deadline-day signings Hugo Larsson, Manuel Angel and David Affengruber will be in the squad but are not ready to start, adding: "Be patient with with these three players - they need to understand what we want from them."
MFL 3: Gable Steveson vs. Hugo Lezama LIVE stream
Follow along live for Gable Steveson’s third MMA fight at Mexican Fight League 3
‘Penchant for bling’: can Sports Direct’s Mike Ashley take a bigger slice of luxury retail?
Frasers billionaire bought Harvey Nichols and increased Hugo Boss stake despite tough times for high-end stores
Edinburg Chamber Announces Business Conference Featuring Emmitt Smith
Texas Border Business By Roberto Hugo González / Texas Border Business The Edinburg Chamber of Commerce announced that former professional football player Emmitt Smith will serve as the keynote speaker for its upcoming business conference, “The Business Playbook,” scheduled for April 23, 2026, in Edinburg, Texas. The announcement was made during a press conference held […]
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
I left the business I founded to paint full time
Victoria Hugo left her social media business to start an art hustle, doing commissions of famous cities and places, painted on boarding passes.
An 8-year-old boy's backyard discovery literally changed science forever
One summer day, 8-year-old Hugo Deans spotted a cluster of tiny, BB-sized spheres (galls) near an ant nest in his backyard.
Humanities Center and CAAPP welcome science fiction writer Nnedi Okorafor
The Pitt Humanities Center and Center for African American Poetry and Poetics will host Nnedi Okorafor, a Nigerian-American writer of science fiction and fantasy, for a weeklong seminar from May 4 to 8. Okorafor will discuss the work of fantasy and how dreaming of other worlds helps us survive this one. She is best known for her Binti Series, a trilogy of African-futurist science fiction novellas. She has won the Hugo, Nebula, Eisner and World Fantasy awards and was inducted into the Science Fiction Hall of Fame. Her most recent novel, “Death of the Author,” was heralded by the New York Times as
Chicago Fire striker extends ridiculous MLS goalscoring streak 📈
Chicago Fire striker Hugo Cuypers is on an absolute tear in MLS this season. The Belgian is on pace for a historic season after bagging his 13th goal of the campaign this afternoon against CF Montré...
Hugo Souza shines as Corinthians end RB Bragantino’s unbeaten run
Corinthians bounced back after their debut defeat in the Brasileirão.Playing in front of their faithful fans for the first time in the competition, Timão defeated Red Bull Bragantino—who had been ...
Liverpool v Man City: Team news
Liverpool boss Arne Slot names the same starting XI from the side that beat Newcastle 4-1 last time out. It means the in-form Hugo Ekitike leads the line supported by Florian Wirtz, who is beginning to find his feet in a Reds shirt. Manchester City boss Pep Guardiola makes five changes to the side that beat Newcastle in midweek to reach the Carabao Cup final.
Which Young Player is Most Exciting For Boston Celtics?
Baylor Scheierman? Hugo Gonzalez? One of the draft picks?
Celebrate Amazing Stories and Science Fiction’s 100th Birthday
Doors Open 7:15 p.m. Celebrate Amazing Stories and Science Fiction’s 100th Birthday with us! In April 1926, Hugo Gernsback published Amazing Stories magazine for the first time, and while the name of the genre took a few more years to become a household term, many credit this moment with the birth of Science fiction fandom as we know it today! Join us for a two-panels featuring a discussion on the impact of Amazing Stories and Science Fiction as a genre! Featuring published authors, scholars, and podcasters with deep knowledge of the history and great works of the last 100 years. The second panel will be a how-to guide for writing your own Science fiction stories or novels, including teachers, authors, and scholars of the genre. Verbatim Books on Facebook / Instagram
Exciting forward closing in on Liverpool as major deal agreed
An exciting forward is closing in joining Liverpool's first-team very soon. One thing Andoni Iraola has a shortage of is adequate options at senior level in the no.9 position.With the injury of Hugo E...
Coroner warns of risk of future deaths at mental health unit where patient was killed
Hugo Flint-Cahan, 34, was fatally attacked by Rolando Torres-Pena, 22, at a mental health trust in east London.
🚨 Official: another star pulls out of the World Cup!
Another withdrawal for the World Cup!After Hugo Ekitiké, Serge Gnabry and Rodrygo, another star has officially withdrawn from the 2026 World Cup!Injured this Saturday on the Wolverhampton pitch with ...
Liverpool have another Hugo Ekitike and he's special
Liverpool have another exciting attacker who is special and who could be another Hugo Ekitike. It has been a disappointing transfer window for the Reds, which has put a lot of pressure on the Frenchma...
Leonardo’s owner expands into the restaurant business with Pa'l Corazón
Hugo Leonardo came to the United States from Mexico in 2001 as a teenager, working his way through various kitchen positions in Park City until he opened his own market and taquería — Leonardo’s — four years ago to provide specialized goods to Park City’s Hispanic community. But Leonardo says his latest business venture, a Mexican restaurant in the heart of Kamas, is a lifelong dream that has finally come to fruition.
Board of Health wields unusual power, expert tells members
Marblehead’s Board of Health has powers unlike virtually any other local board or commission in Massachusetts, a public health attorney told members Monday night — including the authority to adopt regulations that carry the force of state law. Michael Hugo of the Massachusetts Association of Health Boards spent more than two hours walking the board
IShowSpeed Set for Huge Stream With Liverpool Star Hugo Ekitike
Hugo Ekitike is reportedly teaming up with IShowSpeed, as the Liverpool striker prepares to swap Premier League pressure for the unpredictable world of Speed.
Web reacts to Otávio's display in Brazil win; see reactions
Brazil had to dig deep to beat Australia 4-2 this Tuesday (29) in a friendly in Brisbane. On social media, goalkeeper Otávio’s performance, as he played in place of Hugo Souza, sparked a debate ove...