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NI's O'Neill ruled out of Nations League matches
Arsenal forward Ceadach O'Neill is ruled out of Northern Ireland's final two Nations League fixtures against Ukraine in Belfast and Hungary in Budapest.
Rockaway Beach: Not Business as Usual
By Mayor Charles McNeilly What can a small coastal community of fewer than 1,500 residents teach other towns about economic development, tourism, and quality of life? Quite a lot, it turns…
Errors frustrate fastidious O'Neil
Analysis from Ipswich's 2-1 home defeat to Bournemouth
Cross snatch late win over Gowna to progress in Ulster
Rian O'Neill's last-gasp score secures a 1-22 to 2-18 comeback win for Crossmaglen in their Ulster Club SFC quarter-final against Gowna at Breffni Park.
Mötley Crüe singer Vince Neil’s girlfriend arrested for domestic assault
LOS ANGELES — The girlfriend of Mötley Crüe front man Vince Neil was arrested Sunday for reportedly striking the singer. Rainbow Hannah Andreani, 45, was booked in Williamson County, Tennessee,
Health Pulse: November 6. 2026
The O’Neill Institute believes that the law is a fundamental tool for solving critical health problems.
Woods Hole research ship heads to Lake Superior to hunt neutrinos
The R/V Neil Armstrong is making its first Great Lakes voyage, carrying Cape Cod science into fresh water for an experiment probing the universe.
Lack of clinical edge was a big problem
Millwall boss Alex Neil speaks to BBC Radio London after the 3-0 defeat at Birmingham City.
“I Don’t Know If I’m Willing to Do It Just to Fight” – UFC Fans May Have Seen the Last of Beneil Dariush Inside the Octagon
Fans may have already seen the last of Beneil Dariush inside the Octagon. The veteran lightweight has endured a difficult stretch lately, losing four of his last five UFC fights, with all four defeats coming by knockout. Most recently, Dariush was stopped by Quillan Salkilld at UFC Perth in May 2026. Before that, he suffered …
The dangerous myth of the well-meaning health guru
In healthcare, a warm heart is no substitute for a trained mind. Banned Australian naturopath Barbara O’Neill built a global empire on the defense that she "just wants to help," but good intentions mean nothing when uncredentialed health advice causes real-world harm.
A NASA Telescope Is Predicted to Crash Back to Earth Within Hours
The space agency estimates that there is a one-in-2,100 chance that debris from the Neil Gehrels Swift Observatory could injure someone on the ground.
MitoRx Therapeutics Appoints Neil Anderson as Chief Business Officer
Neil joins from Novo Nordisk and brings more than 20 years of experience in business development and strategic transactionsAppointment strengthens MitoRx’s business development capabilities as the Company advances MTRX31 towards the clinic for metabolically unhealthy obesity Harwell Oxford, UK – 3 November 2026: MitoRx Therapeutics (“MitoRx”), a biotech company targeting the restoration of healthy mitochondrial metabolism in high-risk obesity, today announces the appointment of Neil Anderson, Ph
Early Favourite Emerges to Replace Martin O'Neill at Celtic
An early favourite has emerged to replace Martin O'Neill at Celtic if the manager chooses to depart.
NASA’s Swift Observatory to Re-Enter Atmosphere
NASA’s Neil Gehrels Swift Observatory is expected to re-enter Earth’s atmosphere on Wednesday, Nov. 4, almost 22 years after launch. At launch, Swift was a
Alim McNeill Has Detroit’s Interior Pass Rush Back in Business
Alim McNeill has become the interior pass rusher Detroit has not had in a very long time. #OnePride
Alim McNeill Has Detroit’s Interior Pass Rush Back in Business
Alim McNeill has become the interior pass rusher Detroit has not had in a very long time. #OnePride
Kansas City Chiefs loss to Denver Broncos will come back to haunt them as Bo Nix answers critics again
The Kansas City Chiefs suffer their second straight defeat after a dramatic finish to Sundays game against the Denver Broncos; listen to Sky Sports NFLs Neil Reynolds and Jeff Reinebold as they reflect on Week Eight in the NFL on Inside the Huddle podcast
Neil Garg wins 2026 Science and Education Pioneer Award
Indian American UCLA professor honored for inspiring public engagement with science education, particularly among young people.
How one family gave a critical boost to gene therapy research
A family affected by Sanfilippo syndrome raised millions of dollars for research. The Food and Drug Administration just approved a gene therapy the support helped make possible.
While mud-coring in Baffin Bay, scientists accidentally found the marks of a mile-thick ice shelf that blocked three massive ice sheets
A 2023 mud coring excursion mapped seafloor marks of an ice shelf up to 1.3 miles thick that filled Baffin Bay about 20,000 years ago.
Celtic Boss Makes Brutally Honest Jota Admission
Martin O'Neill has made a brutally honest admission about Jota, with the Celtic winger recently returning after a 18-month absence through injury.
Watch: McNeil vs. Westwood football live
McNeil and Westwood both enter Friday's District 25-6A matchup searching for their first district victory of the season at Kelly Reeves Athletic Complex.
Chris Sutton Slams Mistake Martin O'Neill Keeps Making
Chris Sutton has slammed a mistake that Martin O'Neill constantly keeps making, which is hurting Celtic.
2026-2027 Audree V. Fowler Fellows in Protein Science
Graduate students Lenka Milojević (Zhou group), Akshaya Narayanasamy (Lindert group), Sarah Singleton (Conway group), and Janet Zhong (Feigon group) have been selected as 2026–27 Fowler Fellows and shared their research at a special event on Oct. 13, 2026. 2026-27 Fowler Fellows – Sarah Singleton, Lenka Milojević, Janet Zhong, and Akshaya Narayanasamy. Akshaya Narayanasamy and Prof. Steffen Lindert. Sarah Singleton and Prof. Stuart Conway. Janet Zhong and Prof. Juli Feigon. About the 2026-27 Audree Fowler Fellows in Protein Science Lenka Milojević is a fifth-year Biophysics Ph.D. candidate in the lab of Professor Z. Hong Zhou at UCLA. As an undergraduate at Maastricht University, she studied the structural basis of Mycobacterium tuberculosis virulence and amyloid-β fibril nucleation in the lab of Professor Peter Peters. She completed her bachelor’s thesis research at UCLA in the lab of Professor David Eisenberg, focusing on amyloid disaggregation, before beginning her doctoral studies. In the Zhou lab, Lenka uses cryo-electron tomography to visualize and characterize membrane-associated protein assemblies across a range of viral and cellular systems. Akshaya Narayanasamy is a fifth-year Ph.D. student in the Department of Chemistry and Biochemistry at UCLA, mentored by Professor Steffen Lindert. She earned her B.S.-M.S. in Chemistry from the Indian Institute of Science Education and Research, Thiruvananthapuram, where she worked in Professor Mahesh Hariharan’s lab investigating how single-atom substitutions influence crystal packing and charge transport behavior. She received her M.S. in Physical Chemistry from The Ohio State University before moving with the Lindert lab to UCLA. At UCLA, Akshaya develops integrative modeling methods that combine deep learning and Rosetta with experimental data, such as ion mobility mass spectrometry and cryo-EM, to improve protein structure prediction. Her current work focuses on developing an experimentally guided diffusion model and designing de novo protein binders with potential antibacterial activity. Ultimately, she aims to bridge AI-based structure prediction and experimental data to make computational protein models more reliable for drug discovery and therapeutic design. Sarah Singleton is a 4th year BMSB student, working in Professor Stuart Conway’s lab. She earned her B.S. in Biochemistry at Simmon University (Fenway, MA). Her research is centered on drugging the previously undruggable class of proteins—transcription factors. Zinc finger (ZF)-containing transcription factor proteins typically contain multiple ZF motifs, but little is known about the principles that govern the recognition of multi-ZF arrays by immunomodulatory imide drugs (IMiDs). In a multi-ZF array that contains several potentially targetable ZFs, which will be accessible and why? How does the surrounding protein architecture inform IMiD recognition? Sarah’s research aims to utilize her findings on the fundamental principles of ZF recognition to design IMiD therapeutics for transcription factors involved in health and disease. Janet Zhong is a fourth-year BMSB student, working in Professor Juli Feigon’s laboratory. She received her BSc and MRes from Imperial College London. At UCLA, Janet combines cryo-electron microscopy (cryo-EM) and biochemical approaches to investigate how proteins and RNAs assemble into ribonucleoprotein structures. Her research focuses on telomerase, the enzyme that maintains chromosome ends, with interests in its structure, assembly, and mechanisms. She has also worked on capturing the cryo-EM structure of a small bacterial non-coding RNA called raiA motif RNA. About Dr. Audree Fowler A strong supporter of the basic sciences and medicine at UCLA, alumna Dr. Audree Fowler (B.S. ’56 chemistry, Ph.D. ’63 biochemistry) established the Audree V. Fowler Fellows in Protein Science in 2008. Fowler was Director UCLA Protein Microsequencing Facility from 1984-1999 and is a Researcher Emeritus of the UCLA Department of Biological Chemistry. She is one of the first four women to receive a Ph.D. from the UCLA Department of Chemistry & Biochemistry. In 2018, the women were awarded the department’s 2018 Alumni Legacy Awards in recognition of their achievements in life, and generous support and service to UCLA. “The sciences gave me a great life. Now I want to help others have access to the same opportunities I enjoyed,” Fowler explained when she established the Fowler Fellowships endowment. Applications for the fellowships are solicited from graduate students in the Molecular Biology Interdepartmental (MBI) Ph.D. Program, Biological Chemistry, and Chemistry & Biochemistry Departments. In addition to presenting their research at a special seminar, the recipients each receive a $5,000 award. Previous Fowler Fellows from the UCLA Department of Chemistry & Biochemistry 2025-26 – Nikki Cheung (Clubb Group), Jonathan Jih (Zhou Group), Eileen Olivares (Loo Group), and Lily Taylor (Rodriguez Group) 2024-25 – Andrew Goring (Clubb lab), Eric Pang (S. Clarke and Rodriguez labs), and Miranda Villanueva (Backus lab) 2023-24 – Alexandra Turmon (Backus lab), Cindy Wang (S. Clarke and C. Clarke labs) 2022-23 – Cody Gillman (Gonen lab), Declan Evans (Houk lab), Troy Lowe (S. Clarke lab), Ashley Julio (Backus lab), and Alex Stevens (Hong Zhou lab) 2021-22 – Weixian Deng (Wohlschlegel/Plath labs), Yi Xiao “Sean” Jiang (Eisenberg lab), Maria Flores (Rodriguez lab), Carter Lantz (Loo lab), and Logan Richards (Rodriguez lab). 2020-21 – Janine Fu (Loo lab), Calina Glynn (Rodriguez lab), and Jiahui Lu (Eisenberg lab) 2019-20 – David Boyer (Eisenberg lab), Orlando Martinez (Clubb lab) and John Muroski (Loo lab) 2018-19 – Scott McConnell (Clubb lab), Kevin Murray (Eisenberg lab), Rebeccah Warmack (S. Clarke lab) 2017-18 – Michael Hughes (Eisenberg lab), Yuxi Liu (Yeates lab), Kanishk Jain (S. Clarke lab) 2016-17 – Brendan Amer (Clubb Lab) and Jeff Vinokur (Bowie Lab) 2015-16 – Henry Chan (Feigon lab), Smriti Sangwan (Eisenberg lab), Nicholas Woodall (Bowie lab) 2014-15 – Dan McNamara (Yeates lab) 2013-14 – Alex Jacobitz (Clubb lab), Alexander Patananan (S. Clarke lab), Carly Ferguson (Loo lab) 2012-13 – Letian Xie (C. Clarke lab), Anni Zhao (Eisenberg lab) 2011-12 – Timothy Anderson (Clubb lab), Soohong Kim (Weiss lab) 2010-11 – Zeynep Durer (Reiser lab), Cecilia Zurita-Lopez (S. Clarke lab) 2009-10 – Luki Goldschmidt (Eisenberg lab), Kristofer Webb (S. Clarke lab), Sheng Yin (Loo lab) 2008-09 – Nathan Joh (Bowie lab), Neil King (Yeates lab) Photos courtesy of Helen Houldsworth, the Molecular Biology Institute.
O'Neill agrees with McGregor about Celtic issues
Manager Martin O'Neill says he is in "full agreement" with captain Callum McGregor's assessment of Celtic's issues, but insisted they will "sort it out".
Tyler O’Neill’s 2026 season was another letdown
Another injury-plagued season for O’Neill leaves the Orioles outfield with even more holes to fill.
Neil Garg named recipient of the 2026 Science and Education Pioneer Award
Distinguished Professor Neil Garg has been named the recipient of the UCLA College, Division of Physical Sciences’ 2026 Science and Education Pioneer Award for his contributions to science and education. He will be honored at Exploring Your Universe, UCLA’s free science festival, on Sunday, Nov. 8, in the Court of Sciences. The ceremony and Garg’s remarks will take place at noon in Young Hall CS50, and will be livestreamed here. He will also give a family-friendly lecture, “Organic Chemistry in the Movies”, at 3 pm in Young Hall CS76. The Pioneer Award recognizes individuals who have made significant contributions to science and inspired public engagement with science education, particularly among young people. Previous award recipients include astronaut and UCLA alumna Dr. Anna Lee Fisher (2017), mathematician and UCLA alumna Danica McKellar (2018), actress, author and neuroscientist Dr. Mayim Bialik (2019), Nobel Prize-winning astrophysicist Andrea Ghez (2020) and UCLA mathematics professor and Fields Medalist Terence Tao (2025). Garg is the Distinguished Kenneth N. Trueblood Professor of Chemistry and Biochemistry at UCLA. He received his B.S. from New York University and Ph.D. from Caltech, and completed postdoctoral studies at UC Irvine before joining the UCLA faculty in 2007. Garg is an internationally recognized organic chemist whose research focuses on developing new chemical reactions, often challenging long-standing rules in chemistry. He has published more than 200 scientific papers. Beyond his research accomplishments and award-winning classroom teaching, Garg is passionate about making chemistry accessible and engaging for students and the broader public. He has developed innovative websites, apps, and games used in more than 175 countries, authored The Organic Coloring Book series, and created outreach programs that introduce children to chemistry, including his popular Chem Kids camp. His honors include the Royal Society of Chemistry’s Horizon Prizes for both research and education, the Cherry Award for Great Teaching, the California Professor of the Year Award, and the AAAS Mani L. Bhaumik Award for Public Engagement with Science. In 2026, he received the Royal Society of Chemistry’s prestigious Centenary Prize.
Neil Young sues Trump for playing Rockin' in the Free World at a rally without a licence
The Canadian-American musician sued Trump in 2020 over unauthorised use of song at a political event.
Neil Young sues for the second time over Trump’s use of ‘Rockin’ in the Free World’
The lawsuit seeks $10 million for what it calls damage to the rock star’s “reputation and brand as a result of the implication that he supports Donald J. Trump in any way.”
NASA's Swift observatory ends 22-year mission to study the most powerful explosions since the Big Bang
NASA's Neil Gehrels Swift Observatory has officially ended its mission after more than 20 years, as it approaches a fiery reentry through Earth's atmosphere.
Pasifika Entertainment Advancement Komiti Announces 2026 Writers Fellowship Class
The Pasifika Entertainment Advancement Komiti has named the third cohort of its annual PEAK Writers Fellowship. This year’s cohort includes Kanani Koster, Erin Lau, Sean Oketani, Neil Tinkham and Poua...
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame
Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.
Book review: Former resident writes a good dam novel
At 42, West Virginia native Matthew Neill Null is distinguishing himself as a writer with Pulitzer potential.
NASA’s Swift Mission Ends, Leaves Behind Scientific Bonanza
NASA’s Neil Gehrels Swift Observatory has ended its science mission now that the spacecraft is orbiting less than 171 miles (275 kilometers) above Earth’s
“It was a tough evening, but I can’t ask for any more from the players,” Martin O’Neill
Martin O’Neill spoke to the mainstream media last night after Celtic lost a fourth successive match in European football, this time going down 2-1 to Celta Vigo at Celtic Park…Martin O’Neill, Ma...
Do Stormont politics stifle the non-sectarian parties?
Letters: Responding to an editorial, Boyd Black deplores Labour’s policy of not fielding candidates in Northern Ireland. Plus a letter by Declan O’Neill
COROS DURA 2 SOLAR Review: Big Upgrade, Bigger Price
Neil's latest review digs into his experience with the COROS DURA 2 Solar, a new bike computer that claims to improve on the first model...
'World Class' - Celtic Player Solution to Martin O'Neill's Problems
The Celtic player has one 'world class' attribute that will remind fans of a certain Kyogo Furuhashi.
George W. Bush’s Brother Neil Bush Breaks G.O.P. Ranks to Vote for James Talarico in Texas
Neil M. Bush, a brother of former President George W. Bush, expressed “deep concern about Ken Paxton’s record” and said he voted for James Talarico, the Democrat running for Senate in Texas.
National Science Foundation leader Brian Stone to retire with no clear replacement in sight
President Donald Trump's nominee to replace Stone, James O'Neill, has yet to have a confirmation hearing in the senate, leaving the future leadership of the NSF unclear
O'Neill clashes with committee members over Garvaghy Road
The First Minister Michelle O'Neill has clashed with unionist politicians at a Stormont committee over her involvement in protests on the Garvaghy Road blocking an Orange Order parade last month.
Celtic Boss Confirms Bad News for Celta Vigo Game
Martin O'Neill has confirmed some bad news for Celtic heading into the Europa League game against Celta Vigo.
‘Keep away from the doctor’: a visit to an influencer’s wellness event, where the advice could kill
Barbara O’Neill, identified as a risk to public safety in Australia, dismisses antibiotics, vaccines and scientifically proven cancer treatment at UK conference
Police investigating death of man found unconscious in business parking lot
Champaign police officers responded to the 700 block of North Neil St. at 6:37 a.m. for a report of a man down, Lt. Ben Newell told The News-Gazette.
Antonio Banderas, Nicolas Cage to star in 'True Detective' season 5
Nicolas Cage attends 'The Surfer' photocall at the 77th annual Cannes Film Festival at Palais des Festivals on May 17, 2024, in Cannes, France. (Neilson Barnard/Getty Images) | Antonio Banderas
Neil Howard joins Bespoke Sports & Entertainment
Bespoke Sports & Entertainment is augmenting its senior staff, with the hire of Neil Howard as VP experiential. Howard, who was at MKTG from 2006-2025 rising to SVP, working on Toyota and other accounts will be based in Charlotte and become part of Bespoke’s senior leadership team.
Analysing the Role of Summer Signing Dan Neil at Rangers
With Dan Neil making an exceptional start to life at Ibrox since joining Rangers from boyhood club Sunderland of the Premier League in the summer, we analyse his current role in the team.
Arsenal Name Two Teenagers in Champions League Squad vs Lille
Arsenal academy pair Ceadach O’Neill and Maalik Hashi are understood to have been included in the matchday squad for tonight’s Champions League clash with Lille.
Real Reason Celtic Player Got Dropped vs Motherwell
Martin O'Neill has shared the real reason the Celtic player was dropped in the game against Motherwell.
William Shatner says he learned about ‘the world of homosexuality’ from kinky Alexander Skarsgård movie
William Shatner says he made a connection between a playful shove in the face from his friend Neil deGrasse Tyson and Alexander Skarsgård’s erotic drama ‘Pillion’ — specifically, about ‘the world of homosexuality.’
‘The Rookie: North’ sets Nathan Fillion, Melissa O’Neil crossovers, Dulé Hill joins ‘Rookie’ season 9
Nathan Fillion, Melissa O’Neil, and Eric Winter are Washington-bound for crossover appearances on ‘The Rookie: North,’ while the mothership adds Dulé Hill and Troian Bellisario for season 9.
Millwall boss Alex Neil reacts to win at Preston
Millwall boss Alex Neil speaks to BBC Radio London after their 1-0 win against Preston.
Ipswich Town vs Fulham – Predicted lineup and team news
Ipswich Town host Fulham at Portman Road on Saturday seeking a third win of the season against opponents yet to win one. Gary O’Neil’s side are 11th on six points, while Fulham are 19th on two. Ip...
Eminem appears on new track 'Madara' with rappers Ez Mil, Hideyoshi
DETROIT — Eminem appears on "Madara," a new track from Philippines-born rapper Ez Mil, released overnight on Friday, Oct. 9. "Madara" also features Tokyo rapper Hideyoshi and voice actor Neil
Janesville News Gazette editor discusses ballot referendums, new city leadership and area business growth
Janesville journalist Neil Johnson discusses ballot referendums, new city leadership and agriculutre growth in the small city of Evansville.
Griffin College of Business Hosts Third Annual Internship Open House
More than 150 students connected with 10 employers during the Neil Griffin College of Business Internship Open House. Students and recruiters came together on campus to discuss internships, career pat
Anthony Joseph Confirms Celtic Behind-the-Scenes News
There is a behind-the-scenes update on Celtic amid all the speculation around Martin O'Neill's future at the club.
A Nobel Prize for IceCube: Drexel Physicists Reflect on the Science and What Comes Next
The 2026 Nobel Prize in Physics recognized Francis Halzen for his work on the IceCube Neutrino Observatory. Naoko Kurahashi Neilson, PhD, a professor in Drexel University’s College of Arts and Scie…
Arlington maritime startup raises $140M in Series B funding
Arlington County maritime startup Quartermaster AI raised $140 million in Series B funding to grow headcount and recruit new vessels.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Blue Jays Handed Clear Offseason Message on Pirates’ Oneil Cruz
After reaching the World Series last year, the Toronto Blue Jays failed to reach the postseason this year. As a result, the Blue Jays’ front office will need to bolster the team if it wants to return to the Fall Classic. Vladimir Guerrero Jr. had an awful 2026 season by his standards, hitting .260 while […] The post Blue Jays Handed Clear Offseason Message on Pirates’ Oneil Cruz appeared first on HEAVY.
O'Neill Institute Announces New Leadership and Two New Centers, Ushering in a Dynamic New Era for Health Law
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What do the numbers tell us about Hogh's Celtic start?
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O'Neill left 'baffled' by refereeing in late win
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Northern Ireland XI vs Georgia – Predicted lineup and team news
Northern Ireland are ready to kick off their UEFA Nations League Group B journey with an away fixture against Georgia on Friday at the Boris Paichadze Dinamo Arena.Michael O’Neill’s side arrive in...
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How to watch Lake Travis vs McNeil high school football
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Petrov voices concerns about nature of Celtic’s transfer business
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Petrov voices concerns about nature of Celtic’s transfer business
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Despite many putting two-and-two together following Roy Keane's appearance at Sunday's defeat by Rangers, the former Celtic midfielder and friend of under pressure current boss Martin O'Neill made it abundantly clear on the most recent Stick to Football podcast he would never attend a game with the ulterior motive of replacing a manager. Reacting to Celtic's defeat by Rangers, Roy Keane remarked to Celtic AM that it was the "ups and downs of football".
Keane presence at Celtic Park defeat played down
Roy Keane's appearance at Celtic Park as Martin O'Neill ponders his future as manager is played down as Aberdeen's Findlay Marshall expresses relief at not being sent out on loan.
Michael Carrick believes Man Utd can still have big season despite equalling club's worst Premier League start- Paper Talk
Latest transfer news and headlines include: JJ Gabriels reason behind wanting to leave Manchester United; Andoni Iraola continuing to want more from Alexander Isak despite his winning goal against Bournemouth; Martin ONeill ponders his future as Celtic boss
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Celtic 'passive' & 'in trouble'
Celtic sustained a third defeat in a row after Rangers left Glasgow's east end with a 1-0 win in Sunday's Scottish Premiership match. For Martin O'Neill's side, it followed last Sunday's 3-0 League Cup loss away to Rangers and a midweek Europa League defeat at home to Ferencvaros. Former Celtic captain Scott Brown was on punditry duty for BBC Scotland and shared his thoughts on the game.