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Women's Kidney Health in Focus
Globally, one in 10 women lives with chronic kidney disease (CKD), which is closely intertwined with cardiovascular risk as part of the cardiovascular-kidney-metabolic syndrome.
Less sleep = less health; Led Zeppelin in the OR; dangers of people-pleasing; plus other stories with Vanderbilt Health sources
Prevention interviewed Beth Malow, MD, Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, for a story about two randomized trials published in Annals of Internal Medicinethat found decreasing sleep by just 1.5 hours each night was linked with increases in body weight, waist circumference, and sedentary time in adults with elevated cardiometabolic risk. Yahoo Healthalso picked up the story. WTVF News Channel 5 reporter Nikki Hauser interviewed Ashish Shah, MD, Professor and Chair of Cardiac Surgery, for a new video podcast series called “Why Nashville” where she interviews interesting people doing interesting work about why they came to Nashville and how it is going. Among the revelations: his go-to OR music includes Led Zeppelin and AC/DC. Everyday Health interviewed Aaron Brinen, PsyD, Assistant Professor of Psychiatry and Behavioral Sciences, for a story about the TikTok trend that encourages women to speak up about their concerns or they’ll develop an autoimmune disease. Overall, people suggest that suppressing feelings of anger, minimizing your own needs, or people-pleasing raises your risk. Telemundo Nashville broadcast a story on cyclosporiasis that quotes both William Schaffner, MD, professor of Preventive Medicine, and Juan C. Salazar, MD, MPH, chair of the Department of Pediatrics and system Pediatrician-in-Chief for Monroe Carell Jr. Children’s Hospital at Vanderbilt. Schaffner also spoke to WKRN News 2 about measles and The Cutabout shingles and long distance running. WREG (Memphis) and others picked up the measles story as well. CNN reporter Deidre McPhillips interviewed John Trahanas, MD, Assistant Professor of Cardiac Surgery, and Director of Thoracic Aortic Surgery, for a story about aortic dissection in last week’s death of U.S. Sen. Lindsey Graham. The Nashville Post published a story by freelance reporter Leah Hunter on robotic surgery, including a patient story and numerous quotes from Sekhar Padmanabhan, MD, Assistant Professor of Surgery in the Division of Surgical Oncology.
Caribbean Diet: Traditional Foods, Nutrition, and Cardiometabolic Health
Traditional and neo-traditional Caribbean food patterns emphasize locally produced plant foods, roots, legumes, fruits, and seafood, with observational evidence linking these patterns to more favorable cardiometabolic profiles. Nutrition transition, import dependence, changing food practices, and structural pressures are reshaping these diets, highlighting the potential value of culturally relevant and locally resilient food systems.
Scientists discover the nutrient that can supercharge cellular energy
Researchers discovered that leucine, a nutrient found in protein-rich foods, can supercharge mitochondria by protecting crucial energy-producing proteins inside cells. The breakthrough uncovers a powerful new link between diet and cellular energy — with possible implications for cancer and metabolic disease treatments.
Averly Health launches to transform cardiometabolic care in the UK
Averly Health, a joint venture between Reset Health and Pharmacy2U creates the first and only fully integrated national cardiometabolic care provider....
Once-Weekly Drug Demonstrates Promising Dual Benefits in Obesity and Metabolic Health
/PRNewswire/ -- New data highlight the potential benefits of survodutide, a once-weekly injectable therapy targeting both the glucagon and glucagon-like...
A Study Of 8,900+ Adults Found 2 Overlooked Clues To Heart Health
Two easy-to-miss numbers on your lab report may tell a bigger story about your heart and metabolic health.
Visceral fat loss associated with better long-term cardiometabolic, cognitive health | Harvard T.H. Chan School of Public Health
Irrespective of weight loss, maintaining a lower level of visceral fat—fat stored deep within the abdomen, wrapping around vital organs—may lead to better long-term cardiometabolic and cognitive health, according to two new Harvard Chan School studies.
Could a change in diet improve mental health? Metabolic psychiatry, explained.
Patients rave about how the keto diet has helped ease mental health symptoms. The data are limited, but encouraging.
Surprising obesity discovery rewrites decades of fat metabolism science
A key protein involved in fat metabolism has been found to do more than scientists once thought. Instead of just releasing fat, it helps maintain healthy fat tissue and balance in the body. When it’s missing or disrupted, the results can be surprisingly harmful. This finding reshapes how researchers think about obesity and metabolic disease.
Scientists say this common sweetener may be quietly rewiring your metabolism
Researchers say fructose is not just “empty calories” — it may actively push the body toward fat storage and metabolic disease. A new review found that fructose affects the body differently from glucose, disrupting normal energy regulation and promoting processes linked to obesity, insulin resistance, and cardiovascular problems.
“Zombie” Cells Reveal a Surprising New Driver of Chronic Inflammation
Dysfunctional mitochondria may drive age-related inflammation by helping switch on inflammatory genes, and blocking SLC25A1 reduced that activity. As people age, senescent cells accumulate in the body. These so-called “zombie” cells have stopped dividing but remain metabolically active, releasing inflammatory molecules that can contribute to persistent inflammation associated with frailty, cardiovascular disease, cancer, neurodegeneration, and
Fermented food microbiome: influence on oral and gut microbiota, and human health
Nature Reviews Microbiology - The bioactive compounds and microbial consortia contained in plant-based fermented foods support oral and gut microbiota, host immune function and metabolic...
Surprising study names which diet beats Mediterranean and low-fat diets for liver and metabolic health
Texas A&M AgriLife launches national equine metabolic health survey
A Texas A&M AgriLife survey of horse owners and industry professionals seeks to quantify the prevalence of equine endocrine disease
Here's the No. 1 breakfast mistake Americans make every morning, says oncologist and longevity expert
Ezekiel J. Emanuel has spent 35 years as an oncologist and expert on health policy. He shares his breakfast tips for better metabolic health, energy and longevity.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help.#placement_976606_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid976606 = window.pid976606 || rnd;var plc976606 = window.plc976606 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=976606;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid976606+';place='+(plc976606++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
Virtual SUD support platform Nosis launches to address lifestyle, diet needs
Nosis, a platform supporting substance use disorder (SUD) recovery, is launching from stealth in all 50 states. | The virtual startup leverages labs with health coaches and dietitians to address the biological and metabolic health needs of individuals in recovery.
HOMETOWN HEALTH: Study finds heart disease risk can be identified in children as young as 8
A UT Health Houston study identified proteins that can influence the risk of developing cardiovascular-kidney-metabolic diseases in adulthood.
Scientists discover hidden gateways that allow the brain to clear waste
The brain continuously produces metabolic waste that must be removed to maintain healthy function. Cerebrospinal fluid (CSF) plays a central role in this process by carrying away proteins such as amyloid-β, ...
Metabolic liver disease to hit 1.8bn by 2050, and other health stories
Top health news: Metabolic liver disease is on the rise; Global pandemic treaty deadline missed again; Hantavirus cases linked to cruise ship.
Pioneer of China NewCo model sued in US over trade secret misuse, double-dealing
A legal feud unfolding in New York is putting a spotlight on the work of a business development veteran who is credited for pioneering one of biopharma’s hottest dealmaking mechanism: the China “NewCo” model. In a lawsuit originally filed in New York state court and recently moved to federal court, China’s Lepu Medical Technology has alleged that biopharma business development consultant Su Zhang, who was hired to help shop its GLP-1 weight-loss candidates to Western partners, engaged in corporate double-dealing and trade secret leaks. According to the complaint, while acting as Lepu’s primary dealmaking liaison for a group of obesity and metabolic disease drug candidates, Zhang was secretly double-dipping as the acting chief business officer for a direct competitor, BrightGene Pharmaceutical. “She never adequately disclosed the role, never sought Lepu’s consent, and never proposed any safeguard,” Lepu alleged in its complaint, which was filed in July after Zhang’s consulting firm, CoDevCo, sought certain transaction-based success fees from its angry customer through an arbitration process in Singapore. Lepu, the parent company of Lepu Biopharma, has asked Zhang to pay back its $500,000 retainer and disgorge all benefits she received during the alleged breaches of fiduciary duty, plus other damages and relief. The company has also requested the court grant injunctions to protect Lepu’s trade secrets. The ill-fated partnership officially kicked off in December 2024, when Lepu tapped CoDevCo as its “exclusive business development mechanism” to identify collaborators for the company’s drug candidates. According to Lepu’s complaint, Zhang personally negotiated and signed the agreement as managing director for CoDevCo, which used her home address. Before the Lepu deal, Zhang made a name following a short stint as the global head of business development for Hengrui Pharmaceuticals. It was during her tenure that Hengrui signed a landmark deal granting exclusive rights for a portfolio of GLP-1 assets to Hercules, which was at that time newly established by a group of private equity and venture capital firms. In addition to the regular upfront and milestone payments, Hengrui also gained an equity stake in Hercules, which later became Kailera Therapeutics. The Hengrui-Hercules deal opened a new paradigm, where a Chinese biopharma company spins off certain early-stage assets to investors for further development through the creation of a new company abroad. The “NewCo” model quickly came into vogue as it allows Western investors to access high-potential assets originating from China at an early stage while giving the Chinese licensors an opportunity to reap long-term benefits through equity stakes in the new firms. The NewCo model proved its value when Kailera staged a record-breaking $625 million IPO on Nasdaq this April, merely two years into the Hengrui deal. Related Kailera CEO 'knew we were in a good spot' before obesity biotech's record-breaking $625M IPO On her LinkedIn page, Zhang described her work at Hengrui as “[b]uilding team and capability from the ground up,” forming NewCo and major pharma partnerships worth billions of dollars. Lepu clearly wanted that kind of track record to help boost its own cardiometabolic portfolio, which includes a range of assets for obesity, Type 2 diabetes, fatty liver disease and muscle preservation during weight loss treatment. “Lepu’s pipeline is very valuable, but only if Lepu could secure the right international partner to expand into the overseas market during the available commercial window,” the company argued in its complaint. The Chinese biotech said it had little knowledge of U.S. laws, customs or business practices in the business development field, and therefore “needed to rely entirely” on the expertise of Zhang and her team as the firm’s first engagement of a U.S.-based BD consultant. “Zhang’s dominating influence on the business development strategy is further evidenced by the fact that she personally controlled the business-development communications on behalf of Lepu with potential partners,” Lepu said in its complaint. After entering the deal, Zhang introduced Lepu to her four associates. According to Lepu’s version of events, all of them were allegedly employed at different time points to perform similar jobs at other Chinese companies that Lepu described as its competitors, while having access to Lepu’s confidential information. As such, Lepu described Zhang’s team as “a roster of individuals whose primary professional loyalty, by virtue of their concurrent full-time employment, ran to Lepu’s competitors.” As well as the specific examples set out in the case, a look at Lepu’s deals over the period suggests Zhang may have been involved in at least one transaction. During their partnership, Lepu, through its subsidiary Shanghai Minwei Biotechnology, also out-licensed its GLP-1/GIP/FGF21 agonist MWN105 to a NewCo called Sidera Bio in the fall of 2025. The deal included an upfront and near-term payment of $35 million, up to $1.01 billion in milestones, and a 9.99% stake in the Danish startup. It seems likely that Zhang facilitated the Minwei deal given that Lepu is on record as having used CoDevCo as its “exclusive business development mechanism.” The big shock for Lepu came in the form of a news article on June 25, 2025. The article, reporting on phase 2 data for BrightGene’s GLP-1/GIP receptor agonist BGM0504, identified Zhang as acting chief business officer of the Lepu rival. Blindsided by her association with BrightGene, Lepu confronted Zhang in July 2025. “Lepu was given assurances that there was nothing to be concerned about and told that Zhang would explain the matter to Lepu,” Lepu alleged in its complaint. “Zhang never did.” Lepu claimed that Zhang had the motive and opportunity to steer potential prospective partners toward BrightGene or other competitors. Later, in February 2026, one of Zhang’s associates joined BrightGene as the vice president for global business development, according to the complaint. Around the same time, Lepu sent written demand letters asking Zhang to account for her BrightGene role, identify what confidential data were shared with the rival firm, and provide any conflict-of-interest or firewall policies during the engagement. According to Lepu, neither CoDevCo nor Zhang answered the questions in their responses. Related Novo vs. KBP: How a $1.3B deal turned into a fraud accusation and an international legal fight In a motion to dismiss filed with the U.S. District Court in the Eastern District of New York on Sept. 4, Zhang’s legal team argued that Lepu’s agreement was signed with CoDevCo, and that an employee of the contractor does not owe fiduciary duties to the client. In its complaint, Lepu said: “That CoDevCo was the contracting entity does not insulate Zhang from personal liability for duties she personally undertook and personally breached.” Taking the argument one step further, the defending party argued that the consulting agreement “does not create a fiduciary relationship even between CoDevCo and Lepu; instead, it identifies CoDevCo as an independent contractor retained to market Lepu’s business to potential western partners.” Although CoDevCo was Lepu’s exclusive business-development contractor, there were no terms stipulating that the consulting firm should serve only Lepu, Zhang’s lawyer noted. As to Lepu’s claims that Zhang misappropriated trade secrets, the defendant argued that Lepu authorized the use of the information so Zhang’s team could perform their service per the agreement. In a rebuttal filed on Sept. 11, Lepu’s lawyer set out why they believe the Chinese biotech satisfied New York law’s misappropriation definition by alleging that the defendant used a trade secret “in breach of a duty or through improper means.” As an alternative to dismissing the suit, the defendant suggested the action should be stayed pending outcomes from the arbitration of a separate case in Singapore. While NewCo pioneer Zhang is defending her business arrangements, momentum behind the NewCo trend has continued unabated into 2026. Through August, Chinese biotech assets have spurred 15 NewCo deals this year, according to local trade publication PharmaDJ.
Parasites, often seen as villains, may help shape gut and metabolic health
Blastocystis has long been viewed mainly as a marker of parasitic infection. Emerging research suggests that its presence is not necessarily linked to disease, but may instead reflect greater microbial diversity and metabolic health in certain contexts.
Your Brain Cleans Itself While You Sleep – Scientists Just Discovered How Fast
AI reveals a striking two-speed cleanup system that helps the sleeping brain clear away harmful waste. During deep sleep, a waterlike fluid moves through and around the brain, helping remove metabolic waste associated with disorders including Alzheimer’s disease. This cleanup process is known as the glymphatic system. It was first described in 2012 by Maiken
The Next Big Health Crisis May Be Hiding In Your Liver
MASLD, a metabolic liver disease, is common and deadly
Higher ultra-processed food intake linked to multiple health risks
A higher ultra processed food (UPF) intake is linked to a heightened risk of several major chronic health issues, such as digestive diseases, high blood pressure, and metabolic syndrome/diabetes, as well as death, finds a pooled data analysis of the available evidence, published in the open access journal Family Medicine and Community Health.
Dogs may hold surprising clues to human longevity
Dogs and humans may have more in common when it comes to aging than scientists realized. Researchers with the Dog Aging Project found that patterns of small molecules in dogs’ blood were linked to longer or shorter lifespans in remarkably similar ways to those seen in people. These metabolic “fingerprints” could offer clues about the biological processes that drive aging, including metabolism, inflammation, and cellular stress.
New research reveals mental health toll of endometriosis and PMOS
Nearly 1 in 2 women with endometriosis or polyendocrine metabolic ovarian syndrome (PMOS) report depression, according to new national research, prompting calls for mental health support to be integrated ...
Keto diet cut liver fat by 67% in a clinical trial
A ketogenic diet outperformed Mediterranean and low-fat diets in several measures of metabolic health during a clinical trial involving people with obesity, prediabetes, and fatty liver disease. All three groups lost about 10% of their body weight, but keto reduced liver fat by 67%, compared with 45% for the other diets. About half of the keto group also no longer qualified as having prediabetes after four to five months.
As the GLP-1 Era Reshapes Weight Management, METAbiotics Launches with Science Designed to Support Long-Term Success
Today, Danone subsidiary The Akkermansia Company announced the U.S. launch of METAbiotics, a science-backed postbiotic brand developed from decades of pioneering research into Akkermansia muciniphila and designed to support sustained weight management and metabolic health.
Poor metabolic health can age the brain even in young people, finds new large-scale study
Two people of very different ages can have a similar level of biological aging in their brains. Such an occurrence is possible because aging and metabolic health follow two distinct pathways that influence ...
Scientists boost strawberry flavor and nutrition without changing growth
A surprising genetic twist shows that boosting a seemingly ordinary “housekeeping” gene can dramatically improve fruit quality without any trade-offs. By increasing the activity of a tRNA-related gene in strawberries, researchers unlocked richer color, stronger aroma, and higher levels of health-boosting compounds like anthocyanins and terpenoids. Even more striking, these enhancements came with zero impact on plant growth, fruit size, or sweetness—avoiding the usual downsides of metabolic tinkering.
Leucine does more than build muscle. It powers up your cells
The essential amino acid leucine can boost cellular energy production by protecting key proteins on mitochondria from being destroyed. The discovery reveals a new connection between nutrition and metabolism that could eventually lead to new approaches for metabolic disorders and cancer.
Traditional Inuit Diet: Foods, Nutrition, and Health Effects
Traditional Inuit diets combine nutrient-dense marine and terrestrial country foods that remain important sources of protein, vitamin D, vitamin B12, iron, and other essential nutrients. The transition toward market foods is occurring alongside changes in cardiometabolic health, micronutrient intake, and gut microbiome patterns, while food insecurity, socioeconomic conditions, physical activity, colonial processes, and environmental change complicate the relationship between diet and health.
Beyond ‘dad bod’: What an expanding middle may mean for metabolic health
Columnist Carrie Dennett shares how men can start making more meaningful changes to reduce excess visceral fat (fat stored deep within the abdominal cavity).
Role of Physical Activity in Obesity Treatment and Cardiometabolic Health
Obesity affects 42% of adults in the United States and is strongly associated with major cardiovascular disease risk factors, including high blood pressure, abnormal cholesterol levels, and insulin resistance, making effective obesity treatment a critical public health priority.
Scientists discover a hidden problem with this popular sugar substitute
Sorbitol, a sugar alcohol commonly used in sugar-free candy, gum, and other low-calorie foods, may not be as harmless as it seems. Researchers at Washington University in St. Louis found that the body can convert sorbitol into a form of fructose in the liver, potentially triggering some of the same harmful metabolic effects linked to fructose.
Who’s selling longevity? Biohackers are buying.
Several companies are currently positioning themselves at the crossroads of metabolic health and longevity
Cannabis compounds may boost metabolic health while supporting weight loss
Researchers identify potential mechanism linked to reduced type 2 diabetes risk
New UMSOM Research Shows Promising Results for Health Care Professionals Using Ketogenic Diet Therapy to Treat Mental Illness
Specialized high-fat, low carbohydrate diets, known as ketogenic metabolic therapy, are showing promising therapeutic benefits for certain mental illnesses in emerging research. Now, a new study from researchers at the University of Maryland School of Medicine’s Maryland Psychiatric Research Center (MPRC) shows that an immersive training program can improve health care provider confidence in using a ketogenic dietary treatment plan for their patients.
A 30-year follow-up: Yale researchers reconnect with child participants in metabolic health study
For more than three decades, Yale researchers have partnered with young people across the state to better understand the biological factors underlying metabolic health.
An Avocado a Day May Keep Diabetes, Hypertension, and Obesity at Bay
Research suggests that eating more avocado may help reduce your risk of diabetes, lower blood pressure, and reduce your risk for obesity and other cardiometabolic risk factors.
Advancing Women’s Heart Health Through Prevention and Rapid Diagnosis
Early intervention based on accurate diagnosis of both metabolic risk factors and acute cardiac events could help make the difference between life and death for women.
Ebola, chemical plants and health, hantavirus, common colds, heat and more
As they say, bugs have ears. Public health has had a relentless May. Chemical plant (near) explosions, Ebola, hantavirus, and that's before you even get to the usual suspects: common colds, heat, and ticks. Here’s an attempt to keep you up to speed and, more importantly, what it means for you and your community. But first, an announcement: World Cup The World Cup starts in 15 days (not like anyone is counting down), and we are hanging TVs in the Health Security Operations Center. It’s going to be a gorgeous, chaotic celebration of basically every culture on earth. And it’s going to take a team effort—from communities to individuals, from public health to health care—to keep people healthy. That’s where you come in. If you’re going to the games or live within 30 miles of a stadium, we would love to hear from you. Sign up for a weekly survey here. Thanks to the more than 1,280 people who have already signed up…you will be hearing from us soon!! Global disease “weather report” Hantavirus: Two more cases The global count of cruise ship passengers with hantavirus has now increased to 13 cases (11 confirmed), with three deaths. The two new cases are overseas and among people who were already quarantining: A crew member in the Netherlands. A Spanish national passenger who was quarantining at home tested positive through daily monitoring. They are now in a biocontainment unit. In the U.S., everyone remains negative. There may be more cases, given that the incubation period of hantavirus (the time from exposure to infection) is 45 days. But this week, we will reach a major milestone: the median incubation window is 18 days, and that will pass on May 29. What this means for you: Your risk from this cruise ship outbreak remains essentially nil at this point. Ebola rages on in Central Africa Big thanks to Dr. Craig Spencer, a humanitarian physician who has treated and survived Ebola, for jumping in to provide the YLE community with an update. Craig, take it from here… The combined confirmed and suspected Ebola cases in DRC are now more than 1,000. All signs are pointing to a very long and catastrophic outbreak in Central Africa: This is a vast undercount. We know this because the test positivity rate is hovering around 50%, only 20% of contacts are being traced (and in some areas, no contacts at all), and more cases keep popping up with no known connection. This all points to widespread and undetected community transmission. This is in only a week of detection. Compared to previous outbreaks, the growth is very fast, as the huge West Africa outbreak in 2016 was first detected at 49 cases and rose to 208 cases a month later. It took four months for that outbreak to reach the size of the current one in the DR Congo. The cases are spread out across 16 health zones. There are now multiple epicenters, making containment very difficult. Next door in Uganda, the case count is seven. While this number is low compared to DRC, a concerning development is that two health care workers recently tested positive with uncertain exposure histories. If they weren’t treating known Ebola cases, this means it’s spreading undetected in Uganda as well. On the ground, backlash, including the burning of health centers, has emerged, a pattern seen in nearly every outbreak and rooted in deep community distrust. It often stems from outside actors working in communities without fully understanding or addressing local priorities. Affected populations may recognize the severity of Ebola while still holding other concerns as more pressing, such as where their loved ones are buried. Community trust is essential to an effective response, but difficult to build during an active emergency. It is best established long before a crisis begins. U.S. priorities are made clear, and may backfire. The U.S. Administration has shown that its first priority is keeping Ebola out, with helping end the outbreak in the DRC a secondary concern. That's meant travel restrictions broader than anything we've imposed before — covering travelers from across the region, and reportedly some green card holders and permanent residents as well. For example, just these past two days, news broke that high-risk American travelers will be subject to a mandatory quarantine in Kenya before they are allowed to return. If an American is infected, the U.S. government plans to send them to a hospital it is standing up from scratch in Kenya. (Currently, Americans who were in the area are allowed to return but are diverted to three airports—Houston, Atlanta, and DC—for further screening.) Past administrations have used travel notices and stepped-up screening; this goes much further. At first blush, these strict precautions may sound prudent. But this approach could backfire in three ways: Restrictions this blunt give people every reason to hide where they’ve been and whom they’ve been near — making the people we most need to find harder to track, not easier. They also breed a false sense that this is someone else’s problem. But diseases are humbling. They find the small cracks in even the most impenetrable-seeming defenses. Lives lost. There is no treatment for this Ebola strain, which means survival depends heavily on the quality of the health system. We have that system in the States, but we are choosing not to use it for infected Americans. This is unbelievable and infuriating. (See a deeper dive from me here.) The only real way to lower the risk to Americans — and everyone else — is to end the outbreak in the DRC and across the region. What this means for you: If you have travel plans to this region, it’s time to cancel them. This is a high-risk situation in Central Africa, and CDC released a Level 4 Travel Advisory. There is also great uncertainty if and when the Administration will let you back in. To the general public in the U.S., your risk remains very, very low right now. U.S. disease “weather report” Ticks: past peak season? Good news, especially for people in the Northeast and Midwest: tick numbers continue to decline. Though we are at the peak of the season, this unusually early year is trending favorably. Heat-related illnesses in the North Heat risk is certainly not blanketing the entire country yet, but this week it will be moderate in the Midwest and the Southeast. What this means for you: Be sure to check the CDC HeatRisk tool. A red day isn’t the best day for that soccer game for a kid with asthma, and a stretch of orange days is a great time to check on your elderly neighbor. Common colds surging As far as respiratory viruses go, the only thing really going around right now is the common cold. It is higher this year than last year, but should peak very soon before returning this fall. Spotlight: Chemical plants Over the weekend, YLE California covered the serious situation that unfolded around a chemical plant in Orange County, California. Thankfully, the worst-case scenario (a chemical explosion) was mitigated, but only through luck. The health implications in a densely populated area could have been catastrophic. As the situation was winding down, another chemical explosion struck Washington State. This one was fatal. Health officials say the risk to surrounding residents from chemicals in the air and ground remains low, though the community deserves far greater clarity. Clean air and clean water consistently rank as Americans’ top public health concerns — yet when chemical disasters strike, communities are too often met with reassurances rather than transparency and accountability. Residents near the 2023 East Palestine, Ohio train derailment, for example, are still waiting to understand the long-term impact on their health, with few clear answers. What this means for you: Many are wondering if facilities processing potentially dangerous materials are in their neighborhoods. This interactive map allows you to enter your ZIP code and see all facilities monitored by the EPA, including any violations. Good news Ebola vaccines and treatment for the Bundibugyo species are in development. Two vaccine platforms are being explored, at least one of which may be deployable in as little as 2 months. One vaccine is being developed by Oxford, and the other uses the same biotechnology as the FDA-approved Zaire species of Ebola. (It may provide cross-protection, but it’s unclear at this point.) On the treatment side, two promising monoclonal antibody cocktails are likely to be deployed, though doses are limited and logistical hurdles remain significant challenges. Anni over at The Biotech Tea had a great explainer about the Ebola vaccine gap, if you want to read more. [ The Biotech Tea The Ebola vaccine gap, reading vessel damage, & the Makary exit 🗝️ Paid subscribers get the Biotech Term of the Week at $30/year (~$2.50/month). I try to keep it intentionally accessible, but if cost is ever a barrier, send me a message. A few people asked about expensing your subscription, so I put together a short email template… Read more 6 days ago · 10 likes · Annicka Evans, PhD ](https://www.thebiotechtea.com/p/the-ebola-vaccine-gap-reading-vessel?utm_source=substack&utm_campaign=post_embed&utm_medium=web) Polycystic ovary syndrome (PCOS) has been officially renamed polyendocrine metabolic ovarian syndrome (PMOS), following more than a decade of debate and input from roughly 22,000 clinicians, researchers, and patients worldwide. This is good because the old name was medically misleading, leading to patients without visible cysts being dismissed or overlooked entirely. The WHO estimates that 70% of people with the condition remain undiagnosed. A more accurate name should improve recognition, reduce stigma, and ultimately help the millions of people living with this condition get diagnosed and treated sooner. Poll Loading... Bottom line Public health situations are everywhere right now. Staying healthy takes public health professionals and systems working tirelessly behind the scenes and each of us showing up for our neighbors and communities. Love, YLE Big thanks to Ed Nirenberg for staying on top of the Ebola vaccines, Hannah Totte for all the figures, Dr. Craig Spencer for the Ebola insight, and Dr. Matt Willis for covering the chemical situation in CA. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “Translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Boehringer Ingelheim and WHO Foundation launch global collaboration to close the gap in obesity and metabolic health
/PRNewswire/ -- Boehringer Ingelheim and the WHO Foundation today announced a three-year collaboration to accelerate progress on obesity and its related...
A gut microbial health index as a composite biomarker for evaluating overall health
Each person has a unique gut microbial population, with variation shaped by diet, lifestyle and disease. We are seeing a rapid rise in metabolic disorders, obesity and inflammatory diseases that cannot ...
Why a shorter eating window may not mean better metabolic health
In a nationally representative cross-sectional study of 16,973 Korean adults, researchers identified three distinct eating patterns based on the timing and distribution of daily energy intake. Eating later within a shorter daily window was associated with higher odds of metabolic syndrome, elevated blood pressure, triglycerides, and fasting glucose, while frequent grazing showed a mixed metabolic profile.
Losing the Same Weight Didn’t Produce the Same Health Benefits
Among several diets tested in a clinical trial, a ketogenic diet produced the greatest improvements in liver and metabolic health. Losing the same amount of weight does not necessarily produce the same metabolic benefits. In a randomized clinical trial, three very different diets helped adults with obesity lose about 10% of their starting weight, but
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.#placement_1126603_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid1126603 = window.pid1126603 || rnd;var plc1126603 = window.plc1126603 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=1126603;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid1126603+';place='+(plc1126603++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help. Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
What science says about ultraprocessed foods and the aging brain
The colorings, additives and preservatives added to food products, as well as food processing techniques, are a source of concern in 2026 because they are ubiquitous worldwide, yet their effects on metabolic ...
A New Study Explores Whether Exercise Can Really Cancel Out the Health Risks of Your Desk Job
Scientists debate whether it’s possible to fully reverse the metabolic effects of a sedentary life.
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping its competition with various other consumer wearable sensors. These “readiness scores” as a composite of multiple metrics, with heart rate variability (HRV) being front and center for most. The majority of Americans are now using wearable sensors, which equates to well over 100 million adults. HRV and Readiness scores are increasingly being marketed as a measurement of autonomic nervous system health, a digital marker for future disease, a clock for biological age, and a holistic metric to promote healthspan and even longevity. (Apple also introduced a new longevity tab and “Health Age”.) None of this has been proven. In this edition of Ground Truths I am going to review what we know about heart rate variability and readiness scores. Heart Rate Variability HRV is the variation in normal heart cycle timing. The variability of the heart rate, the barely perceptible millisecond changes in time between consecutive heart beats (see R-R intervals in the Figure below, left panel), is due to interplay between the sympathetic and parasympathetic (vagal nerve) inputs. Distinct from heart rate, individuals with the same heart rate can have very different HRVs. It is a rough reflection of the autonomic nervous system (ANS) activity, inadequate to say whether a person’s ANS function is abnormal. For more than three decades, heart rate variability (HRV) has been measured and several studies have found an association of low HRV and clinical outcomes, particularly a link with higher all-cause and cardiovascular mortality. There have also been less well established links of low HRV to risk of early cognitive impairment, dementia, mental illness, Type 2 diabetes and substance abuse. An important reminder is that HRV is a surrogate marker without any established cause-and-effect relationship. If you increase your HRV, that doesn’t mean it will improve health outcomes. In fact, there is no hard evidence for that. All that work linking to health outcomes was done with electrocardiogram (ECG) derived HRV. Now, in the era of consumer wearables, this is getting assessed differently, by optical pulse (yes, the lights you see) plethysmography (PPG) or what is called pulse rate variability (PRV). They are not the same, as shown below (right panel) and only concordant when the delay between the ECG and pulse is kept constant, which basically means at rest. I should mention there’s also what I will call MPV, a mattress mechanical movement sensor, a derived heart rate variability, that companies like Eight Sleep use, even further away from directly measuring HRV. HRV has not one uniform measurement but many different types of quantification, such as RMSSD, the magnitude of difference between successive R-R intervals of normal sinus beats (N-N) or SDNN, the standard deviation of NN intervals, both in milliseconds. SDNN is one of the so-called frequency domain HRVs (others are LF, HF, LF/HF). Different wearable sensors use different metics; Apple has relied on SDNN and nearly all of the others use RMSSD, which is generally considered the more accurate metric. There’s also the different length of time measured, such as for a matter of minutes, all day, or an overnight’s sleep. Short measurements are especially problematic since they don’t capture enough of respiratory modulation and other factors that influence HRV. Share Ground Truths How well does HRV correlate with PRV? There are very limited studies, especially independently done. One that is commonly cited was conducted by Air Force researchers in only 13 healthy adults assessing Oura ring 3 and 4, Whoop 4.0, and Garmin Fenix 6 and showed a correlation coefficient of 0.88 to 0.97 and a mean absolute percentage error from 6 to 10%. The correlation is not a perfect 1.0, but there’s at least a fairly high level of correlation. HRV is supposed to increase during the night due to takeover of the parasympathetic nervous system, and higher during deep sleep. A recent example of my 1 week, all day “HRV,” and one during sleep is shown below. As you can see, the N of 1 data are inconsistent for the same days from different sensors (Oura, AppleWatch, Fitbit Air, and Eight Sleep) by patterns, absolute numbers, and comparison with prior days and weeks. The largest study in over 8 million Fitbit users (the old version, not Google Fitbit Air, introduced in May 2026) gives you a sense of the effect of age, sex, and the 2 different main HRV (here PRV) metrics, with RMSSD on the left and SDRR (=SDNN) on the right below. That study, from data collected in 2018, is a major outlier, since all the more recent ones are tiny with respect to sample size. Many of the companies have not had independent evaluation of their HRV, such as Eight Sleep, but have published a low standard error on their website. There are some other published studies on the correlation between HRV and PRV, but they are all small and only in healthy adults. A scoping review emphasized the lack of study in underrepresented individuals, including the aged, people of color (which affects the PPG signal), and individuals who are underweight or obese. Add the typical adult age 60 plus with one or more chronic diseases. For example, one study in over 900 adults found poor correlation of HRV and PRV, non-uniformly underestimated across many chronic diseases (cardiovascular, endocrine, neurological, respiratory, and others), concluding PRV is “an invalid surrogate for HRV.” A recent systematic review of 43 studies comparing HRV and PRV found reasonable pooled absolute standardized error (HRV as gold standard) but only 10 of the studies provided quantitative synthesis in ideal conditions. Their main conclusion was similarly cautious: “PPG-derived HRV [PRV] should not be regarded as universally interchangeable with ECG-derived HRV across all devices, populations, and recording contexts.” Factors Affecting HRV and PRV That gets me to the long list of factors that affect HRV (and PRV) besides the device, the type of measurement (RMSSD, SDNN or others), the person’s signal, the sensor site, the duration of data capture, if weighting by sleep stage is used, how artifact is processed and corrected. And this list is not complete!: Oura puts out data from their community of users (who input data) on what affects their overnight HRV. The factors currently provided are: no alcohol (increase 8%), melatonin (increase 2%, float tank (increase 2%), wine (decrease 4%), and party (decrease 14%) in overnight HRV. Must be some big parties! Subscribe What is a PRV measurement good for? It has been falsely characterized as an index of “autonomic balance” and a specific indicator of stress. A 2018 review of the studies available for HRV and its relationship to stress, not using any of the current wearables, found that stress can lower HRV. But so can many other factors. The non-specificity of the signal, indexed to the table above, is striking. Evidence from a UK Biobank study of over 46,000 participants with actual HRV looked at genetically predicted HRV, a genetic risk score, that failed to show the expected HRV-mortality link, indicating that _HRV is likely not causa_l, but rather a reflection of person’s physiologic state. A review of consumer wearable HRV data from 5 longitudinal studies showed that nighttime PRV was not associated with perceived stress, and surprisingly higher HRV, in the largest cohort (N=717 participants), was correlated with higher stress. An Oura ring cohort of 525 first-year college students found a link between overnight PRV and perceived stress, but that was also seen with resting heart rate, sleep, and respiratory rate. Several very small studies have examined the relationship of HRV and athletic injuries or guiding training with mixed, and predominantly negative results. HRV biofeedback training with paced breathing had no significant effect on reducing stress or raising HRV, as demonstrated with sham controlled trials. When HRV for multiple days showed a decline in conjunction with body temperature, the Oura ring published data for prediction of Covid. The WHOOP company sponsored an observational study, published in 2026, of 30,000 users for 72 weeks, without a control group, that reported reduced alcohol intake (5.8 % points) by self-report. That doesn’t tell us much, and particularly about the merits of HRV for behavioral change. If you use the same device and conditions as longitudinal trends for multiple (at least 2-3) weeks that may be the one way to get something useful from the measurements. Data for overnight sleep with minimal motion and using RMSSD is the best proxy for real HRV. The reason to look at trends rather than any given night is that it more likely represents something, even though you won’t know with certainty what the “it” is. Keep in mind there are no data, no peer-reviewed evidence, to show that HRV fluctuation in-person has any correlation with health outcomes. Share Readiness Scores These are proprietary scores that integrate different metrics for each of the wearables: no algorithms have been disclosed. They are unvalidated against health outcomes. In a review of 14 composite health scores of readiness and recovery, HRV contributed 86% to the scores, followed by reading heart rate (79%), physical activity and sleep duration (both at 71%). That review noted the substantial variability in measurement protools and lack of standardization. Sleep staging is notoriously inconsistent and inaccurate by these sensors, which adds further to the HRV uncertainties for what the scores, which use sleep stage data, mean. Only resting heart rate has been shown consistently across devices to be extremely accurate. I’ve made a Table to summarize what we know about which metrics are included, the scores, any peer-reviewed studies that compared the readiness score with health outcomes, and the corresponding (if any, NA-not available) citation. You will note that some companies do not use the term “readiness," such as WHOOP for recovery, and Garmin, which has 2 different scores, one of which is Body Battery. Eight Sleep uses the term “Fitness Score.” They all include HRV; Apple includes a new metric they call “Recovery HRV” which among other components uses 7-days of sleep, but it is unclear what this means or how it is differentiated from other scores (there are clearly no data for outcomes). We have no knowledge of how the different components are weighted or whether any of these scores are better than resting heart rate, HRV alone, physical activity, or any other single metric. Since none of these are standardized, they are not interchangeable, so if you get a 90 for Oura that has no relationship to a 90 on a Google Fitbit Air. Notably, the company can update its algorithm for readiness score at any point without notification to device users. Without any useful evidence of actionability for these scores or established relationship with health outcomes, it is hard to make a case for their value. At the Apple recent announcement they showed their Readiness score (0-10) on the watch (Figure below) but there are no published data on this score, not even on their website. It’s available only on their new Watch Series 12 or Ultra 4 [of course, ;-)]. That exemplifies the problems with these scores, lack of data and evidence for being meaningful to promote health. Perhaps the best study (which isn’t saying much) is the WHOOP Recovery for golfer performance, because it did correlate with an objective outcome, even though there was no control group and the authors were all from the company. Among the 389 pro golfers, an absolute 10-per cent point increase in Recovery score was associated with about 0.5 fewer strokes per round. But that’s hardly a health outcome! WHOOP is also conducting a study in over 2,700 runners to see if their recovery score will be linked to less injuries and improved performance, but that is not yet published and has no control group or randomization. Putting This in Context For two decades I’ve been enthusiastic about the potential for digital health and particularly wearable biosensors. Over the years, we’ve seen some great progress for their ability to promote physical activity and accurately detect atrial fibrillation (the first FDA cleared deep learning AI for consumers). That work was the subject of rigorous research. But there are holes in the data and evidence for other metrics. One notable one is the “VO2 max” story that I wrote about earlier this year. At that time many subscribers asked me to cover heart rate variability, which I finally got to here. When I dived into the research and publication for HRV and readiness scores, I expected to find at least some that were of high quality and demonstrated their utility by linkage to health outcomes. To my surprise, I found none. The wearable sensor measurements for HRV (PRV) are, for the most part, accurate, but that validation work has only been done in small studies of healthy adults and does not take into account the long list of factors, from the device, software side, and the user side, that affect HRV measurements. Moreover, this metric chiefly relies on optical sensing and, as we have learned for heart rate PPG sensing, may be less accurate in people of color. Keep in mind that all of the health outcome association evidence comes from ECG-derived HRV; none are from wearable sensor data. I will repeat the key point: there's no peer-reviewed evidence to show that in-person HRV fluctuation—or efforts to raise your HRV— has any correlation with health outcomes. For those of you who look at your HRV on awakening, or even 2+ week trends of it being low, I hope this context helps to relieve any anxiety. Yes, low HRV (not PRV) has been shown to increase risk of some diseases as summarized above. But efforts to raise your HRV—a surrogate metric— has not been established for improving any health outcomes. HRV does not have any evidence of causality (the genetic evidence actually goes against this possibility). In this summary, I have not included data for other wearable sensors such as Polar, Samsung, Withings, Suunto, Amazfit, Coros, Ultrahuman, or additional mattress sensors. These are beyond my first-hand experience, and as far as I know from my in-depth review none have any peer-reviewed published data that differ from the 6 sensors I’ve reviewed here. From the points I’ve gone over above, we’re not ready for readiness scores. Besides being proprietary, they are predominantly based on metrics that have their own issues. It’s compounding the problem, like building a house without a solid foundation that has never undergone a rigorous inspection, and then selling it. Like I mentioned for PRV, you can look at trends over weeks rather than any single day, to get a handle, but even that may not be helpful. There’s simply no evidence that these scores meaningfully relate to health outcomes. I’d emphasize they might, but that requires doing prospective or randomized studies to prove it. None exist. There’s great promise for HRV/PRV utility_. For example**,**_ Prof Maiken Nedergaard, who discovered the brain glymphatics that are essential in eliminating metabolic waste products from the brain during sleep, has posited that HRV could be a non-invasive marker for neuromodulator oscillations, brain-body regulatory circuits, and brain clearance. That would be extremely useful, but like everything else on HRV and readiness scores it requires solid research and validation. The lay media isn’t helping much to get the story straight. Earlier this year The Economist published a piece entitled “The most useful indicator of your overall health” which ordained HRV as an “accumulated stress score.” That’s akin to the false assertion about VO2max: “V02 max is the singular most powerful marker for longevity.” As I’ve summarized here, that is not established. The fact is that so many things can lower HRV, including physical exercise (especially an intense workout), reduced sleep quality, stress, the list above, no less the device, signal, and software. Whatever fluctuations observed have not been correlated with any health outcome. Sadly, “datamaxxers” are widely using HRV and readiness scores that have never been validated to mean anything. We already know that for some people using the sensors for sleep metrics, it can induce “orthosomnia,” an obsession to get high sleep quality, with associated high levels of anxiety. In an experiment done by a company to promote sleep quality for its employees, “For those employees who did use the trackers, many reported feeling perfectly rested until their tracker told them they had had a terrible night. Others were told that they had slept like a baby when they had actually been lying awake worrying about the quality of their sleep. “ The same problem can result from preoccupation with HRV or readiness scores, with anxiety that would lead to further reduction in both. It you are using a wearable like >100 million American adults, it’s OK to look at these data, but contextualized with the major caveats reviewed here. If you are one to require evidence that HRV or readiness scores are linked to health outcomes, you may not even want to look. The companies make it hard to turn them off! Let me end with the companies that make and sell wearables. Apple’s doubling down on HRV (24-fold more reporting and heart rate very 5 seconds) and introduction of a Readiness score tells us that consumers have bought into these metrics and they are joining the club. However, all of this is occurring with a backdrop of tens millions of users, claims about the data that are not backed up by adequate evidence, marketing way out in front of whatever limited data exists, and not being transparent about their readiness score algorithms. The companies can well afford to do the research that is needed to connect these metrics with health outcomes show, once and for all, that increasing HRV or using readiness scores promotes our health. If they believed and invested in the products they are selling, we’d not be in this position of not knowing. That’s essentially where we are with HRV and readiness scores. Perhaps someday this will change and we’ll have good reason to embrace them. NB: I wrote this post. No AI. I have no conflicts of interest with any of its content. Loading... Ground Truths has 215,000 subscribers from every US state and 214 countries. There are over 300,000 followers of Ground Truths so more than 90,000 folks who can easily convert to be free subscribers. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. If you’re not a subscriber, please join! If you found this interesting PLEASE share it! Share Ground Truths The proceeds from all voluntary paid subscriptions go to support our summer internship program. It enabled us to accept and support a record number of 62 summer interns that joined us in 2026! These are high school, college and medical students selected from thousands of applicants. We couldn’t do this expanded program without the funds coming in through Ground Truths. Thank you!
P.C.O.S. Has Been Renamed P.M.O.S. Doctors Hope It Will Improve Care for Millions.
The condition has been renamed polyendocrine metabolic ovarian syndrome, or P.M.O.S., to better reflect its wide-ranging health effects.
September brings new name for PCOS
Polycystic ovary syndrome has been renamed polyendocrine metabolic ovarian syndrome to emphasize metabolic health and improve diagnosis and treatment.
ACC-AHA release first cardiovascular-kidney-metabolic syndrome guideline
Science shows the deep relationship between cardiac, kidney and metabolism issues that may impact up to 90% of the U.S. population.
Why renaming this common hormonal disorder is a huge deal
You probably know someone who has a condition that, until last week, was known as PCOS, or polycystic ovary syndrome. It affects one in eight reproductive-aged women. But despite it being such a common disorder, patients are often misdiagnosed and have delayed treatment. Now, medical professionals are trying to change that. After 15 years of work, the condition has been renamed to PMOS, or polyendocrine metabolic ovarian syndrome. The new name reflects the real driver of the condition: disruptions in hormones. But how much can changing a name really do? Click here to access resources about PMOS in multiple languages. Interested in more science? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Health experts stress importance of newborn screening
Screenings look for rare but serious health conditions that may not present right away and detect concerns like metabolic, endocrine and blood disorders.
Researchers rename PCOS to polyendocrine metabolic ovarian syndrome during Women’s Health
Weight loss surgery can improve reproductive health of women living with obesity
Metabolic bariatric surgery improves menstrual cycle frequency and symptoms of polycystic ovaries in women living with obesity, a new study from the University of Surrey reports.
Health records from 68 adults link plant-based grocery support to lower blood pressure and weight
Providing people with nutritious foods can improve the management of chronic metabolic diseases such as type 2 diabetes and hypertension. However, most studies of "Food Is Medicine" programs have only ...
Beyond the Mediterranean Diet: What’s Next for Gut Health?
Emerging data suggest Western dietary patterns may promote inflammatory gut changes, whereas traditional diets appear linked to more favorable metabolic effects.
New obesity discovery rewrites decades of fat science
Scientists have uncovered a surprising secret hidden inside fat cells that could reshape how we think about obesity and metabolic disease. A protein called HSL, long believed to simply release stored fat when the body needs energy, turns out to have a second job deep inside the nucleus of fat cells—helping keep those cells healthy and balanced. Even more surprising, people and mice missing this protein don’t become obese as expected; instead, they lose fat tissue in a dangerous condition called lipodystrophy.
Women with irregular periods should be checked for PMOS, NHS says
Polyendocrine metabolic ovarian syndrome is underdiagnosed and inconsistenly managed, according to Nice
Averly Health launches in UK to advance cardiometabolic care
Averly aims to improve patient care and access tenets surrounding cardiometabolic conditions, including obesity and type 2 diabetes.
Early childhood BMI trajectories predict later cardiometabolic health risks
Childhood obesity predicts later cardiometabolic disease, but single-time weight measures may miss dynamic growth information.
PCOS, a condition impacting 1 in 10 women worldwide, gets a new name
Polycystic ovarian syndrome, PCOS, is a common condition impacting women’s health and fertility that often gets underserved. A new name — polyendocrine metabolic ovarian syndrome — may help.
PCOS has been officially renamed PMOS, and it’s a momentous move
PCOS will now be known as PMOS (polyendocrine metabolic ovarian syndrome), and for Alice Klein, who has the conditon, it's been a long time coming
Overlooked plant proteins may boost gut health
Plant-based diets are good for you. They promote gut, immune, metabolic and cardiovascular health, in part by cultivating a diverse community of intestinal bacteria. These benefits have long been known ...
PCOS Gets a New Name in Landmark Women's Health Shift
By HealthDay Staff HealthDay ReporterFRIDAY, May 15, 2026 (HealthDay News) — A major women’s health condition is getting a new name—and experts say it could change how millions are diagnosed and treated worldwide. Polycystic ovary syndrome, or PCOS, will now be known as polyendocrine metabolic ...
What’s in a name? When it comes to women’s health, sometimes a lot
Polycystic ovary syndrome has been renamed polyendocrine metabolic ovarian syndrome. The change reflects the biological reality of this complex, whole-body disorder.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.#placement_1126610_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid1126610 = window.pid1126610 || rnd;var plc1126610 = window.plc1126610 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=1126610;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid1126610+';place='+(plc1126610++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help.Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
Oura, Counsel Health join CMS ACCESS model to test whether wearables and AI can improve chronic care at scale
Oura and Counsel Health are teaming up to participate in CMS' 10-year chronic condition management program, betting that continuous health data from Oura's smart ring paired with medical AI can hel | Counsel Health, an AI-native primary care company, plans to participate in CMS' ACCESS Model under the early cardio-kidney-metabolic track, with smart ring maker Oura serving as the preferred wearable partner.
Menopause health: Moving beyond hormones with metabolic interventions
While menopause’s major hormonal shifts are universally acknowledged, significant changes in women’s metabolic health at this time are frequently overlooked by traditional health care models. Digital wellness company Carrot’s AI platform Sprints is bridging this care gap with deeply personalized, data-driven lifestyle interventions for metabolism during this transition.
Cigna Group (CI) Could Be 56% Undervalued Following Its Health Sense Rollout
Health Sense rollout and what it could mean for Cigna Group stock Cigna Group (CI) has put its Health Sense platform at the center of a push to link health data, benefits and clinical support into a single experience for oncology and cardiometabolic patients. The model ties together information on medical history, behavioral health, pharmacy coverage, prior interactions and expected costs, then uses that context to tailor outreach and care coordination through existing Cigna Healthcare...
Your oral microbiome could affect your weight, liver and diabetes risk
An ambitious study has explored how the oral microbiome may affect our metabolic health, raising hopes that conditions like pre-diabetes could one day be screened for via a simple mouth swab
Finding Strength Through Sports While Living with Phenylketonuria
Episode 3 explores how teens with PKU balance the demands and realities of athletics while managing this metabolic condition.
New CKM guideline urges early weight talks to prevent health risks
Talk about healthy weight now to prevent serious heart, kidney and metabolic problems later, new treatment guideline says. #CKMsyndrome
Pregnancy complications linked to higher risk of cardiac and renal health conditions
Women with a complication in their latest pregnancy or a previous pregnancy face an elevated risk of developing cardiometabolic-renal conditions in subsequent years, suggests a U.K. study published online ...
Interconnected systems: Heart, kidney, metabolic health
When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems
ACC-AHA release first cardiovascular-kidney-metabolic syndrome guideline
Science shows the deep relationship between cardiac, kidney and metabolism issues that may impact up to 90% of the U.S. population.
Surgery still outperforms GLP-1 drugs in terms of heart health
Both treatment options are effective, but metabolic and bariatric surgery was linked to more significant cardiovascular risk reductions than GLP-1 medications.
Metabolic health emerges as key to brain and memory problems in bipolar disorder
While they share similar depressive and cognitive symptoms, the biological underpinnings of bipolar disorder and major depressive disorder are distinct. A novel study appearing in Biological Psychiatry: ...
Building the Backbone of Metabolic Health: Our Investment in Nourish
Nourish connects patients with registered dietitians for insurance-covered virtual sessions, handling credentialing, insurance verification, and more.
Study Identifies Potential Therapeutic Target Protein that Drives Metabolic Liver Disease Independent of Diet
The protein appears to cause liver damage by triggering an out-of-place antiviral immune response. Blocking this pathway can protect against liver injury in human cells and mouse models, even on a high-fat diet—paving the way for therapies to prevent liver damage.
PMOS vs. PCOS
The name change of a hormonal condition - from Polycystic Ovary Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS), could improve diagnosis and treatment.
Health Sense by Cigna Healthcare: How it works, AI, clinical support, and availability
Health Sense connects relevant data, context and clinical expertise to help Cigna Healthcare teams deliver more personalized, continuous support – so people can make informed decisions and act sooner. A phased rollout for eligible customers with oncology and cardiometabolic health needs will begin in early 2027.
Glyco Harmony Drops [URGENT REPORT 2026] GlycoHarmony Shocking Complete Scientific Breakdown of Benefits Everyone Is Talking
Explore the science behind Glyco Harmony. Get a detailed explanation of its ingredients, benefits, potential effects, and how the formula may support healthy glucose metabolism. Glyco Harmony Glyco Harmony New York City, NY, May 31, 2026 (GLOBE NEWSWIRE) -- As awareness of metabolic health continues to rise worldwide, consumers are increasingly searching for products that can help support healthy blood sugar levels, improve overall wellness, and complement healthy lifestyle choices. Learn what’s
Long-term "Food Is Medicine" program improves cardiometabolic health in adults
Providing people with nutritious foods can improve the management of chronic metabolic diseases such as type 2 diabetes and hypertension.
Samyang Roundsquare Launches Spindle, a Science-Led Metabolic Health Brand Focused on the Gut–Muscle Connection
Samyang Roundsquare announces the launch of Spindle, a science-led metabolic health brand with its debut product, Spindle Muscle+, to redefine how adults think about strength and aging. Spindle Muscle+ is powered by Akkermansia MYO™, a clinically studied strain shown to support muscle strength, through the gut.
Zepbound and Mounjaro may turn on the body’s calorie-burning brown fat
Tirzepatide, sold as Mounjaro and Zepbound, activated calorie-burning brown fat in obese mice, revealing a potential metabolic effect beyond appetite suppression. If confirmed in humans, the finding could help explain the drug’s powerful benefits and inspire more comprehensive treatments for obesity and diabetes.
From PCOS to PMOS: New name reflects women’s metabolic health
Global multidisciplinary health professionals and organizations have updated the name polycystic ovary syndrome (PCOS) to polyendocrine metabolic ovarian syndrome (PMOS), arguing that the former is “inaccurate.” They critique that the old name implied greater focus on pathological ovarian cysts, contributing to slower diagnosis, stigma, and limited research and policy framing for the 170 million women living with the condition.
Coffee drinkers have less fat, more muscle, and surprising hormone differences
Coffee drinkers may be getting more than an energy boost. A Finnish study found that people who drank more coffee tended to have less total and abdominal fat, more muscle, and healthier metabolic markers despite having similar BMIs. Higher coffee intake was also linked to lower levels of certain amino acids associated with insulin resistance and type 2 diabetes risk.
3 minutes of sprinting does something 90 minutes of exercise does not
A few minutes of sprinting may reshape the bloodstream far more dramatically than a much longer moderate workout. Six 30-second sprints altered nearly a quarter of the blood proteins measured and more than 200 metabolites, while 90 minutes of moderate cycling produced far smaller immediate changes. Many of the proteins affected by sprinting were also associated with lower risks of obesity, type 2 diabetes, and other metabolic diseases.
Network topology of the gut microbiome associates with metabolic health in obesity
Nature Communications - Here, the authors show that microbiome network topology associates with metabolic health across obesity phenotypes, with reduced connectivity in metabolically unhealthy...
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Averly Health launches to transform cardiometabolic care in the UK
Joint venture between Reset Health and Pharmacy2U creates the first and only fully integrated national cardiometabolic care provider.Averly Health will set a new standard for access and outcomes to transform the population’s health across chronic diseases like obesity, type 2 diabetes and cardiovascular disease.Averly Health combines Reset Health’s specialist cardiometabolic clinical expertise with Pharmacy2U's market-leading digital prescribing and pharmacy infrastructure to deliver a seamless
Harvard Business School announces 2026-2027 Blavatnik Fellows
Harvard Business School (HBS) has named its 2026-27 Blavatnik Fellows. The fellowship offers HBS alumni and Harvard-affiliated postdoctoral researchers the opportunity to advance new life science technology ventures and develop their leadership talents during a 12-month fellowship year. To date, Blavatnik Fellows have founded 50 biomedical companies developing innovations including gene writing technologies, engineered cell therapies, oral biologic drug delivery platforms, AI-enabled digital health solutions, and therapeutics for cancer, neurological, and metabolic diseases. Collectively, Fellows have raised more than $800 million in private and public capital to advance their ventures.
Israeli scientists find ‘multitasking’ gene controls mood and metabolism in mice
Weizmann Institute researchers find Orthopedia gene plays critical role throughout life after aiding in-utero brain development; study may help treatment of anxiety and metabolic disorders
One of America's Most Widely Consumed Ingredients Linked to Metabolic Changes And Obesity
"It's not the oil itself ... It's what the fat turns into inside the body."
Dirty soda drinks are everywhere, but doctors warn of health risks: 'Metabolic disaster'
Dirty sodas combine soft drinks with syrups, creamers and fruit juices, delivering up to 400 calories and 70 grams of sugar per drink, doctors warn.