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Padres Veteran Reliever Makes $4.45 Million Contract Decision
Veteran left-hander Wandy Peralta has exercised his $4.45 million player option for 2027, keeping him in San Diego for a fourth season.
You might be neglecting the one thing that keeps your PC healthy
Windows offers Disk Cleanup, easy app uninstalls and Storage Sense, but Microsoft PC Manager did a more thorough job freeing up storage space in our tests.
Popular Bone Builders boosts strength, fights osteoporosis
Exercising helps “keep her bones strong,” said two-time cancer survivor Beverly Lewis.
CONFIRMED lineups: Racing Santander vs Real Madrid, 2026 La Liga
Real Madrid have published their starting lineup for the upcoming match against Racing Santander in La Liga. Los Blancos made a statement with their impressive 1-2 win in El Clásico and will want to keep their good form and momentum going against a solid home team like Racing. STARTING LINEUPS Racing Santander starting XI (TBC): […]
AI Slop Threatens Trust in Science
AI can fake a plausible paper at the push of a button. Can detection tools and peer review keep up?
NFL keeps fining Caleb Williams for refusing to cover logo of "science" cleats worn by over 80 players
Caleb Williams has been fined $35,823 for wearing Caddix "science" cleats, but the Chicago Bears quarterback refuses to cover the logo or stop wearing them
NFL keeps fining Caleb Williams for refusing to cover logo of “science” cleats worn by over 80 players
The Chicago Bears quarterback refuses to cover the unauthorized Caddix branding and has appealed his initial fine
17 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Make Your Nitrogen Plan Do More With Less
The cost and supply of traditional N are in constant flux. Pivot Bio PROVEN® G3 keeps farmers locked in. Results from 130+ trials are proving it.
Serie A official line-ups: Como vs. Venezia
Jean Butez keeps his place in the Como goal and Samuele Ricci returns to midfield, while Lion Lauberbach and Gianluca Busio come in for Venezia.It kicks off at 12:30 CET [11:30 GMT] at the Stadio Gius...
5 Reminders to Help Protect Your Business from Holiday Fraud
Before the holiday rush, help your team spot suspicious emails, verify payment requests and keep safeguards in place.
Keeping Hawai‘i Healthy 2026
Hawaiʻi’s health care systems are proudly rooted in traditions of providing quality care and cutting-edge treatments for their patients across all islands.
Keeping Hawai‘i Healthy 2026
Hawaiʻi’s health care systems are proudly rooted in traditions of providing quality care and cutting-edge treatments for their patients across all islands.
This Republican Wants Voters to Consider a Post-Trump World
John E. Sununu, the Republican Senate candidate in New Hampshire, has the president’s endorsement but is keeping him at arm’s length.
Opinion: It’s been decades since Kansas made a difference in national politics. This time it means the world.
Opinion from Max McCoy: This year's U.S. Senate race in Kansas is a referendum on what may be the most corrupt administration in American history — and a repudiation of the phalanx of legislative quislings that keeps it in power.
Bath find their feet to keep Sale out
AFTER suffering three consecutive defeats, Bath showed much improved form to record a bonus-point victory over a battling Sale before a sold-out Rec. ■By ROGER PANTING Bath .................................... 36pts Tries: Arundell 3, de Glanville 22, Cokanasiga 30, 42; Hennessey 64 Conversions: Russell 3, 22, 42, 64 Penalty: Russell 58 Sale Sharks ..................... 28pts Tries: Jibulu […] The post Bath find their feet to keep Sale out appeared first on The Rugby Paper .
‘Heart dropping’: Bride says Metro Detroit mobile bartender won’t refund after selling business
For weeks, Local 4’s Kyla Russell has been hearing from brides who say they were ghosted by wedding vendors on their big day. One name that keeps coming up: Sip of Eden, a mobile bartending service based in metro Detroit.
Business Owners Have a Window. Most Aren't Ready to Use It. by Tully Ryan
I spend my working life on both sides of a business sale. As an M&A advisor based in Wilmington, I help lower middle market owners across North Carolina, South Carolina and Virginia sell what they've built. As the founder and CEO of IQExit, I work with the bankers, wealth advisors, CPAs and attorneys who sit beside those owners for years before a sale ever comes up. From both seats, I keep seeing the same thing. The market is ready for our owners. Too many of our owners aren't ready for the market. Start with our own backyard. Wilmington's metro area added more than 12,000 residents between July 2024 and July 2025, a 2.6% jump that ranked seventh in the country. It also posted the highest job growth rate of any metro in North Carolina. I see the same pattern in the growth markets I work in across the Southeast. New residents mean new customers and new workers. They also mean new buyers: people who moved here from corporate jobs and want to own something, private equity groups looking for add-ons in HVAC, electrical, landscaping and other trade services, and younger entrepreneurs who would rather buy a running business than start one from scratch. The ownership numbers are hard to ignore. About half of North Carolina's small businesses have an owner who is 55 or older, and roughly 85% of those owners have no succession plan, according to the North Carolina Employee Ownership Center. Nationally, more than half of Baby Boomer business owners have no documented transition plan. That isn't a crisis yet. It's a timing problem. A lot of businesses will change hands over the next decade, and the prepared ones will get the better buyers and the better terms. Buyers have money and they're using it. But an active market doesn't mean a fast one. The IBBA's latest Market Pulse survey found that Main Street deals took six to 10 months from engagement to close in the second quarter, and lower middle market deals took 11 to 12 months. That clock starts after the owner decides to sell. In my experience, the real preparation has to start years before. Two clocks, two playbooks When I sit down with an owner or their advisor, my first question isn't “What's it worth?” It's “When?” The answer puts the owner in one of two groups. If the owner wants out within 24 months, we're in execution mode. There's no time to rebuild the business. The work is cleaning up what a buyer will test: three years of financials that tie to the tax returns, an add-back schedule you can prove, customer and vendor contracts in writing, a lease that can be assigned, and a price the market will actually pay. The goal is certainty to close. If the exit is two to five years away, the owner has something worth more than time. They have choices. That window is where most value gets built, and most owners waste it by waiting. What kills deals In the lower middle market, deals rarely die over the headline price. They die in diligence, or they get retraded late in the process. I see the same causes again and again. The owner is the business. If every key customer relationship runs through the owner's cell phone, a buyer sees risk and a lender sees more of it. The books don't hold up. Buyers spot weak accounting fast. Statements that get revised mid-process, a revolving door in the bookkeeper's chair, revenue tracked on a side spreadsheet, and margins that slip while sales climb with no clear reason all make a buyer nervous. So does an owner who pushes back when asked for documents. And plenty of private owners run personal expenses through the company. Add-backs are normal. Add-backs you can't document turn into a lower offer. The real estate isn't sorted out. Many owners hold their building in a separate LLC. That's fine, but the lease terms or the property sale should be settled before a buyer shows up, not halfway through diligence. Revenue sits in too few hands. Picture a contractor with 40% of its work coming from one builder, or a service company running on handshake deals. Buyers will still look, but the terms shift toward more seller financing, an earnout, or less cash at closing. Owners and advisors: if your exit is three to five years out • Get a baseline now. Find out where the business really stands today: what a buyer would pay, who that buyer is likely to be, and which gaps would hurt you in diligence. You can't fix what you haven't measured, and the answer is often different from what the owner expects. • Make yourself less necessary. Spend the next few years building a manager or small team that can run daily operations and own customer relationships. Put handshake deals into written contracts. A business that runs without its owner is worth more and is far easier to finance. • Clean the books for three straight years. Buyers and lenders look back at least three years. Separate personal expenses, keep the financials tied to the tax returns, track every add-back as you go, and settle the real estate plan early. A word to CPAs CPAs often see a sale coming before anyone else, and you're usually the most trusted voice an owner has. Year-end meetings are the right time to start this conversation. Here's what I'd ask every CPA to do this season with business owner clients over 55: • Ask the timing question. “Do you see yourself owning this business in five years? If not, who takes it over?” Write down the answer and bring it up again at next year's meeting. • Run a proof of cash and review revenue recognition. Make sure the cash in the bank ties to the revenue on the books. Pay close attention to contractors with work in progress and to companies selling memberships or service plans. These issues are easy to fix with years of lead time and painful to fix a month before closing. • Pair the tax return with an exit readiness review. Invite clients to complete IQExit's Exit Readiness Intelligence (ERI) process as part of year-end planning. It gives you and the client a shared picture of readiness gaps and an indicative value range, and the results come back to you as the advisor. That turns a tax meeting into a planning relationship, and it puts you in position to bring in tax and M&A help early, when choices like purchase price allocation can still save the client real money. Changing the conversation For bankers, wealth advisors and attorneys, the hard part is raising the subject without seeming to nudge a client toward the door. I understand that. Nobody wants to tell a 60-year-old owner it's time to sell. So don't. Ask a different question: “If a buyer called tomorrow, what would they find?” That's a planning question, not a pitch, and it's useful whether the exit is two years out or 15. It's the question we built IQExit to help advisors answer. Whether you're in Wilmington, Raleigh, Charleston, Richmond or anywhere else, owners have a real opening right now. The buyers are out there and so is the capital. The owners who come out ahead will be the ones who start getting ready before they're ready to sell.
The Best Time to Fix Your Business Is When Things Are Going Well by Nathan Tayloe
There's a pattern I've noticed working with growing businesses over the years. Conversations about what needs to change rarely happen when things are going well. They tend to happen when growth slows, a competitor starts winning business, or something that used to work stops producing the same results. By then, the decisions are often harder, more expensive, and more urgent than they needed to be. It's understandable. When revenue is growing, customers are coming in, and employees are busy, there's little incentive to question what's working. Leaders have plenty to manage without creating new challenges for themselves. Running my own business has taught me that it's easy to get caught up in what's happening today and put off improvements you know will matter tomorrow. Those periods of success may actually be the best opportunity a business has to make meaningful improvements. When Success Makes Change Less Urgent Most businesses have things they know could be better. The challenge is finding a compelling reason to address them when everything appears to be working. Maybe the company has outgrown its original positioning. Perhaps internal processes haven't kept pace with growth, or the customer experience has become inconsistent as the organization has expanded. These issues don't necessarily prevent a business from growing. Strong demand can make them easier to overlook, especially when teams are focused on keeping up with the work already coming in. Over time, small inefficiencies become accepted ways of operating. Outdated processes remain in place because they've always worked well enough, and opportunities to improve get pushed aside in favor of more immediate demands. The business continues moving forward, but some of the things supporting that growth aren't getting stronger along with it. The Advantage of Acting Early When a business is performing well, leadership has something valuable: options. There's more flexibility to invest, experiment, develop people, and make thoughtful decisions without the pressure of an immediate problem that needs solving. Compare that with trying to make the same changes when revenue is declining, or the market has shifted. Investments become harder to justify, timelines get compressed, and decisions that could have been made strategically become urgent responses to circumstances. I've seen businesses postpone improvements for years because there was never a particularly good time to address them. Eventually, circumstances decide for them, often when they have fewer resources and less flexibility to respond. Growth Changes What a Business Needs This is especially relevant in a growing market like Wilmington, where new businesses, new residents, and continued investment are creating opportunities across the region. As organizations grow, the expectations placed on them change. Customers expect greater consistency, employees need clearer processes and opportunities, and leadership has to make decisions that support a larger, more complex business. What worked when a company was smaller may still work today, but that doesn't necessarily mean it will support where the organization wants to go next. Sometimes the most valuable improvements are the ones that prepare a business for demands it hasn't experienced yet. That might mean: Strengthening internal processes before they become bottlenecks Developing leaders before the organization depends on them Improving the customer experience before inconsistencies affect retention Revisiting positioning before the market outgrows the company's story None of these changes requires a crisis. They require recognizing that a growing business needs to keep evolving, even when current performance gives leadership little reason to worry. Use the Good Years Wisely Successful businesses don't need to constantly reinvent themselves. There's value in knowing what works and having the discipline to build on it. There's also value in occasionally asking whether the business is as strong as its current performance suggests. Are there problems we've learned to work around instead of solving? Are we still operating the way we did several years ago, even though the business has changed? What would we improve today if we weren't waiting for something to go wrong? Success creates the freedom to ask those questions and act on the answers. The businesses that make the most of that opportunity are often better prepared for whatever comes next. The strongest businesses don't need a crisis to recognize an opportunity to improve. They use the good years to prepare for the years ahead. — Learn more about how we help organizations strengthen their positioning, align their strategy, and prepare for what's next at tayloegray.com, or reach out directly at nathan@tayloegray.com.
Galaxy rout Austin FC to keep alive playoff hopes
Joao Klauss scores his 10th goal of the season early to help L.A. take control and Marco Reus contributes three assists in the victory.
US Senate candidate El-Sayed wants Democratic rival to stay away, source says
NEW YORK, Oct 31 (Reuters) - US Senate nominee Abdul El-Sayed wants to keep his distance from US Representative Haley Stevens, who he defeated in the Michigan Democratic primary in early August, amid ...
Bitcoin's white paper turns 18, and small businesses are still paying for the bailouts it answered
Eighteen years after Satoshi published the Bitcoin white paper, business owners are still covering the cost of a system built on bailouts, and they can protect part of their surplus by keeping it in bitcoin, argues Onramp CEO Michael Tanguma.
Apple Watch Ultra 4 Hits All-Time Low Price With Amazon's $99 Discount
The Apple Watch Ultra 4 has dropped to $699.99 on Amazon, down from $799.00. This is a match of the all-time low price on the new Ultra 4, which just launched in September. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Gamethread: Boston College vs Duke
Happy Halloween folks. We’re down in the Blue Devil’s den. The Eagles are riding a two-game win streak are itching to keep the good times rolling. The big news of the week of course was that star tight end Kaelen Chudzinski would be available and considered a ‘game-time decision’ from O’Brien earlier.It’s unreal. Sounds like […]
Susan Collins Is Always Keeping Score
The long-serving senator has delivered millions of dollars to every corner of her state. But in Maine, people say, it’s best to avoid getting on her bad side.
5 Ravens to zero-in on vs. Bills
Baltimore needs a win this week to keep pace in the crowded AFC playoff race
Confirmed Man United XI vs Chelsea
Manchester United visit Chelsea today for a 12.30pm kick-off in the Premier League.Here is the confirmed line-up for the game.Goalkeeper and DefenceSenne Lammens is in goal.Leny Yoro is the right-back...
Greg Abbott Runs the GOP’s Top Political Machine. Can It Keep Texas Red?
The country’s longest-serving governor is trying to notch another victory for the GOP — and himself.
Credit card advocates argue using plastic for Halloween purchases saves businesses money
'Those savings help keep Halloween affordable for families.'
🚨 Breaking: medical update on Valencia's goalkeepers
Valencia CF goalkeeper Kayne Van Oevelen suffered a sprain in his right knee during Friday's training session at the Ciudad Deportiva de Paterna, Valencia have confirmed. "The Valencia goalkeeper w...
You got to kinda keep your composure. And I remember …
You got to kinda keep your composure. And I remember …
“It’s The Kobe Bryant Thing” – MLB Insider Reveals Behind-The-Scenes of Shohei Ohtani’s Controversial Decision During NLCS
MLB insider Jim Bowden shared details about the Los Angeles Dodgers’ decision to keep Shohei Ohtani in the lineup despite fitness concerns during the 2026 National League Championship Series. Ohtani’s availability became a major talking point during the series against the Milwaukee Brewers.
Flooding sends water into Arts District small business shops
Business owners and neighbors worked to keep shops open near Commerce and Imperial
Flooding sends water into Arts District small business shops
Business owners and neighbors worked to keep shops open near Commerce and Imperial
Flooding sends water into Arts District small business shops
Business owners and neighbors worked to keep shops open near Commerce and Imperial
Flooding sends water into Arts District small business shops
Business owners and neighbors worked to keep shops open near Commerce and Imperial
Flooding sends water into Arts District small business shops
Business owners and neighbors worked to keep shops open near Commerce and Imperial
Flooding sends water into Arts District small business shops
Business owners and neighbors worked to keep shops open near Commerce and Imperial
WhatsApp announces four new features to make group chats easier to manage
In a blog post this week, WhatsApp confirmed that it is rolling out four new features designed to make it easier to manage group chats and keep track of what’s going on.
Judge orders 3 taxpayer-funded Trump administration ads to be pulled from TV, social media
The federal government must pull three taxpayer-funded Trump administration ads that appear to have been made for political or propaganda purposes, including one touting the president’s claim that every American will get $5,000 if Republicans keep control of Congress in the upcoming election, a judge ruled Friday.
Rockets Exercise Reed Sheppard's Fourth Year Team Option
The Houston Rockets have exercised Reed Sheppard's fourth-year team option to keep him in Houston for the 2027-2028 campaign and potentially extend him later down the line.
Famed group’s music coming to Modesto’s Gallo Center. When the stage will heat up
The group keeps alive the music of the original Buena Vista Social Club.
Scaring Up Customers for Halloween Streaming
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Way back in 2022, I did a deep dive into each streamer’s horror offerings, looking at the top horror film and TV shows, and which streamers had the best library titles and best Halloween landing pages. If you’d like to check out those articles... Way back in 2022, I ranked all the streamers’ Halloween landing pages. I updated my thoughts in 2023... ...and 2024. After taking last year off, I’m back at it again this year. My theory—then and now—is that Halloween landing pages provide a subtle but surprisingly valuable insight into how the streamers position themselves, and what they do well and what they don’t. They show who relies on libraries, whose libraries across TV and film have the most value, who understands how customers want to access those libraries, and, being blunt, which product teams actually put the time in to make a quality holiday user experience. Plus, three “horror” TV shows had big debuts this month! So today, I’ll answer the questions... What are the all-time biggest horror shows and films on streaming? What streamer has the best library? What streamer has the best landing page? And what does this say about the streaming wars today? But first, let’s look at three big new horror shows on streaming... Subscribe Horror TV Has Dominated October So Far In a fun twist this month, three different streamers released three different horror TV shows. Many scary stories come out every October, but the twist is that all three did well: Two of the shows got over 20 million hours, which is just good. You can see that Below is helping Netflix start October/Q4 off well: And that Carrie is a top seven show for Amazon through two weeks: But here’s the crazier note: even though it doesn’t look huge, Crystal Lake is Peacock’s biggest debut yet: Let’s discuss the streaming elephant in the room: two of these shows are based off classic horror IP: Jason and Carrie. So once again, IP works, in theaters and on streaming. It just does. Oddly enough, horror IP doesn’t draw a tenth of the ire that other IP does, even though, arguably, horror films are the original franchise films, starting in the 1930s and continuing on through the slasher film 80s. So horror TV shows are off to a great start. While I’ve written before that horror films do NOT over-perform on streaming, TV shows are a different story. The Top Horror Films and TV Shows on Streaming All Time To start, here are the top first seasons for all streaming TV shows since 2020 (the start of the Streaming Ratings Era): First take: yep, that’s some power laws at work right there. The biggest TV show hits aren’t just bigger than other hit shows, they’re orders of magnitude bigger. Wednesday dwarfs The Last of Us (a big hit!) and is ten times bigger than the next six most popular horror shows. Wow! So yes, horror or horror-adjacent shows can do as well as the top shows on streaming. Wednesday is proof of this. (Though, even Wednesday is more horror-adjacent than proper horror.) Also, note that Below, Carrie and _Crystal Lake_could/should keep moving up the charts. That said, there is some weakness in these numbers. Only eighteen horror first seasons made the charts, which is low. For context, 541 season ones have made the Nielsen originals charts since 2020. Eighteen out of 541 isn’t great! Plus, again, the IP issue. Wednesday and The Last of Us came from popular IP, and It: Welcome to Derry and Goosebumps are spinoffs. Next up, every horror show from season two on: The bad news here? Besides one iconic example, horror shows don’t last long i.e. generate very many seasons. While many straight-to-streaming horror shows were limited series, many weren’t and only four horror shows got to a second season or beyond. That’s a bad hit rate. And yeah, only one horror show made it to a fifth season! This genre is just not elite (on streaming). Okay, on to the top horror films all time (er, since 2020): We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… ...What streamers have the most horror films... ...And how FASTs have embraced horror films... ...How many elite horror films are on linear TV or aren’t on TV at all… ...How streamers make it very, very hard to find horror films… …And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Chris Sutton Slams Mistake Martin O'Neill Keeps Making
Chris Sutton has slammed a mistake that Martin O'Neill constantly keeps making, which is hurting Celtic.
'Crypt Jam': Unearthing the Crypt Keeper’s 1992 hip-hop hit
With the Crypt Keeper back to host AMC’s FearFest 2026, the Halloween season offers a reason to revisit “Crypt Jam,” his 1992 hip-hop deep cut.
How “Zombie Bacteria” Keep Making DNA Even When They’re Dead
Anyone looking for last-minute costume ideas for Halloween, we’ve got you sorted.
'Star Trek's' William Shatner and George Takei honor the death of Walter Koenig
'Rest well, my dear friend. Keep navigating a steady course.'
Exclusive Preview: The Lab Press releases portable editions, including SUPER SCIENCE VOL. 1
The Lab Press launches portables of ogns like Super Science Volume 1 that keep the quality of their signature designs intact
Hemp businesses ahead of elections
Hemp business owners in Texas say they are struggling to keep their doors open.
Clemson animal health officials: keep domestic birds away from wild waterfowl and their waters
The call comes as waterfowl take wing along the Atlantic Flyway and migrate south to overwinter, carrying with them diseases such as Highly Pathogenic Avian Influenza (HPAI).
Science Begins With Wonder and Sometimes With a Salamander.
The Bar Harbor Story is generously sponsored by the Don & Beth Straus Center at Birch Bay Village. BAR HARBOR—The children had come to see the axolotls, those odd little salamanders with pink frills around their heads and the remarkable ability to grow back what they lose. But also there were stickers. There were crafts. There was the kind of excitement that makes a roomful of kindergarteners forget, for a little while, that sitting still is ever a requirement. And then there were the animals themselves, alive in their clear cases at the MDI Biological Laboratory, where 12 children from Pemetic Elementary School got to meet the creatures they had been learning about in class. “Do you love them?” their teacher, Carol Null, asked. The answer came back in a chorus. “I do!” “I do!” “I do too,” Null said, smiling. “I love them even more now.” That was the thing about a day at the lab. Science was no longer a picture in a book, or a word on a classroom wall. It had a face, a tail, and a set of extraordinary powers. And for a child, sometimes that is where wonder begins. Sometimes learning about science is about stickers. Sometimes it’s about bright pink feathers and getting super excited about that glow in the dark. Sometimes learning about science is joy—pure and simple joy. That’s how it was October 28 at the MDI Bio Lab as Miss Hannah (known in the lab as Dr. Hannah Lust, director of STEM, undergraduate and graduate Training), other scientists, graduate students, and MDI Bio Lab staff, hosted 12 students from Carol Null’s Pemetic Elementary School’s kindergarten class. The 2.5-hour program created by Dr. Lust focused on axolotls, a species of mole salamanders, a superhero in the animal world: a superhero with some scientific-study worthy superpowers. One of those superpowers come from the axolotls’ ability to regenerate body parts, including entire limbs. But also, they’re cute. This fall, before coming to the internationally renowned lab nestled in Salsbury Cove, Null has been integrating axolotls into her class. They’ve been part of the kids’ vocabulary and their storytelling. They’ve been part of science. They’ve been part of the children’s learning about facts vs opinions. The Pemetic Elementary kindergarten students learn about invasive species and the impact on the ecology and one student related it to their dad, who lobsters, and his worries about green craps, an invasive species in Maine. “Are they bigger or smaller than you thought they’d be?” the children are asked after the scientists show them multiple see-through cases of axolotls, lined up on a table that they’re told not to jiggle. “Bigger!” “I think they’re bigger.” “Smaller!” The bio lab opening its doors to the collaborations and to students and families is a norm, but this is the first program of this kind. It’s meant to encourage kindergarten students about axolotls. But when the students come to the bio lab something else happens too—something beyond Null’s child-focused teaching—the students see science—and the regenerating creatures in real life. They do crafts. They speak with them. They meet people who know all about them: scientists and educators who talk to the kids like they’re equals. That’s a superhero power, too. Null speaks about meeting the kids where they’re at in her classroom, letting their interest and hearts lead her in their learning. That requires recognition of interests, of individuality, of empathy. Some would argue that’s a super power, too, but it’s also in those 12 students as they listen to the storybook, encounter those live axolotls, and hear about how axolotls might help advance society’s understanding of human health. As Eddie Seckeler (comparative animal models, CORE facility manager), carefully puts the axolotls on a cart and rolls them away, some of the children stop what they’re doing to watch. “Bye axolotls.” “Bye!” “Bye!” The axolotls are not just images in a book, Hello, I’m an axolotl by Hayley and John Rocco; they are real and cool. MDI Biological Laboratory scientists Dr. Prayag Murawala and Dr. James Godwin who both feature in the Roccos’ book. The kindergarteners get to meet them in real life, off the page, in the world, doing science. They learn from them, laugh with them. “The visit is about more than meeting an unusual animal. By introducing children to scientists working in their own community, the experience helps make science tangible and accessible. Students can see that science is not just something they read about in books or learn about at school. It is something real people do every day by asking questions, making observations and working to understand how the world works,” explains MDI Biological Laboratory Director of Communications Rebecca Woods. While the students make axolotl-related crafts around tables, graduate students and staff help out. Ryan holds up his construction paper setting and axolotl to show Omar Maged, a graduate student. “Do you like it?” Ryan asks, eyes wide, turning from his axolotl to look up at Omar. Omar studies the construction paper for a moment, smiles and says definitively, each word important. “It is beautiful.” Null says that she’s so thankful for all the “amazing” community partners that her school and her students get to interact with as they learn and grow and live, but emphasized how the MDI Bio Lab goes out of its way to create something meaningful, something that allows her young students to build their own agency, to know that they can be impactful in their community, to show them how how things they learn about in text is connected to themselves and their community. Woods explains, “Axolotls have an extraordinary ability to regenerate, or regrow, certain body parts, including limbs. Scientists study these animals to understand how regeneration works and what their biology might teach us about tissue repair and healing in humans.” The children enter the space for “a memorable introduction to a big scientific question,” Woods said. “How can some animals regrow body parts? The encounter encourages children to look closely, wonder about what they see and begin to understand how scientists use observations and experiments to investigate questions.” “For the students, the visit is an opportunity to explore a fascinating animal and meet scientists in their own community,” Woods explains. “For MDI Biological Laboratory, it is a chance to share the excitement of research, nurture curiosity, and help young learners discover that science begins with asking questions.“ At the beginning of the school year, Pemetic kindergarteners didn’t know what the axolotl was—at least not exactly—now they know all about the axolotl’s life cycle. “It’s different than a butterfly,” one student told Mrs. Null. It is. The change and knowledge might seem small**,** but it offers a glimpse of what happens when a subject moves beyond the pages of a book and into a child’s world. The children have been learning about butterflies at the Charlotte Rhoades Park and Butterfly Garden. At both the garden and the MDI Bio Lab, the children see the animals, meet the scientists who study them and at the lab encounter a question that researchers are still working to answer: how can some creatures regenerate body parts, and what might that teach us about healing in humans? They leave with gift bags, paper-plate salamanders, new things to wonder about and a connection between the science they learn in school and the work happening in their own community. The axolotls may be remarkable for their ability to grow back what they have lost. For these young students, the day offers something different: a chance to discover how much there is to ask, observe, and imagine. When Null’s students had time to use chalk and draw whatever they want, in the beginning of the year, they drew rainbows. Now? They’re using that chalk and choosing to draw axolotls instead. About MDI Bio Laboratory For more than 125 years, MDI Bio Lab has been a center for training and research in comparative biology. In the last two decades its biomedical research has focused on aging, regeneration, and environmental toxins. The Laboratory houses 11 research groups staffed by an international team of world-class scientists and graduate students. It also leads a statewide network of colleges, universities and research institutions that collaborate to provide training, research experiences and financial support to help young Mainers play a bigger role in today’s biomedical revolution. Located on Maine’s rugged coast, the Laboratory’s 100+ acre campus houses research facilities, cottages and dorms that house visiting scientists and students. It is also home to MDI Bioscience, a subsidiary working to design innovative techniques to speed the drug discovery process. The Bar Harbor Story is generously sponsored by Rick Osann Art. LINKS TO LEARN MORE NIH INBRE MDI BIOLOGICAL LABORATORY Pemetic Elementary School Hello, I’m an Axolotl Photos: Carrie Jones/Bar Harbor Story HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment
Wall Street Journal columnist visits FSU, talks post-midterm politics
As parties keep a close eye on the 2026 midterm, conservative columnist Kimberley Strassel addressed the future of American politics after November.
America's Enduring Strength is Bigger Than Politics
On Election Day on Tuesday, Americans will cast their final ballots in the 2026 midterm elections. Regardless of who wins, free enterprise is what will keep America moving forward.
Want to Lose Weight? Why Mixing Cardio And Strength Training Beats Any Single Workout
FRIDAY, Oct. 30, 2026 (HealthDay News) — Searching for the single best workout to help you lose weight? There isn’t one, a sports medicine doctor says, because the smartest approach is mixing different types of exercise. Switching between workout styles keeps the body challenged, which helps it keep ...
Tech giants need legacy businesses to keep growing as they pour trillions into the AI buildout
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Opinion: We can keep the Bears in Chicago. Here’s how.
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DataFi Donation Ceremony at the Ministry of Health-Remarks by ADCM Steve Bremner
DataFi Donation Ceremony at the Ministry of Health Remarks by Acting Deputy Chief of Mission a.i. Steve Bremner (…) I’m pleased to join the Ministry of Public Health and our implementer, Palladium, today to hand over IT equipment including 80 laptops, 300 tablets, and Monitoring and Evaluation reporting tools for CSBII. Good health decisions start with good data. When a health worker in a remote commune notices unusual fever cases, that information must reach district and national teams fast. Every hour counts. Fast, reliable data helps the Ministry detect an outbreak early, send teams where they’re needed, and stop a disease before it spreads. These laptops and tablets will help do exactly that. They’ll strengthen Madagascar’s health information system and disease surveillance so health workers can collect, report, and use data faster and more accurately. This support reflects the America First Global Health Strategy. Under this strategy, the United States works directly with partner governments based on country ownership, shared investment, and accountability for results. Together, we’re strengthening Madagascar’s ability to detect and respond to outbreaks quickly though the MOU signed in December 2025. This work protects Malagasy families and the American people. Today also marks a transition. The Data.FI project is ending, but the work will continue. Palladium will continue to carry these same activities forward through a new project, AFGHS Palladium, under the State Department’s Bureau of Global Health Security and Diplomacy. The new project will put an even stronger focus on results. Mister SG, your ministry’s close collaboration with Data.FI made today possible. I hope you will bring the same commitment to this new project. Together, we can deliver even greater results and speed up the transfer of skills to Ministry teams. Our shared goal is to build the ministry’s capacity to lead, manage, and sustain these systems on its own. That is Madagascar’s path to self-reliance. Equipment alone doesn’t stop an outbreak. People do. To the health workers and data managers who will use these tools: thank you for your dedication. To the Ministry: we count on you to put these devices to work quickly, keep them in good condition, and protect the data they hold. That’s how this investment will deliver results for years to come. The United States stands with the Government of Madagascar. We commend the Ministry of Public Health for its leadership. We look forward to continuing our collaboration through AFGHS Palladium and beyond. Thank you. Misaotra betsaka.
Why healthcare has become such a big problem for Republicans
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‘This can’t keep happening’: How divorced military spouses get trapped in foreign countries
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Bulkeley: We need to keep religion out of politics
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The chemicals that keep us cool leave something behind
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Alexander Isak: Why keeping Sweden striker fit and firing is key to Andoni Iraola's Liverpool revival
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How video game remakes tap the power of nostalgia
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700 GB in 15 seconds: Smart system helps scientists keep pace with atom-scale microscope
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Sports chiefs face losing battle to keep sport separate from politics
IOC president Kirsty Coventry's desire is that "politics does not take over on the field of play", but Ukraine and former executives from her organisation have told AFP that politics and sport remain…
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Birdwatching boost could slow aging, improve brain health
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Como Park Zoo euthanizes Skeeter the giraffe, a favorite of visitors and zookeepers
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'It Hasn't Made Any Difference': Gears of War PS5 Cancellation Fails to Boost Xbox
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CNN, MSNOW and Politico ask court to make Trump access order permanent
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Peter Schmeichel Questions Man Utd's Decision To Sell 'Goal Machine’
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University of Indianapolis offers free vaccinations to help keep Central Indiana healthy
The University of Indianapolis is proud to partner with the Indiana Immunization Coalition and the Central Indiana Area Health Care Education Center to offer a free vaccination clinic at the Schwitzer Student Center on Tuesday, Nov. 3 from 9 a.m. to 3 p.m. The clinic is open to all members of the public and will
Dodgers 40-man roster for 2026-27 offseason
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PODCAST: Keeping Native capital flowing through political change
Native CDFIs finance homes, support small businesses and create jobs. Keeping capital flowing into their communities also requires a voice in the policy decisions that shape federal funding and bank investment. In a new episode of Difference Makers 3.0, Native CDFI Network CEO Pete Upton and policy consultant Ian Record join host Brian Edwards to […]
PODCAST: Keeping Native capital flowing through political change
Native CDFIs finance homes, support small businesses and create jobs. Keeping capital flowing into their communities also requires a voice in the policy decisions that shape federal funding and bank investment. In a new episode of Difference Makers 3.0, Native CDFI Network CEO Pete Upton and policy consultant Ian Record join host Brian Edwards to […]
LeBron James and Whoop Partner as Health Tracker Keeps IPO in Sight
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The Israel debate reshaping Jewish American politics
“There are plenty of people who believe, as I do, that Israel has a right to protect itself,” says David to Lauren, both pictured below, over the dinner table. Subscribe “How does starving children protect Israel?” she replies. “I don’t think Israel is intentionally starving children.” “It’s a little bit absurd to be sitting here talking about all of these very specific things,” Lauren says, “as opposed to looking at the totality of him as a candidate, and the 90% of things that you agree with him on.” This is a snapshot from a conversation between a Jewish father and daughter in Michigan ahead of the crucial Senate race. Lauren supports the Democratic candidate, Abdul El-Sayed. Her father is undecided. That is mainly because of El-Sayed’s stance on Israel, one that mirrors a growing wing of the party that has become critical of the US-Israel relationship following the war in Gaza. You’re reading FourSight, a newsletter from Channel 4 News’ expert journalists explaining the complexities of the biggest global stories Could that alienate Jewish American voters who have a strong connection to Israel - and the majority of whom have voted Democratic? A shifting stance on Israel “An ally that takes your money to push you into wars you shouldn’t be fighting is not an ally,” El-Sayed recently told ABC News, referring to the Iran war and how some Americans believe that Israel pushed President Trump into the conflict. Foreign policy has become an economic issue that’s hitting Americans’ pockets, with the soaring cost of petrol and diesel. El-Sayed, pictured below, has opposed military aid for Israel and accused the nation of genocide in Gaza. That led to the pro-Israel lobby group, AIPAC, funding his opponent, Hayley Stevens, to the tune of $30m during the Democratic primary here. “I frequently criticise AIPAC because I think the way that they are pouring dollars into defeating Abdul and others around the country… is really corrosive to American democracy,” Brad Lander says at a canvassing event in Detroit. Lander, a Jewish Democratic congressional candidate in New York, is an ally of Mayor Zohran Mamdani and has come to campaign for El-Sayed. “Democrats and Americans don’t want to keep paying for Netanyahu’s wars,” he says. “They want a reset in the US relationship with Israel.” The 2026 election has clearly been a bruising one for AIPAC; the Wall Street Journal reported that, in an unpublished letter, the group described the cycle as one of the “most challenging environments in recent memory”. Share And significantly, after the midterms, the group will stop direct contributions to candidates through one of its political action committees. Voters’ concerns We followed a group of Jewish canvassers around one suburb in Detroit. They think that among the 130,000 Jewish voters in Michigan, between 20 and 30,000 are undecided. In a swing state where El-Sayed beat his primary rival by just 13,000, that could prove pivotal. We meet one voter, Jen Friedman, pictured below, who has a “Democrats for Rogers” sign, referring to the Republican candidate. The issue of Israel is very important to her because “having a safe haven is crucial”, she tells me. “What I see is one candidate, Mike Rogers, who is associating himself with people who are very proudly American,” says Jen. “Abdul, on the other hand, is associating with people who say they are anti-American.” Friedman raises two issues. Firstly, Hasan Piker, a left-wing streamer who has campaigned alongside El-Sayed and has been criticised for his comments on the US and Israel. [ ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) [ Why Hasan Piker thinks the US needs a socialist Trump ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) Anushka Asthana · Aug 19 [ Read full story ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) The other concern regards an attack on a Michigan synagogue back in March. The FBI said the man was inspired by Hezbollah and had lost relatives in an Israeli airstrike on Lebanon. El-Sayed condemned the antisemitic attack, but also said “hurt people hurt people”. That upset many here, with El-Sayed apologising numerous times for his choice of language. Jews for Abdul As we follow the canvassers, there are still plenty of lawn signs supporting El-Sayed. Elissa Driker, pictured below, runs out of her house wearing a “Jews for Abdul” t-shirt. “I feel like the values that Abdul has align with how I live my Judaism,” she tells me. She says “Abdul is not Hasan Piker, so I don’t conflate them”. I ask why Piker keeps coming up. “It gets weaponised. I don’t know if you watched the debate the other night, but talk about… weaponising fear and weaponising anxiety and all that Islamophobic dog-whistling that was coming towards Abdul.” I also talk to Elissa about how Americans more broadly appear to be questioning the US-Israel relationship and whether American Jews were ready to do that too. “A lot of American Jews are. My experience is absolutely the tide is turning.” For the first time, Gallup found this year that Americans now sympathise more with the Palestinians than the Israelis. In another poll of Jewish American voters, 65% said they were pro-Israel but also critical of Israeli government policies, 52% support cutting or eliminating aid to Israel. Father and daughter Back at the dinner table, I bring up those polls with David Fink. Why does he think Americans sympathise less with Israelis? [ ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) [ How support for Israel in US is declining ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) Kiran Moodley · May 4 [ Read full story ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) “Because the news media and the extremes of both parties are so willing to tell what I think is a false narrative.” Lauren chimes in: “Do you really think the actions of Israel have nothing to do with the shift in the sympathies?” “I think that’s very relevant,” he replies. “I just don’t think that people really have a full understanding.” Lauren again: “It sounds like you’re saying that the shift is due to how the atrocities are being described, as opposed to what the actual atrocities are.” “There have been some things that shouldn’t have happened,” David says. “I think the polling is being driven by politicians who are taking advantage of this issue.” Lauren then asks, “I’m curious what your response would be if my children were killed in an Israeli airstrike and someone said there have been some things that shouldn’t have happened?” A long pause from her father. “Any reference to my grandchildren has a very deep emotional impact on me. Well done,” he says. “I have an empathy for any civilian in war and I don’t mean to belittle those losses. The loss of any one life is a horrible thing. But it doesn’t make it a war crime and it doesn’t make it genocide.” Lauren and David cannot agree but tell me how proud they are of one another for sticking to their convictions and for agreeing to let me sit in on their conversation. I cannot thank them enough for their time, and hope their honesty informs and educates many people during such a fraught election. Abdul El-Sayed: The candidate testing the US - Israel relationship Thanks for reading our latest FourSight newsletter. Subscribe to receive free weekly newsletters from Channel 4 News. Subscribe Share Channel 4 News Leave a comment
Attainable Luxury at Scale: ZLINE Kitchen and Bath Keeps Operations Moving With Spectrum Business
Spectrum Business’s Dedicated Fiber Internet and Cisco-powered Managed Network Services give ZLINE Kitchen and Bath the reliable, enterprise-grade connectivity it needs for same-day fulfillment and cloud operations, without adding IT headcount.
Ria Health Brings 24/7 Peer Support to Virtual Alcohol Treatment Through Partnership with CHESS Health
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Many Texans must choose between healthcare and food
More than half of Texans worry about paying for food while keeping health insurance, writes columnist Chris Tomlinson.
Phillies' rotation is set, but they can't procrastinate on adding depth
Late-season injuries left the Phillies searching for innings in back-to-back years. Four possible additions could keep them from scrambling again.
Republicans are trying to make the Texas Senate race about “manliness”
Ken Paxton keeps accusing James Talarico of being “low-T.” Do voters care?
Just Got an iPhone Duo? Try These Features First
Apple's iPhone Duo launched on Friday, October 23 in markets around the world. Keep reading if you're the lucky owner of Apple's first foldable iPhone. Whether you're upgrading from an older iPhone or completely new to Apple, this guide will help you get the most out of your new device.
How Katie Lee channeled a chaotic coming of age into a business empire
Katie Lee is a success, by any metric. She has four bustling Katie’s restaurants to her name in St. Louis and a line of packaged goods—jarred sauces and pasta bakes and frozen pizzas—selling at retailers across the U.S. She also boasts 500 employees and a brand synonymous with Italian chic. Keep up with local business […]
A golden age of science is coming
It’s almost hard to remember, but just a few years ago, a lot of very smart people thought that science was in terminal decline. Respected researchers were writing papers with titles like “Are Ideas Getting Harder to Find?”, “Papers and patents are becoming less disruptive over time”, and “Slowed canonical progress in large fields of science”. In 1996, science writer John Horgan even published a book called The End Of Science: Facing The Limits Of Knowledge In The Twilight Of The Scientific Age. The fundamental idea was that the Universe only has so many insights to discover, and that we’ve picked the low-hanging fruit. It was the idea that Joseph-Louis Lagrange expressed when he said that “we cannot find more than once a system of the world to establish.” As the big ideas and the simple ideas get mined out, we’re forced to throw ever more brains at the mysteries of nature just to keep scientific progress going at a fraction of its old pace: It looked like science was hitting a wall. Then along came AI. It’s far too early to tell how much AI will eventually speed up the growth of total factor productivity. But already we can see signs of a speedup in science. Anthropic Founder Jack Clark assembled some of the hopeful data points in a recent lecture: [ Dror Poleg@drorpoleg "If you pick different parts of science, you see the same pattern show up: Progress is accelerating, and it has started to accelerate in the last two years." Jack Clark @jackclarkSF I’m speaking at the IMF in an hour about the singularity and why I believe it has begun and the choices we'll need to make. Watch live here: https://t.co/Hj9HzcXx5h 6:08 PM · Oct 18, 2026 · 21.2K Views 2 Replies · 10 Reposts · 123 Likes ](https://x.com/drorpoleg/status/2111882070376980529) Anthropic is accelerating its investment into drug discovery, and is already announcing some impressive preliminary results: [ BioTender@Junioryu136689 BREAKING: Anthropic unveils early results from six Claude-powered drug development collaborations. • 70% shorter CAR-T signaling domain • ~35,000 antibody designs • >10× tighter antibody binding • 89% less batch-record review time Still largely preclinical. Anthropic @AnthropicAI Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of 9:43 PM · Oct 27, 2026 · 11.2K Views 3 Replies · 24 Reposts · 205 Likes ](https://x.com/Junioryu136689/status/2115197821150495150) Claude also appears to be enabling rapid progress toward a treatment for food allergies. OpenAI, meanwhile, announced a possible breakthrough treatment for neurodegenerative disease. Meanwhile, Google Cloud Chief Scientist Pushmeet Kohli has a list of recent scientific advances that have been enabled by its new Gemini model, including breakthroughs in nuclear fusion reactor design, rare disease research, and quantum computing: [ Pushmeet Kohli@pushmeet Gemini 4 Argon is a step change in model performance. In recent weeks, it has had a transformative impact on the Science projects in our team at @GoogleDeepMind and our external collaborators, and helped make a number of remarkable advances across scientific disciplines. 🧵👇 4:47 PM · Oct 13, 2026 · 36.5K Views 8 Replies · 41 Reposts · 497 Likes ](https://x.com/pushmeet/status/2110049807385702623) But as cool as these stories sound, they’re just very minor, preliminary efforts. There are a number of reasons to think that AI is going to propel us into a golden age of scientific discovery. That age might not last forever — AI might still run into diminishing returns eventually. But the next few decades are probably going to be an absolutely amazing time for human science. The number of “effective researchers” is no longer limited The most important input into science is scientists themselves. Until this year, that meant human brains — talented, highly trained human brains. The number of trained human brains could be increased by sending more people to grad school, but only to a point — the smartest people tend to be sent into the hardest research fields first, and if you 10x the number of researchers, the average quality will go down. This constraint was already starting to bite, as Ekerdt and Wu argued in 2024: We argue that a substantial portion of the downward historical trend in U.S. research productivity is a composition effect resulting from self-selection in researcher ability and the dramatic expansion of the research sector…[W]e find that this composition effect has lowered average researcher ability by between 37% and 53%[.] And of course, low fertility was making the problem worse, because fewer children meant fewer people who were able to become future scientists. AI just blows up this constraint completely. If an AI agent can function as an autonomous researcher, there’s no constraint on the number of researchers in the world — you can just build more of them, by building more computer chips and data centers that enable the running of more AI agents. Whether or not massive hordes of agents can collaborate to solve individual problems much faster, increasing the number of agents allows them to tackle many different research questions in parallel. What’s more, these AI “researchers” can be trained incredibly quickly compared to human beings. A human scientist takes decades to train, and more years to reach the frontier of their research field by diligent reading and conversation. This is the “burden of knowledge”, and it’s commonly believed to be one reason ideas have been getting harder to find — by the time human scientists can get up to speed, they’re often so old that their ideas are no longer novel. AI just annihilates this constraint — it can assimilate the entire literature and reach the frontier of research extremely quickly, and it can also tell human scientists where the frontier lies without forcing them to discover that for themselves. It can also pivot to new research directions more easily than humans can. And there’s also a self-reinforcing economic cycle here. Because scientific advances enable higher GDP, they enable more resources to be invested into the creation of yet more electronic “scientists”. Now that doesn’t mean the amount of scientific research goes to infinity — there may still be some essential bottleneck task that human researchers are still needed to perform. There are some indications that AI’s progress on open-ended conceptual research tasks is slower than in other dimensions, and it may be that humans are still needed to provide some of this long-term conceptual thinking. I’d bet against this being true for much longer, but it might be true for a long time. Even in this most “pessimistic” case, though, the amount of effective capital that scientists can use to leverage their work just went up by a lot. AI eliminates the theory bottleneck Science proceeds by an iterative process of theory and experiment. The theory part of that cycle is typically short, but non-trivial — it took a couple of years after the blackbody radiation spectrum was observed for Max Planck to come up with the quantum hypothesis to explain it, and decades longer before quantum theory as we now know it was created. It took about a year for Watson and Crick to figure out the shape of DNA after the requisite data was gathered. AI will basically eliminate the theory bottleneck entirely — or at least shorten the turnaround time between experiment and theory by an order of magnitude. AI is an absolute beast at math. Recently, an OpenAI model solved some of the most important open problems in computer science, math, and theoretical physics, and no one even batted an eyebrow because that sort of triumph is becoming increasingly commonplace. One of those solutions was a proof that the Standard Model of Particle Physics could be mathematically well-defined — a problem that human theorists had so far been unable to tackle. Not all research relies equally on theory, but understanding novel experimental results almost always involves some important component of either mathematical or spatial reasoning. That part of the task has now been made much, much faster. And on top of that, science is now open to a greater number of humans who aren’t naturally good at theorizing. AI can read the whole literature Much of the work of human scientists involves reading and understanding endless amounts of papers and going to endless conferences and seminars. The purpose of that work is to understand the existing scientific literature. Understanding the literature allows scientists to do the following things: Come up with new ideas for hypotheses to test Avoid doing research that someone else has already done Synthesize approaches from different areas or fields AI can reduce this effort to almost zero. Consider this excerpt from OpenAI’s blog post about their new research into neurodegenerative disease: The team divided the analysis among thousands of AI agents powered by GPT‑Rosalind, an approach we call distributed biological reasoning. The agents examined a whole-brain CRISPR atlas…a dataset showing how gene disruptions affect different types of cells across the mouse brain. Each agent investigated a gene disruption, analyzed cellular responses, searched scientific literature, and proposed explanations for the results. Their reports were combined into a reasoning atlas linking genes, cellular effects, relevant publications, and possible biological mechanisms. The research team estimated that comparable human analysis and literature review, conducted one perturbation at a time, would take months to a year. The agents reproduced findings from human analyses while uncovering additional leads. Their assessments of novelty and scientific value also aligned with judgments from blinded human experts. These findings help prioritize further experiments needed to test the proposed biological mechanisms. Some of these insights point to new leads for understanding brain disease. [emphasis mine] This is one case in which parallel work by a large number of agents really does make a huge difference: [ Haider.@haider1 this is actually insane openai deployed thousands of GPT-Rosalind agents to analyze millions of mouse brain cells in 32 minutes, work that could take human researchers months to a year also the agents uncovered new leads for brain diseases like Alzheimer's and Parkinson's OpenAI @OpenAI GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in 2:41 PM · Oct 21, 2026 · 51.5K Views 26 Replies · 95 Reposts · 1.26K Likes ](https://x.com/haider1/status/2112917197903540516) Not only does instantaneous literature review vastly speed up the research process, but it allows AI to make novel conceptual leaps from combining approaches from wildly different fields of research. AI regularly does this in math research, combining results, approaches, and theorems from far-flung places that no human mathematician would have thought to combine. It can do it in science, too. Much of scientific innovation, historically, has been “recombinant” innovation — scientists applying insights from one field to another. With AI, essentially all research is now cross-disciplinary — AI can read not just the literature on a particular subject, but the literature on a million other subjects that might have produced useful techniques or insights for the problem at hand. Superscience So far, all of the factors I’ve listed are ways that AI can speed up science as it’s already done. I’ve basically described how AI can send gigantic hordes of superhumanly fast, superhumanly well-read, superhumanly mathematically gifted researchers to re-accelerate scientific discovery. But it’s also possible that AI will enable types of discovery — and ways of understanding the natural world — that no network of humans, no matter how large or how brilliant it was or how long it had to work, would ever be able to discover. In a post back in July, I wrote about how that might work: What if there are lots of…aspects of the Universe that [are] too complex to understand in terms of simple laws, but not so complex that they just dissolve into unknowable chaos? It’s possible that we can reliably control these complex phenomena with AI, even if we never reduce them to the kind of principles that we can teach a grad student in a textbook… Another way of saying this is that there may be laws of the universe that humans can’t understand but AI can. I call these “cloud laws” — causal regularities that can be exploited by technology, but which are too diffuse and complex for an individual human being to either intuit or communicate… Perhaps social sciences like economics, sociology, and political science obey similarly complex regularities, and AI can help us find them. Perhaps there are physical processes — plasma, or topological materials, or aerial turbulence, etc. — that obey cloud laws instead of chaos?… [H]uman collaboration is bottlenecked — it’s limited by our ability to intuit patterns at an individual level, and to communicate these patterns from one individual to another. AI, being a computer, just doesn’t have this sort of limitation; it can work with vast, diffuse patterns without having to break them into pieces or simplify them in order to compress them into the tiny pipelines of person-to-person explanation… If much of the Universe turns out to be ruled by cloud laws, we could be on the precipice of a scientific renaissance. In order to discover cloud laws, AI will need huge amounts of data about the natural world. AI figured out human speech by assimilating essentially all of the text humans have ever written. If it’s going to figure out hidden patterns in biology, neuroscience, materials science, etc., it’s going to need similarly massive amounts of data from physical instruments. That data will be far, far more than humans — individually or collectively — would be able to parse, label, characterize, or model. But AI was built to do this. If scientists simply build huge arrays of sensors to measure complex phenomena like the brain, the cell, the economy, etc., they may be able to feed this flood of data to AI directly and bypass human cognitive intermediation entirely. AI would then learn about the world directly, and it might learn things that humans never could. This “superscience”, if you want to call it that, would actually go beyond the kind of science humans have done heretofore. Many of the technologies it yielded would be beyond human comprehension — indistinguishable from magic. But to the AIs, they would make perfect scientific sense. In any case, it seems clear that the scientific slowdown that threatened human progress will now be delayed — at least for a while. Unless humans have somehow found most of the actual exploitable regularities in our Universe, we’re about to enter a new golden age of science. Subscribe Share
What’s on Paula Poundstone’s mind? Politics, comedy and a famous cat
Paula Poundstone's spontaneous wit will keep the crowd on its toes when the veteran stand-up comic comes to Columbus on Oct. 30.
Global Health & WASH
The US National Institutes of Health reopened its center and program-project machinery in force. NIGMS is funding Collaborative Program Grants for interdisciplinary teams, NIAID opened both its Immune Tolerance Network and a next-generation R&D call, the NCI runs its Carcinogen Hazard Assessment Monographs program, the National Library of Medicine is funding institutional training in biomedical AI and data science, and NIH reopened its Centers for AIDS Research. The tell: these pay for standing centers and multi-year consortia at institutions with an existing funded research base, not one-off projects, so the fit is an established US research institution, not a single investigator. Disease-specific foundations are again funding the researcher, not just the research. The Parkinson’s Foundation opened its Paul Oreffice Innovations in Care Award and the National Ataxia Foundation its Research Seed Money Grant. The tell, the same one we flagged last cycle, is a named early-career or seed award that builds a pipeline of scientists committed to one condition, so what wins is a researcher willing to specialize. The post-USAID global-health money is routing through a State Department program statement and multilateral innovation funds. The US Department of State’s Bureau of Global Health Security and Diplomacy opened its Advancing Global Health Annual Program Statement, Grand Challenges Canada opened Nexa Lighthouse for climate and health innovation in Asia and the Pacific at USD $250,000 to $2,000,000, and CEPI opened a rolling call on vaccine-manufacturing analytics. The tell: the largest health money this cycle sits in a standing program statement and in staged innovation vehicles, not in a single bilateral grant. Total Estimated Funding Pool: ~$35.4M across discrete grants. (Separately, large national-formula envelopes not counted in this total: U.S. Department of State, Bureau of Global Health Security and Diplomacy (GHSD).) This post is for paid subscribers. This helps support the time and effort it takes to curate and organize these opportunities. Subscribe To keep this accessible to everyone who needs it, we’re happy to offer pay what you can rates. You can find more details here. New opportunities: Paul Oreffice Innovations in Care Award, Parkinson’s Foundation. *New!* *Closing soon!* The Parkinson’s Foundation created the Paul Oreffice Innovations in Care Award to fund clinicians rethinking how people with Parkinson’s disease receive care. The Foundation is using pilot funding to move promising ideas into testable projects, backing work across four lanes: strengthening community clinician capability, redesigning care models, building patient-centered technologies, and defining the minimum clinical datasets that make better standards possible. It wants hypothesis-driven, clinically grounded projects that can generate evidence strong enough to attract further funding. By opening the door to clinicians at every career stage and strongly preferring projects that involve people with Parkinson’s in their design, the Foundation signals that it values practical, patient-shaped innovation over prestige. The strongest fits are US-licensed clinicians with a focus on Parkinson’s and an institutional home for applied care research. Geographies: united states. Who can apply: Clinicians of all career stages, from fellows to established faculty, who are licensed to care for patients in the United States and have a significant focus on Parkinson’s disease. Physicians must have completed a neurology residency (or justify how their training pathway benefits people with PD); allied health professionals must hold an advanced degree, typically a PhD. Fellows, those in mentored positions, and those within two years of starting an independent position require a mentor and a mentor support letter. The sponsoring institution’s grants office is the authorized recipient and funds are disbursed to the institution. Funding amount: Maximum of $200,000 over two years; up to three awards. Targeted Sectors / SDGs: Health; Innovation; Science & Technology. Deadline: November 1, 2026. Learn more and apply here. Design and Deliver the Next EIT Health Bootcamps, EIT Health. *New!* *Closing soon!* EIT Health is opening its call for consortia to design and deliver the next generation of its health start-up bootcamps, funding the curriculum, masterclasses, mentoring, and investor engagement that turn early health ventures into fundable companies. The organization is using these learning paths to strengthen Europe’s health innovation pipeline across digital health evidence, deep tech and AI commercialization, cross-border investment, and patient access. What EIT Health wants to back is not a single course but durable delivery capacity built by partners who span industry, education, and research. Requiring multi-country consortia and a revenue-sharing stake in the programs signals that EIT Health expects these bootcamps to outlast the grant. The strongest fits are established training providers, universities, and industry partners with proven reach into health entrepreneurs. Geographies: Europe. Who can apply: Consortia only (individuals cannot apply), comprising a minimum of two and a maximum of five independent legal entities. Partners must cover at least two sides of the Knowledge Triangle (industry, education, research), including at least one industry organisation, and at least two entities must be legally established in different Horizon Europe countries. Funding amount: Foundational Learning Path: up to EUR €112,000; Thematic Learning Paths: up to EUR €124,500 per path (up to four thematic projects); up to EUR €610,000 total EIT Health funding available under the call. Targeted Sectors / SDGs: Health; Innovation; Science & Technology; Economic Development & Livelihoods. Deadline: November 2, 2026. Learn more and apply here. Technology Transfer Offices & Entrepreneurship Support Call (Beyond the Lab: From Research to Venture), EIT Health. *New!* *Closing soon!* EIT Health is opening its Technology Transfer Offices and Entrepreneurship Support Call to fund consortia that will deliver the Beyond the Lab: From Research to Venture program for healthcare researchers. EIT Health is using the grant to build local capacity for turning laboratory science into incorporated start-ups, paying experienced technology transfer offices and entrepreneurship support providers to run masterclasses, structured mentoring, and a closing Pitch Day across two cohorts. It wants to back organizations that can walk researchers from discovery to company formation, not just teach theory. Requiring two transfer offices plus one venture-building provider signals that EIT Health values proven commercialization experience alongside academic reach. The strongest fits are European research-commercialization teams with a track record of moving health innovations toward investable ventures. Geographies: Europe. Who can apply: A consortium of two Technology Transfer Offices (representing higher education institutions or research organisations) and one Entrepreneurship Support Provider with demonstrated experience in venture building and start-up support. Applicants may apply for more than one learning path where they can demonstrate the required expertise and capacity for each. Funding amount: Up to EUR €77,000 in 2027 and up to EUR €77,000 in 2028 (up to EUR €154,000 total per consortium over two years). Targeted Sectors / SDGs: Health; Innovation; Science & Technology; Economic Development & Livelihoods. Deadline: November 2, 2026. Learn more and apply here. EIT Health RIS Country Representatives Call (2027-2028), EIT Health. *New!* *Closing soon!* EIT Health is seeking organizations to serve as Country Representatives across eleven Regional Innovation Scheme countries in central and eastern Europe for the 2027 to 2028 period. The money funds a national anchor in each country, an organization that maps the local health innovation ecosystem, connects startups and researchers to EIT Health programs, and builds the stakeholder relationships that let health ventures grow. EIT Health is backing local capacity rather than individual projects, which is why it accepts both single organizations and national consortia that span education, research, and industry. The requirement for co-financing signals that it wants representatives already embedded in their national systems. The strongest fits are established ecosystem builders with deep ties to health innovation stakeholders in one eligible country. Geographies: Croatia; Czech Republic; Estonia; Greece; Hungary; Latvia; Malta; Romania; Serbia; Slovenia; Turkey. Who can apply: Registered legal entities established in one of the eligible EIT RIS countries. Single organisations or national consortia may apply. Consortia must include at least two sides of the Knowledge Triangle (education, research and industry), and all consortium partners must be established in the same eligible country. Suitable applicants have demonstrated experience in healthcare innovation ecosystem development, innovation support and entrepreneurship, start-up acceleration, technology transfer, research and higher education, business support, and stakeholder engagement, with strong links to national innovation stakeholders. Funding amount: Up to EUR €182,000 per Country Representative (maximum funding per project); total call budget up to EUR €1,274,500; EIT Health funds up to 60% of total eligible project costs. Targeted Sectors / SDGs: Health; Innovation; Science & Technology; Economic Development & Livelihoods. Deadline: November 2, 2026. Learn more and apply here. Architects of Trust: Community-Driven Demand Creation for New TB Vaccines, Treatment Action Group (TAG). *New!* *Closing soon!* Treatment Action Group, with funding from Wellcome, is opening its Architects of Trust call to help communities prepare for the new tuberculosis vaccines now moving through late-stage trials. The money backs civil society and community-based organizations to raise awareness, surface local questions and concerns, and press policymakers toward equitable national rollout. By pairing each grantee with an advocacy mentor and running a strategy workshop alongside the Global TB Vaccine Forum, Treatment Action Group is building a durable advocacy bench rather than funding one-off outreach. The two-stage design, starting with a short expression of interest, signals that fit and community rootedness matter more than polished proposals. The strongest fits are locally trusted groups with real TB, immunization, or health advocacy experience and a committed project lead. Geographies: Brazil; Ethiopia; India; Indonesia; Kenya; Malawi; Mozambique; Nigeria; Peru; Philippines; South Africa; Tanzania; Vietnam; Zambia. Who can apply: National, subnational, or regional civil society organizations (CSOs) or community-based organizations based in one of the 14 eligible countries or in Eastern Europe/Central Asia regional networks, with experience in TB, immunization, or other health advocacy and in community engagement or policy advocacy; well integrated into stakeholder networks with membership or affiliation to other CSO or community networks; naming a dedicated project lead (’architect of trust’) who can attend the April 2027 Zaragoza forum in person; and holding (or committing to adopt) organizational policies on safeguarding (bullying, harassment, abuse, and harm), equity, diversity and inclusion, and legal compliance, research practice and governance. Funding amount: Grants of up to US$45,000 will be awarded to 8 CSO partners across 14 high-TB-burden countries plus regional networks in Eastern Europe and Central Asia; each grant funds 12 months of work. Targeted Sectors / SDGs: Health; Governance; Policy & Advocacy. Deadline: November 4, 2026. Learn more and apply here.
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