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Exclusive: Numeracle Raises $28M To Keep Legitimate Business Calls From Spam Label

Numeracle, a McLean, Virginia-based company that verifies businesses and links their identities to the phone numbers they use to contact customers, has raised $28 million from Edison Partners to help businesses whose calls are incorrectly labeled as spam or blocked by phone carriers.

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Oct 28 • 8:00 AM EDT • Business • news.crunchbase.com
Brewers' Chourio Ties Ruth's 98-Year-Old World Series Record

The 22-year-old phenom matched Babe Ruth's historic 1928 mark, igniting the Milwaukee Brewers' offense in the World Series.

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Oct 28 • 8:00 AM EDT • Sports • sports.yahoo.com
Could aliens have visited Earth before humans developed civilization? Some scientific clues keep the question alive

Earth’s deep past leaves plenty of unanswered questions. None currently proves an alien visit, but scientists know the geological record does not preserve everything.

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Oct 28 • 7:17 AM EDT • Science • yahoo.com
Chiefs News: Harrison Butker may have competition amid struggles

The latest Chiefs news, brought fresh to you every morning!

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Oct 28 • 6:30 AM EDT • Sports • sports.yahoo.com
More voters are leaving party labels behind, as national politics reshape in WV

A growing number of West Virginia residents choosing to register without a political party, a shift that comes as the state’s political identity continues to change. Interviews with voters and political observers suggest that, for some, leaving a party is less about abandoning politics and more about feeling that neither major party fully represents their beliefs.

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Oct 28 • 6:00 AM EDT • Politics • wvgazettemail.com
Fed, Alphabet, Microsoft, Amazon set up 48-hour stock market test for AI

The Fed will set the rate backdrop, while Alphabet, Microsoft, and Amazon face fresh questions about AI spending.

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Oct 28 • 5:50 AM EDT • Business • businessinsider.com
Better than Brian Lara? Dinesh Karthik decodes the science behind Vaibhav Sooryavanshi’s massive backlift punch and brute power

Dinesh Karthik broke down the biomechanics behind Vaibhav Sooryavanshi's power-hitting.

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Oct 28 • 3:38 AM EDT • Science • sports.yahoo.com
Cancer and family finances make health care debate personal for Nunn, Trone Garriott

Their mothers’ cancer experiences made health care personal in the Nunn–Trone Garriott debate. Here’s what they said about the Affordable Care Act and affordability.

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Oct 28 • 12:29 AM EDT • Health • kcci.com
Human Evolution and Disease: How Ancient DNA Shapes Modern Health Risks

Ancient DNA and evolutionary medicine help explain how inherited genetic variants interact with changing environments to influence modern disease risk. Neanderthal ancestry, metabolic variation, and evolutionary trade-offs provide insights into immunity, obesity, type 2 diabetes, and aging.

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Oct 28 • 12:06 AM EDT • Health • news-medical.net
Disinformation videos, likely from Russia, are exploiting real people to malign Senate candidates

Social media videos believed to be linked to Russia are misusing real people’s names and photographs to spread disinformation about two Democratic Senate candidates.

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Oct 27 • 8:15 PM EDT • Politics • ksat.com
Yankees' David Bednar Gets $55 Million Contract Prediction

The New York Yankees have some key players hitting the open market this offseason

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Oct 27 • 8:07 PM EDT • Sports • sports.yahoo.com
Political ad blitz fills Texas airwaves as Election Day nears
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Oct 27 • 6:59 PM EDT • Politics • ksat.com
The Wake Forest Refocus

Wake Forest is done resting for the season, and it is time to refocus. After a bye week, the Demon Deacons are 6-1 overall and 4-1 in the conference with five games left in the season. They are home Saturday against the Virginia Cavaliers, who come into Winston-Salem 4-4 overall and 2-3 in conference play. …

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Oct 27 • 5:19 PM EDT • Sports • sports.yahoo.com
Amo Celebrates $1.2 Million Federal Investment in Cumberland Stormwater Improvements to Protect Local Businesses and Jobs

Cumberland, RI – TODAY, Congressman Gabe Amo (D-RI-01) joined local leaders today to celebrate the completion of a $1.2 million stormwater infrastructure project along Industrial Road, helping Cumberland address chronic flooding in its largest commercial area and better protect the businesses, workers, and infrastructure that keep its economy moving.

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Oct 27 • 3:35 PM EDT • Business • amo.house.gov
Former NWSL player says league culture pressured athletes to support political messages they opposed

Elizabeth Eddy says NWSL players faced pressure to wear political shirts or risk teammate backlash, describing a culture with no room for dissent.

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Oct 27 • 3:04 PM EDT • Politics • foxnews.com
Milk Protein Peptide Eases Blood Sugar Problems In Diabetic Mice

A dairy protein fragment calmed blood sugar swings and inflammation in diabetic mice, pointing to a possible food-based tool for blood sugar support.

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Oct 27 • 2:05 PM EDT • Health • draxe.com
My divorce made headlines. Now I help survivors of toxic relationships tell their stories.

Elizabeth Chambers on rebuilding after her high-profile divorce from Armie Hammer, raising her kids and what survivors have taught her through her ID series "Toxic."

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Oct 27 • 2:04 PM EDT • Entertainment • yahoo.com
Report: Seahawks Land Quenton Nelson Ahead of Trade Deadline

The Colts are reportedly sending eight-time Pro Bowler Quenton Nelson to Seattle, and the price was small. #NFL

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Oct 27 • 12:52 PM EDT • Sports • sports.yahoo.com
Mountain lion found at Moab business tranquilized, relocated by wildlife officials

A mountain lion spotted at a Moab business was successfully tranquilized and will be relocated by wildlife officials.

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Oct 27 • 12:11 PM EDT • Business • kutv.com
It Ain’t Just Sports: Trailblazer and diving coach, Diane Maiese

In this episode: We sit down with Diane Maiese, the first AND only Black woman to win an NCAA Championship and be named a four-time, all-American, in diving.

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Oct 27 • 12:11 PM EDT • Sports • 12onyourside.com
Funding plan to bring Sphere entertainment venue to National Harbor passes Prince George's County Council
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Oct 27 • 12:08 PM EDT • Entertainment • yahoo.com
Scientists invent implant that can transform sugar in the blood to treat type 2 diabetes

An experimental medical device uses a tiny amount of electricity to spark a chemical reaction and remove extra sugar from the bloodstream.

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Oct 27 • 11:30 AM EDT • Science • livescience.com
Trump returns to Texas for a high-stakes push to keep the state in Republican hands

President Donald Trump is in Texas to support Republican Ken Paxton's U.S. Senate campaign against Democrat James Talarico.

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Oct 27 • 11:19 AM EDT • Politics • ksat.com
Nathan Fielder's Elizabeth Holmes documentary 'You Can See Everything' ended, but the story didn't. Here's what's happened since.

Warning: Don’t read this article if you haven’t seen Fielder's critically acclaimed film, as it contains plenty of spoilers.

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Oct 27 • 10:25 AM EDT • Entertainment • yahoo.com
Vera Health secures $28.5M series A for AI-driven clinical search engine

Clinical artificial intelligence search engine Vera Health secured $28.5 million in series A funding to accelerate and expand its platform. | Vera Health’s platform scans more than 60 million peer-reviewed publications, clinical guidelines, consensus statements and drug labels, executives say.

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Oct 27 • 9:00 AM EDT • Health • fiercehealthcare.com
Syracuse Football: First November Kickoff Now Scheduled

The Orange will host the Clemson Tigers at the JMA Wireless Dome, looking to beat their rivals for the second straight year.

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Oct 27 • 8:27 AM EDT • Sports • sports.yahoo.com
⚾️ Y! Sports AM: Brewers 10, Rays 1

Milwaukee took a commanding 3-0 World Series lead during the 33rd Sports Equinox.

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Oct 27 • 7:53 AM EDT • Sports • sports.yahoo.com
You Can See Everything and the science of spotting liars

It feels like everyone we know is talking about the new documentary You Can See Everything. It tracks the effort of comedian and documentarian Nathan Fielder to suss out how deceptive Elizabeth Holmes, disgraced founder of the company Theranos, is. And after watching the film, we all left the theater wondering -- what could we see? How possible is it to ever really spot someone lying? So we of course called up an expert in deception and counter-deception research, Maria Hartwig, a professor of psychology at CUNY, the City University of New York. For more on sussing out a liar, check out our episode about what's wrong with the polygraph. Interested in more deep dives on the science behind pop culture blockbusters? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.

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Oct 27 • 3:00 AM EDT • Science • npr.org
High-Signal Publisher
How Trump’s ‘little detour’ to Iran became a roadblock in the midterm elections

When President Donald Trump launched his war on Iran, he said it would last a matter of weeks.

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Oct 27 • 12:04 AM EDT • Politics • ksat.com
Healthcare costs are on the rise in Minnesota, a top issue for voters. How much more could you pay?
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Oct 26 • 9:14 PM EDT • Health • cbsnews.com
High-Signal Publisher
Olympiacos vs. Rennes Could Be Moved Due to French Strike

Olympiacos' Europa League match against Rennes could be moved to Nov. 4 due to a general strike and protests in France. Here's what we know.

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Oct 26 • 9:09 PM EDT • Sports • sports.yahoo.com
Elizabeth Debicki’s reaction to seeing Alexander Skarsgård in full-frontal “Wicker” costume was to turn ‘bright red’

The actress encountered her leading man as he was in the water.

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Oct 26 • 8:30 PM EDT • Entertainment • yahoo.com
Trump campaigns in Mississippi, highlighting Republicans\' challenges

President Donald Trump is campaigning in Mississippi as both parties make their closing arguments ahead of midterm elections in eight days. And the Mississippi Democrat that Trump wants defeated stopped

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Oct 26 • 8:19 PM EDT • Politics • lancasteronline.com
More voters are leaving party labels behind, as national politics reshape West Virginia

MORGANTOWN – Christine Riley spent most of her life as a Democrat, following a political affiliation that had been part of her family for generations. But after the Jan. 6, 2021, attack on the U.S. Capitol, the 63-year-old retired 911 dispatcher decided she no longer wanted to belong to either major political party. Riley, a […]

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Oct 26 • 8:00 PM EDT • Politics • dominionpost.com
Trump campaigns Mississippi, highlighting Republicans\' challenges

President Donald Trump is campaigning in Mississippi as both parties make their closing arguments ahead of midterm elections in eight days. And the Mississippi Democrat that Trump wants defeated stopped

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Oct 26 • 7:48 PM EDT • Politics • lancasteronline.com
Billy Evans' 'You Can See Everything' shower scene was his idea

Billy Evans — the partner of Theranos founder Elizabeth Holmes — asked the 'You Can See Everything' team: 'Want to film me showering?'

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Oct 26 • 7:37 PM EDT • Entertainment • latimes.com
Why did the Patriots release Bryce Baringer? Mike Vrabel explains.

Baringer was released after three seasons as the Patriots’ punter.

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Oct 26 • 7:07 PM EDT • Sports • sports.yahoo.com
Matthew Perry’s sister explains how his addiction struggles inspired her career as a psychotherapist

Matthew Perry’s sister, Mia Perry Bowick, explained how the ‘Friends’ star’s substance use disorder impacted her decision to become a psychotherapist.

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Oct 26 • 5:48 PM EDT • Entertainment • ew.com
New Jersey Cannot Prescribe Better Health Without Making Healthy Food Accessible

By Assemblyman Kenyatta Stewart We tell people with diabetes to watch their blood sugar. We tell people with hypertension to reduce their sodium. We tell families to eat more fruits and vegetables to prevent chronic disease. But what happens when the food we recommend is beyond their budget or unavailable in their neighborhood? That is[...]

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Oct 26 • 5:20 PM EDT • Health • insidernj.com
Billy Evans suggested the shower scene in 'You Can See Everything'

"You Can See Everything" director Lance Oppenheim said that Elizabeth Holmes' partner, Billy Evans, suggested he be filmed in the shower.

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Oct 26 • 4:53 PM EDT • Business • businessinsider.com
Brackets: Section 1 football postseason results, schedule, scores

Action begins this week.

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Oct 26 • 4:42 PM EDT • Sports • sports.yahoo.com
Alan Dysert, “All My Children” star, dies at 75 after being diagnosed with ‘incurable cancer’

The actor discussed his condition in his 2023 book “Lights, Camera, Cancer.”

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Oct 26 • 3:48 PM EDT • Entertainment • yahoo.com
Heidi Klum, Queen of Halloween, teases this year’s ‘bloody’ costume

Each year, Klum unveils her full costume at her star-studded costume party on Oct. 31 in New York City.

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Oct 26 • 1:57 PM EDT • Entertainment • yahoo.com
Brewers' Garrett Mitchell talks about watching his health to manage diabetes

Milwaukee Brewers center fielder Garrett Mitchell talks about watching his health to manage his diabetes.

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Oct 26 • 1:14 PM EDT • Health • sports.yahoo.com
Brewers' Garrett Mitchell talks about watching his health to manage diabetes
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Oct 26 • 1:14 PM EDT • Health • jsonline.com
Why Bexar County's DA candidates are avoiding partisan politics

DA candidates Luz Elena Chapa, Ashley Foster and Jason Wolff say party labels don’t define them. Their plans for the felony backlog and diversion show where they differ.

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Oct 26 • 12:40 PM EDT • Politics • expressnews.com
Conte breaks silence amidst reports he could return to Juventus

Several reports have linked Antonio Conte with a return to Juventus and a possible move to Manchester United, with both clubs reportedly considering changes in the dugout. Conte continues to be associ...

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Oct 26 • 11:05 AM EDT • Sports • sports.yahoo.com
6 citizens sue Trump, saying media ban deprives them of news as audience stakeholders

A new lawsuit against President Donald Trump's media ban stakes a claim for the public itself.

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Oct 26 • 10:49 AM EDT • Politics • ksat.com
Ian-credible Science: DNA extraction with Dr. Elizabeth Racz-Brunner

Each week, we bring you a quick and easy experiment you can do at home to explore a concept in science. This week, we’re on the road at South Dakota Mines to learn about DNA extraction.

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Oct 26 • 8:14 AM EDT • Science • kotatv.com
Inside Business 2026 Top Forty Under 40: Carley McClintock, Elizabeth River Crossings

Carley McClintock works in communications and community relations at Elizabeth River Crossings.

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Oct 26 • 7:38 AM EDT • Business • pilotonline.com
Mike Vrabel is not concerned about A.J. Brown: ‘Just have to get back into a rhythm’

| WEEI 93.7

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Oct 26 • 7:33 AM EDT • Sports • audacy.com
In his own words: Trump on gas prices and energy costs since launching the war with Iran

Since launching the war with Iran nearly eight months ago, U.S. President Donald Trump has struggled to quell soaring energy costs, undermining Republicans’ attempt to keep control of Congress in the midterm elections next week.

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Oct 26 • 6:25 AM EDT • Politics • ksat.com
Did Elizabeth Holmes and Billy Evans get paid for their documentary?

Nathan Fielder’s documentary turns a dispute over paying its subjects into a central source of tension. Here’s what we know about the proposed deal.

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Oct 26 • 6:00 AM EDT • Entertainment • latimes.com
How to Manage Symptoms of Heart Failure

(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });

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Oct 26 • 1:00 AM EDT • Health • journalgazette.net
Patrick Mahomes Earns New Nickname From Kansas City Chiefs
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Oct 26 • 12:14 AM EDT • Sports • sports.yahoo.com
Groundskeepers at prepare the bullpen mounds at Tropicana Field

Groundskeepers prepare the bullpen mounds at Tropicana Field in preparation for the World Series in St. Petersburg, Florida.

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Oct 25 • 11:01 PM EDT • Sports • sports.yahoo.com
Has Taylor Moton played final NFL game with Panthers?

Carolina's veteran right guard fractured his fibula on Sunday, leaving his NFL future in doubt.

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Oct 25 • 10:40 PM EDT • Sports • sports.yahoo.com
Georgia lands son of music star in notable recruitment win

Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.

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Oct 25 • 9:26 PM EDT • Sports • sports.yahoo.com
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Kyle Larson’s Championship Moment Comes at Talladega

Conquering his drafting-track demons, Larson surged from mid-pack chaos to secure a historic Hendrick 1-2 finish, building a massive points cushion that places the title within reach

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Oct 25 • 7:08 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Shia LaBeouf waged one-sided feud with Hilary Duff, says “Even Stevens” costar

Duff’s own Disney Channel series, “Lizzie McGuire,” was one of the Disney Channel’s defining hits of the 2000s.

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Oct 25 • 6:22 PM EDT • Entertainment • yahoo.com
Shia LaBeouf waged one-sided feud with Hilary Duff, says ‘Even Stevens’ costar

Christy Carlson Romano says her ‘Even Stevens’ costar, Shia LaBeouf, was ‘beefing’ with Hilary Duff during their overlapping Disney Channel days: ‘He had to be the number one.’

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Oct 25 • 6:22 PM EDT • Entertainment • ew.com
2026's First $1 Billion Movie Finally Confirms Netflix Release Date
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Oct 25 • 4:34 PM EDT • Entertainment • yahoo.com
Ravens surrender 35 unanswered points in stunning loss to Bengals

Baltimore squandered a 13-0 halftime lead as Joe Burrow threw four touchdown passes and Cincinnati handed the Ravens a 35-13 defeat

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Oct 25 • 4:33 PM EDT • Sports • sports.yahoo.com
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Four receptions for Chris Godwin Jr.

Buccaneers WR Chris Godwin Jr. leads team with four receptions in Week 7 win

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Oct 25 • 4:31 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Michigan basketball gets reality check in exhibition loss vs Houston

Michigan writer Tony Garcia offers three observations from the Wolverines' 83-66 loss to Houston in its final exhibition.

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Oct 25 • 3:42 PM EDT • Sports • sports.yahoo.com
Elizabeth Holmes film puts up a fight against 'Clayface' at box office

A movie set in the world of Batman and a three-hour documentary about Elizabeth Holmes went head-to-head at the box office this weekend, and it turned out to be a closer contest than expected.

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Oct 25 • 2:50 PM EDT • Entertainment • bellinghamherald.com
Elizabeth Holmes film puts up a fight against 'Clayface' at box office

A movie set in the world of Batman and a three-hour documentary about Elizabeth Holmes went head-to-head at the box office this weekend, and it turned out to be a closer contest than expected.

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Oct 25 • 2:50 PM EDT • Entertainment • sacbee.com
Freddy Peralta was beloved in Milwaukee. Now he stands in Brewers’ World Series path
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Oct 25 • 2:48 PM EDT • Sports • sports.yahoo.com
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells

Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...

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Oct 25 • 1:19 PM EDT • Science • yahoo.com
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1

NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...

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Oct 25 • 1:16 PM EDT • Entertainment • usnews.com
3 Cubs Who Will Decline Their Options
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Oct 25 • 1:01 PM EDT • Sports • sports.yahoo.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.

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Oct 25 • 12:49 PM EDT • Politics • ksat.com
Clayface Takes First Place While Holmes Documentary Grows in Week Two

Clayface opened with $24.5M, while A24's three-hour Elizabeth Holmes documentary You Can See Everything grew 25% in its second weekend.

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Oct 25 • 12:47 PM EDT • Entertainment • northeasttimes.com
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”

Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.

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Oct 25 • 12:31 PM EDT • Technology • notebookcheck.net
Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
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Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation

Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...

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Oct 25 • 11:49 AM EDT • Science • yahoo.com
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes

Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.

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Oct 25 • 11:34 AM EDT • Entertainment • thenewstribune.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
MCHD: Several people treated at local emergency rooms for bat bites in Baldwin County

The Mobile County Health Department says the patients were bitten at different residences in Baldwin County.

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Oct 25 • 11:00 AM EDT • Health • fox10tv.com
"I mean, stuff happens. It's a business. It's not in …

"I mean, stuff happens. It's a business. It's not in …

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Oct 25 • 9:57 AM EDT • Sports • sports.yahoo.com
"I mean, stuff happens. It's a business. It's not in …

"I mean, stuff happens. It's a business. It's not in …

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Oct 25 • 9:57 AM EDT • Business • sports.yahoo.com
Investment driving growth at NWS Crane

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Oct 25 • 9:53 AM EDT • Business • insideindianabusiness.com
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Iowa Football Was Never Truly A CFP-Caliber Team. The Loss To Minnesota Proved It

The Hawkeyes had plenty of momentum after the Washington game, but there's just too much inconsistency right now. Everything fell apart against Minnesota.

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Oct 25 • 9:00 AM EDT • Sports • sports.yahoo.com
She voted for Trump every time. Then came cancer and the bills

Cindy Banda faces mounting medical bills after battling breast cancer.

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Oct 25 • 8:34 AM EDT • Politics • ksat.com
Memorial Health dietitian highlights importance of blood sugar management

Zeff encourages people to schedule regular medical appointments and get their blood sugar tested, particularly those with a family history of diabetes.

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Oct 25 • 7:59 AM EDT • Health • capitolcitynow.com
Unwanted endorsement: Political ad causes uproar at Jerusalem's Lev Academic Center

Those who know the highly regarded college, which since 1969 has produced religious graduates with degrees in a variety of engineering fields and nursing, were likely surprised. Thousands of drivers a...

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Oct 25 • 3:52 AM EDT • Politics • yahoo.com
These Milwaukee Brewers are two games from immortality in World Series
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Oct 25 • 2:52 AM EDT • Sports • sports.yahoo.com
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1 player Eagles must target at 2026 NFL trade deadline

If the Philadelphia Eagles make any more trades before the 2026 trade deadline , it should almost certainly be as sellers, not buyers. Now sure, could Roseman find a bargain on the margins and make a move, like if a team is willing to take a conditional seventh-round pick for a player at a position of need – safety, anyone? -instead of releasing […] The post 1 player Eagles must target at 2026 NFL trade deadline appeared first on ClutchPoints.

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Oct 24 • 11:53 PM EDT • Sports • sports.yahoo.com
Mission Health hospitals collect 289 pounds in 'Crush the Crisis' drug take-back day

One simple step. For some local hospitals - that makes a big difference in keeping dangerous medications out of the wrong hands.

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Oct 24 • 10:05 PM EDT • Health • wlos.com
Cincinnati Reds Made Massive Mistake With Ke’Bryan Hayes

The Cincinnati Reds made a massive mistake acquiring infielder Ke'Bryan Hayes.

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Oct 24 • 8:47 PM EDT • Sports • sports.yahoo.com
Sullivan, Peltola seek support from Alaska Native voters ahead of crucial Senate race

The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election.

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Oct 24 • 8:07 PM EDT • Politics • ksat.com
Giants should send Malik Nabers at Houston’s weakened middle

Houston will be without safeties Reed Blankenship and Jalen Pitre on Sunday. I’d make those absences part of the Giants‘ […]

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Oct 24 • 7:05 PM EDT • Sports • sports.yahoo.com
Ravens QB Lamar Jackson Downgraded to OUT for Bengals Game

Baltimore Ravens quarterback Lamar Jackson has been downgraded to OUT for the Bengals game.

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Oct 24 • 3:48 PM EDT • Sports • sports.yahoo.com
Without tight end Cole Kmet, Bears may run more jumbo six-lineman formations
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Oct 24 • 12:30 PM EDT • Sports • sports.yahoo.com
3 Way-Too-Early Pittsburgh Pirates Offseason Predictions

Will the Pittsburgh Pirates continue to be aggressive this offseason?

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Oct 24 • 12:00 PM EDT • Sports • sports.yahoo.com
Brian Thomas Jr. could be on the move

Jaguars WR Brian Thomas Jr. is believed to be a trade candidate leading up to deadline

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Oct 24 • 11:08 AM EDT • Sports • sports.yahoo.com
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Stock Market Action Plan: A Preelection Week Primer

The stock market faces a heavy week of earnings from the likes of Alphabet and Amazon, along with a Fed meeting and preelection positioning.

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Oct 24 • 10:28 AM EDT • Business • investors.com
Michigan State Starting QB Out Against No. 9 UCLA

With both teams forced to start inexperienced backups, true freshman Kayd Coffman makes his first career start as the battered Spartans seek a Rose Bowl miracle.

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Oct 24 • 9:45 AM EDT • Sports • sports.yahoo.com
‘Wicker’ stars explain why women are ‘going slightly feral’ over Alexander Skarsgård’s character

‘Wicker’ stars Olivia Colman, Elizabeth Debicki explain why women are ‘going slightly feral’ over Alexander Skarsgård’s character in their new movie.

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Oct 24 • 9:30 AM EDT • Entertainment • ew.com
Broncos vs. Cardinals score predictions for Week 7

The Denver Broncos have what we all would have marked down as an “easy” type game in May, but after they slogged through the first six weeks against some of the NFL’s best teams it doesn’t feel like there are any easy games at this level. The Arizona Cardinals are also coming off a huge […]

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Oct 24 • 9:00 AM EDT • Sports • sports.yahoo.com