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Thousands of observers from the right and left will descend on polling places to monitor the vote on Election Day
The effort among Democratic and nonprofit groups includes training volunteers to stand watch outside polling places and report activities they consider concerning.
Better targeted actions needed to tackle unequal impacts of noise pollution for vulnerable groups
Noise pollution affects us all, but some populations like children, older adults and people with pre-existing health conditions may suffer more health wise due to excessive transport noise according to a European Environment Agency (EEA) briefing released today. The analysis recommends better targeted actions to protect vulnerable and disproportionately exposed populations.
Women’s Heart Health Care Starts at Puberty: New Shared Framework from Leading Medical Societies
The American Heart Association, American Academy of Pediatrics, American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine released landmark publications that redefine women’s heart health, starting at puberty. Amanda Marma Perak, MD, MSCI, a pediatric cardiologist at Ann & Robert H. Lurie Children’s Hospital of Chicago was the Vice-Chair of the collaborative writing group.
Small-business owner shares lessons on passion, research & earning customer trust
Cantrece Jones founded Acuity Design Group in 2008 and opened Aura Plant Studio more than four years ago. She said the businesses have grown gradually, with the plant shop expanding into commercial installations and event rentals as well as retail.
AND2BLE takes its next step with 'French Kissing' at comeback showcase in Seoul
The five-member group explores how curiosity turns into irresistible attraction in its second EP 'Sequence 02: Attraction.'
Orthopedic Surgeon Gary N. Ackerman, MD, Joins Palm Beach Health Network Physician Group - Florida Hospital News and Healthcare Report
October 22, 2026 – Orthopedic surgeon Gary N. Ackerman, MD, joins the Palm Beach Health Network Physician Group. He is on staff at Palm Beach Gardens Medical Center. Dr. Ackerman […]
Syngenta Earns Science's Top Ag-Employer Honors for 10th Straight Year
Science magazine's annual Top Employers survey has ranked Syngenta Group as agriculture's leading employer for the 10th straight year.
Simple Town Sketch Group Secures North American Deal For Debut Feature ‘Big Break’
EXCLUSIVE: Greenwich Entertainment has acquired North American rights to Big Break, a comedic thriller marking the debut feature of New York-based sketch comedy group Simple Town. They’ll release the ...
Rice engineering students become first university group inside Apple’s new Advanced Manufacturing Center
Rice University materials science and nanoengineering students gained hands-on experience in AI server production and surface-mount technology during an exclusive tour of Apple’s new Advanced Manufacturing Center in Houston.
As the US and China form AI blocs, countries are increasingly torn between them
With the two leading AI powers, the United States and China, forming their own AI blocs, other countries are maneuvering to harness the strengths of both groupings without alienating either and risking losing out.
READERS' CHOICE | Impact Realty Group makes its mark with Best Small Business win
A locally owned and operated real estate brokerage has been named Best Small Business in the 2026 Texarkana Gazette Readers' Choice Awards.
Good Sports: Clovis West champion Ryleigh Schoonover begins Fresno State journey
As another group of standout players from Clovis West girls' basketball moved on, Ryleigh Schoonover chose to stay close to home to play for Fresno State.
Oakland Coliseum hopes to become new sports, entertainment hub
(KRON) — The people working to purchase the Oakland Coliseum site say they are on track to close the deal before the end of the year. The African American Sports and Entertainment Group, alon…
N.C. Residents Inundated with Mailers Urging Them to Vote. Here's What to Know.
A group has flooded mailboxes encouraging North Carolinians to cast a ballot, including some who already have.
Denver Health Medical Plan Discloses Vendor Breach Affecting 238K Members
Denver Health Medical Plan has notified more than 238,000 individuals about a vendor-related data incident. Data breaches have also been announced by Denver Health Medical Plan has notified more than 238,000 individuals about a vendor-related data incident. Data breaches have also been announced by Johns Hopkins Bayview Medical Center and BASS Medical Group.
Mbappé: “This was a team win”
Real Madrid star Kylian Mbappé talked to Real MadridTV after Los Blancos conquered the Camp Nou with a 1-2 victory where he scored both of the team’s goals. “It is a team victory. The protagonist of the match is the team and the group because we knew we had to play a strong game, but […]
CIDRAP Director Michael Osterholm recognized for defending vaccine science
But the University of Minnesota epidemiologist says the recognition belongs to a much larger group.
Rodeo Cruelty Is Not Entertainment — Expedia Must Stop Selling Tickets!
Rodeos torture animals, inflicting terror, pain, injury, and sometimes death. Expedia must follow TripAdvisor: stop selling rodeo tickets.
The real rebels of rock are those who ignore politics
Rockers once proved their "rebel" credentials by trashing hotel rooms, scuffling with bandmates or having their way with as many groupies as possible. Sometimes all three.
Podiatrist Juan E. Sardiña, DPM, Joins Palm Beach Health Network Physician Group - Florida Hospital News and Healthcare Report
October 22, 2026 – Podiatrist Juan E. Sardiña, DPM, has joined Palm Beach Health Network Physician Group. Dr. Sardiña is on staff at Palm Beach Gardens Medical Center. Dr. Sardiña […]
Empath Health expands dementia support services for Suncoast families
Empath Health is expanding its dementia services across the Suncoast, offering families and caregivers access to education, support groups, Memory Cafés and other resources to help navigate a dementia diagnosis.
TWICE's Nayeon to make solo comeback with 'NA-sty' on Nov. 20
Na-yeon of K-pop girl group TWICE will release her new solo project, “NA-sty,” on Nov. 20, marking her first solo comeback in about two years and f...
IPS school board candidates raise over $150,000 from political action groups
Political action committees for education groups gave over $150,000 to candidates seeking one of five spots on the Indianapolis Public schools board.
Bravo casts controversial ‘Big Brother’ star Aaryn Williams on Texas-based reality show
The new reality show ‘Small Town Trouble: Texas’ is set to follow a group of women living in Boerne, Texas, including controversial ’Big Brother’ alum Aaryn Williams, who was known as Aaryn Gries during season 15 of the CBS show.
CopperPoint completes $84 million General Indemnity Group deal to build national surety business
The Arizona workers’ comp specialist now owns a surety carrier and a digital bond platform licensed in all 50 states, and says it is adding capital to grow the business.
2026 Business Insurance Best Places to Work
Best Places to Work in Insurance is an annual feature presented by Business Insurance and Best Companies Group that ranks the agents, brokers, insurers and other providers with the highest levels of…
Umios to acquire High Liner Foods to expand North American seafood business
High Liner Foods has agreed to be acquired by Japanese seafood group Umios in a deal aimed at strengthening the companies’ positions in North American seafood.
Group says biology-based sports amendment advances in MSHSL process
Regional votes would have to be complete by Feb. 15.
British politicians among international delegates barred from entering West Bank
Group was on visit to meet Palestinian children, farmers and civil leaders facing escalating violence from Israeli forces
JYP Entertainment shares rally on report of tender offer to buy up to 50% stake
South Korean pop music agency JYP Entertainment's KRX:035900 shares rallied on Tuesday, jumping 10% after Korean media reported Japan's Nexroc Group and SVCV Inc were planning to announce a tender offer to buy up to a 50% stake in the company.The 50% stake is worth about 700 billion won ($528.04 mi…
SLC, SEG Still Negotiating Key Details Over Future of Entertainment District
Two years after the City Council told Smith Entertainment Group it would have to earn staff-level design review, the company's draft agreement for the Downtown district asks for it, and for much more.
Scientists Map Research Priorities for U.S. Climate Assessments
A group of 175 scientists co-led by a Rutgers University professor have developed a research framework identifying gaps in the evidence needed to assess coastal protection, food production and overlapping climate hazards such as extreme heat and power outages.
Economy, 'political homelessness' is top of mind for Ohio voters
Morning Edition Host Amy Eddings is back with another installment of the Ideastream election series that interviews voters from the Mahoning Valley ahead of the midterms.
IPS school board candidates raise over $150,000 from political action groups
In total, the candidates raised more than $257,000 with about 22% coming from individual contributions.
Lee Health Foundation Announces Board of Trustees - Florida Hospital News and Healthcare Report
Oct. 23, 2026 – Lee Health Foundation has announced its 2027 Board of Trustees, a distinguished group of community leaders, healthcare advocates, and business professionals dedicated to advancing philanthropy and expanding […]
JYP Entertainment soars 10% on reports of tender offer plan to buy up to half of firm
South Korean pop music agency JYP Entertainment's KRX:035900 shares jumped 10% on Tuesday after Korean media reported Japan's Nexroc Group and related firm SVCV Inc were planning to announce a tender offer to buy up to a 50% stake in the company.The 50% stake is worth about 700 billion won ($528.04…
Poll: Low-information voters have turned hardest against Trump and the GOP
In 2024, the voters who knew the least about politics were some of Donald Trump’s strongest supporters. A Data for Progress poll released just before the election found Americans who didn’t consume any news at all said they’d vote for Trump over Kamala Harris by a 20-point margin, 60%1 to 40%. In February, we reported that many of these voters had soured on Trump. Voters who couldn’t name the party in control of Congress moved away from Trump at about twice the rate as high-information voters. But approval isn’t vote choice. With the midterms less than two weeks away, it is worth asking if these voters are turning against the president’s party in federal elections, too. In our October Strength In Numbers/Verasight poll, conducted Oct. 13–19 among 2,028 U.S. adults, we asked respondents two factual questions about politics: which party has the most members in the House, and which has the most members in the Senate. I classified anyone who got at least one of these questions wrong as “low-knowledge.” About 30% of adults miss at least one question, including 25% of 2024 Trump voters, 22% of Harris voters, and more than half of people who didn’t vote in 2024. In this article, I do two things with this data. First, I repeat my February analysis and compare how these two groups feel about Trump’s job as president; then I look at each group’s voting behavior in the upcoming House midterms. Register for free to read the rest of this piece.
‘Dream big’: The Seattle-area kids and teens launching businesses
Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.
In Texas Senate Race, Talarico Leans Into Growing Rivalry With Elon Musk
On the trail, James Talarico, the Democratic Senate nominee, has increasingly gone after Mr. Musk, a critic of his who has given big to a group aligned with the Republican candidate, Ken Paxton.
The Fans Trying To Save Mass Effect Just Paid For A Billboard In Times Square
The group’s petition to keep BioWare’s series alive just surpassed 200,000 signatures
The Texas trans advocacy texts and mailers were fake. Their impact is real, and hard to control
Texts and pamphlets purportedly sent out by a Texas transgender advocacy group were soon debunked as fake. But the scheme highlights how hard it can be to stem the flow of incessant political marketing during election season — and to reverse its harmful effects.
To fix Michigan schools, experts urge better reading skills, less politics
A group of education experts urged audience members at the Bridge Michigan Issues Summit to volunteer in schools, vote for candidates who value education and set aside individual differences to work toward a common plan to improve schools.
Business Buzz
According to the Home Legacy Group at Coldwell Banker, 60 homes sold during September.
Coyer Candle Co. nears $1 million raised for community groups
Coyer Candle Co., owned by Scott and Lisa Coyer, produces clean-burning candles with 100% soy wax and cotton wicks.
EQS Group receives validation of its climate targets by the Science Based Targets initiative
EQS Group, a global leader in agentic AI SaaS for compliance, today announced that the Science Based Targets initiative (SBTi) has successfully validated EQS Group's near-term and net-zero greenhouse gas (GHG) emissions reduction targets.
New directorships provide crucial support for Vanderbilt Health’s missions
The most recent Vanderbilt Health directorships are spread throughout many departments — highlighting individuals who make an impact in myriad ways.
115-year-old Pan-American Life Insurance Group on track to surpass $2B in revenue
Insurance industry veteran José Suquet's bags were nearly packed for a job in Miami in 2004 when recruiters looking to fill the top job at Pan-American Life Insurance Group in
Japanese Group Targets 50% Stake in JYP Entertainment
Japanese Group Targets 50% Stake in JYP Entertainment NEXROC and SVCV plan 30% premium tender; JYP denies receiving acquisition proposal
A doctor traded health insurance for direct primary care, cost-sharing
A doctor explains why he replaced traditional health insurance for his family of four with direct primary care and a medical cost-sharing group.
Climate group pours in midterms money for Democrats
The League of Conservation announced more than $100 million to support Democrats going into the midterms.
With Midwestern baseball at its core, Delaware North wins Royals’ new ballpark F&B business
The Royals have selected Delaware North Sportservice as the food and beverage provider at the MLB team’s new ballpark that opens in 2030.
Orthopedic Surgeon John Randazzo, MD, Joins Palm Beach Health Network Physician Group - Florida Hospital News and Healthcare Report
October 22, 2026 – Orthopedic surgeon John Randazzo, MD, has joined Palm Beach Health Network Physician Group. He is on staff at Palm Beach Gardens Medical Center. Dr. Randazzo specializes […]
Groundbreaking Guidelines Released for Women’s Heart Health
The guidelines, which were authored by four major medical groups, are a framework for how hormonal changes up heart disease risk from puberty to after menopause.
Rhode Island FC hires Lou DePaoli as president of business operations
DePaoli said he intends to prioritize making Centreville Bank Stadium, which currently operates about 50 dates annually, a year-round entertainment destination.
Dover schools expand mental health support, plan healing forums
Dover City Schools plans to hold small-group forums for families as the district focuses on safety, support and long-term healing after what Superintendent Karie McCrate described as six weeks of "overwhelming loss."
Who's In Charge? The Faces Of Serbia's Student-Backed Political Movement
The Students' List, a political grouping of 250 representatives that just won Serbia’s parliamentary elections, has deliberately avoided having a clear leader. While it remains uncertain who Serbia’s prime minister will be, here are some of the high-profile Serbians representing the movement.
Scary Business Trick or Treat set for Sunday in Crestline
CRESTLINE – The Crestline Community Development Team (CCDT) is hosting Scary Business Trick or Treat from 4 to 5 p.m. Sunday, Oct. 25 in downtown Crestline. The costume contest will take place at 5:15 p.m. on the patio at The Hub. Contest age groups are 0-2, 3-5, 6-10, 11-13, and family/group. “Downtown is always full […]
Simple Town Movie 'Big Break' Lands North American Deal With Greenwich
Comedy group Simple Town's feature 'Big Break' has landed a North American distribution deal with Greenwich Entertainment. It'll release next year.
TWICE's Jihyo Announces Departure from JYP Entertainment
The group's leader is the third member to end her individual contract with JYP while staying in TWICE.
2026-27 Mizzou Men’s Basketball Preview: Wings
A senior and a freshman bring varying experience, similar skillsets to position group
Workforce Solutions Jobs Update, 10-26-26
Texas Border Business Below you will find our Hot Jobs for this week, all these jobs and many more are available on www.workintexas.com. U.S. Border Patrol Information Session Tuesday, October 27, 2026 9 am – 12 pm Workforce Solutions Mission 901 Travis St., Ste.7 Mission, TX 78572 https://www.facebook.com/share/1CACWSYGJW Kumori Group Hiring Event Tuesday, October 27, 2026 […]
Americans for Prosperity dropped its support for Martina White and other GOP lawmakers over their prevailing-wage vote
The right-leaning group has pulled its endorsements at a time when Republicans in swing districts may need all the help they can get.
Blue Frog founder John Campbell named group CEO of Avidly
Avidly, a global technology services company specializing in customer relationship management and go-to-market solutions, appointed Blue Frog Founder John Campbell as group CEO, effective Oct. 7. Campbell leads the company, which has nearly 300 employees across nine countries, from its North American offices in Waukee. He will continue serving as CEO of Blue Frog. Campbell…
JYP Entertainment Jumped On Talk Of A 50% Tender Offer
Reports said Japan’s Nexroc Group and SVCV could target 25%-50% of the K-pop agency at a roughly 30% premium, even as JYP said it hasn’t received an offer.
Japanese investment group claims JYP takeover, raising questions over credibility
An obscure investment group claiming to be based in Japan sparked controversy in the K-pop industry Monday by announcing plans to acquire a controlling stake in
Mark Walter borrowed from Chicago firm with investigators circling
Amistad Financial Group, a holding company that counts Magic Johnson as a minority owner, loaned about $1.26 billion to Walter’s companies between March and June of this year.
RJW Logistics to open second Northwest Arkansas office
Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...
A tiny defect in a crystal reveals a big quantum surprise
Researchers have solved a long-standing challenge in understanding how tiny defects in materials like diamond and silicon carbide behave when exposed to light. Their new computational method revealed a surprisingly important energy-loss mechanism in silicon carbide that scientists had previously underestimated. The finding helps explain a mystery that has puzzled researchers for years and could improve the design of quantum computers and sensors.
Google Messages is working to finally clean up its messy settings menu
Between organizing options into groups and adding some useful illustrations, Google Messages is working on major changes to settings.
There’s a Reason That Netflix’s Ad Business Has Underwhelmed
Somewhat lost in the company’s slew of firings and engagement warnings over the past few weeks was the fact that Netflix is scaling back its ad forecast for 2026 from $3 billion to $2.7 billion. That’s despite the fact that: CTV is growing by 14-15% this year This year saw a monster upfront Netflix is the biggest streamer out there this side of YouTube, and was the platform that for years brands were supposedly dying to be a part of In other words, that’s an alarming pull-back from Netflix. A Wall Street analyst I spoke with last week was blunt, calling Netflix’s ad business “disappointing.” To me, a red flag on the ad front is that Netflix has never revealed how many ad-supported subscribers it has. Because if I know anything about how big companies work, if they have a positive number that makes them look really good - they tend to share it. (How many subs does go90 have right now? We’re not saying just yet. How are ads going on ChatGPT? Oh, a billion run rate - I see). Yes, to date Netflix has shared some fuzzy ad numbers, such as the idea that the company’s ad tier ‘reaches’ 250 million users globally.’ Here’s why that figure gives me pause: a)they lead with global, and b) they don’t explain how they are calculated. (Are they based on average people in each room? Surveys of some kind?). Regardless, some insiders say that Netflix’s ad tier is scaling nicely - others not so much. Either way, one of Netflix’s biggest challenge on the ad front appears to have been its starting point. Remember, when Netflix launched ads in 2022, it had 73 million subs in the US and Canada. That’s 73 million people who were used to Netflix with zero ads. And when the ad product rolled out, the company clearly was going after new users - a limited pool of potential subscribers by default. That focus seems to have changed over time, as Netflix has tried to convert longtime subscribers to the ad tier. Historically Netflix subscribers are very sticky. But is the company’s low churn a problem? Not necessarily, according to Antenna data. Rather, Netflix’s consumer loyalty is a bit of a double-edged sword. “Netflix is the one streamer which actually has seen substantial “trade downs” but has much lower ‘win backs,’ said Antenna founder Jonathan Carson (win-backs being people who were on the ad-free plan, cancelled, then rejoined on the ad plan). “Netflix has lower churn and so has less opportunity to win back old subs with a lower cost plan option.” This all might explain why Netflix has been so slow to roll out all of these table stakes targeting options until just this week. It likely didn’t have enough users to carve up into various targets. etc. However, what really hit Netflix’s ad business was Amazon’s move a few years ago to turn on advertising for Prime Video by default. Suddenly the market was awash in premium inventory, and Netflix was playing catch-up on multiple fronts. Thus, the streaming giant appears to still be figuring out if if wants lead in ‘programmatic TV,’ or premium ‘upfront’ TV sales. “The CTV market now sorts into three businesses, and Netflix is not the leader of any of them,” wrote analyst Jack Myers. Ouch. So how does Netflix ratchet up its ads business? Get the next NFL package You’re gonna have to wait until 2030 unless one of the bigger media companies like Skydance opts out, but the easiest (not cheapest) way for Netflix to become a huge TV ads contender is to get one of the regular NFL packages, ideally Sunday afternoons. That way it can sell ads to its whole U.S. subs base overnight. Go FAST This one is risky, because to program a compelling FAST channel, you’d likely have to take some older Netflix exclusive shows and make them available for free to non-subscribers. But FASTs, for better or worse, are ad-inventory machines. Go full UGC I’m not sure I see this happening. There is something already off about Netflix carrying podcasts and shows for creators. The experience sticks out in what is such a produced, and generally non-communal environment. But Netflix could open up its platform by allowing creators to upload videos without having to be approved by the service. But that opens a whole other can of worms (policing brand safety, copyright infringement, overall quality). Make a huge RMN Deal I was going to suggest something crazy, such as ‘instead of buying Warner Brothers, Netflix should buy Target. But the company doesn’t want to be in the brick and mortar business. Yet for Netflix’s ad business to compete in an Amazon world, it needs to be able to connect ad exposures to shopping. What if, instead of letting Amazon target Netflix viewers with its DSP, Netflix inked a deal with Target, or even took control of Roundel, and created its version of the Amazon full-funnel for brands? Price us out. I hope they don’t do this, but Netflix’s price increases - while significant - haven’t been enough to push long-term customers out of the ad-free tier. But if they made those prices so prohibitive, it could push large swaths of consumers to trade down. Then again, that could also dent engagement - as binging becomes much less appealing once you bring ads into the equation. Or, they could just launch a bunch of hit shows and maybe everyone will quickly forget all this angst. More from Amazon unBoxed A few weeks ago, I recorded two podcasts live at Amazon’s unBoxed event in San Francisco. I was able to go really deep with several brand partners about how Amazon’s various data and ad products work - particularly the under appreciated Amazon Marketing Cloud. First, I talked with Laura Abadias Velilla, of the Amazon specialty agency Amerge, along with Amazon’s own Charlotte Maines, Vice President, Devices Content & Advertising, about how the two partners helped a very specific printer company Epson launch into a brand new category - high end projectors. It’s a great example of how brands connect audience data across platforms to make budget deployment decisions. Next, I chatted with Monks VP Head of Digital Investment for North America Tom Burchill about how the agency actually brought in data from Linkedin to help target B2B customers across various Amazon properties for the brand Quicken. Check it out: Check these out, or just listen:
Liberty Mutual Re and Celest.Science explore parametric trigger data fallback
Liberty Mutual Reinsurance (LM Re) part of Liberty Mutual Insurance Group, and Celest.Science have announced a collaboration to explore the development of
Safran To Divest Cabin Business
Safran launches the sale of its $2.24 billion cabin business as the French aerospace group sheds its aircraft interiors unit.
Star Entertainment returns to positive earnings and cash flow in first quarter
Star Entertainment Group has returned to positive earnings and operating cash flow for the first time in more than two years, helped by stronger revenue across its casino and resort portfolio and lower corporate costs. Ahead of its annual general meeting in Sydney, the casino operator...
Star Entertainment Group Posts Q1 FY27 Group EBITDA A$12 Million
The Star Entertainment Group Limited ASX:SGR:
Q+A: How this private equity group raised $1.3 billion investing in fr
Doug Kennealey, co-founder of Princeton Equity Group, said franchises are "phenomenal" and "cash-rich" business models. The firm secured $1.3 billion in two months for its most recent fund.
Focus groups: Their candidates lost in the Michigan and Texas primaries. Now what?
Senate candidates Abdul El-Sayed in Michigan and Ken Paxton in Texas are looking to convince backers of their primary opponents to support their campaigns.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Week 9 Nebraska volleyball grades
Nebraska volleyball is still undefeated after taking down USC and No. 18 UCLA. Bergen Reilly, Harper Murray and Virginia Adriano each put up impressive performances for the Huskers. Sports reporter Danny Berg grades the performance of each position group in those victories.
JYP Entertainment shares rally on report of tender offer to buy up to 50% stake
South Korean pop music agency JYP Entertainment KRX:035900 shares rallied on Tuesday, jumping 10% after Korean media reported Japan's Nexroc Group and SVCV Inc were planning to announce a tender offer to buy up to a 50% stake in the company.
Friend Development Group highlights new businesses, local revitalization
Friend Development Group, Inc., is seeing new businesses and economic growth in Friend, and there are a number of shopping opportunities downtown.
Missouri Doesn't Need More Marijuana Business Licenses, State Study Says, But Questions Remain About Ownership Concentration
“Ownership-based analyses would provide a more comprehensive assessment of market structure by evaluating concentration across common ownership groups.” By Rebecca Rivas, Missouri Independent Missouri regulators say the state doesn’t need to issue more licenses to grow, manufacture or sell marijuana because the legal cannabis market is meeting consumer demand. But the statewide study behind that conclusion couldn’t […]
ACHI’S Sarah Crawford Named to AcademyHealth Advisory Panel on Oral Health
Sarah Crawford, ACHI’s assistant director of analytics, has been selected by AcademyHealth to serve on its Oral Health Interest Group Advisory Committee.
Pokemon UNITE to end service on March 23, 2027
The Pokemon Company and developer TiMi Studio Group will end service for free-to-play multiplayer online battle arena game Pokemon UNITE on March 23, 2027, the companies announced.
Punahou Alumni Healthcare Spotlight Connects Students with Industry Professionals
Punahou hosted its 11th annual Alumni Healthcare Spotlight on October 14, bringing together alumni healthcare professionals and current students. A student committee helped plan the event over the last several months. The evening kicked off with a keynote address in Cornuelle Hall by Dr. Sam Shomaker, dean of the John A. Burns School of Medicine (JABSOM) at University of Hawai’i. He was introduced by Punahou trustee Dr. Doug Kwock ’83. Student attendees then pivoted to small-group breakout sessions, where they […]
VIDEO: Tommy Lloyd says don't let politics 'impact these kids' seeking five-for-five eligibility
During a small-group interview at Big 12 media days, UA coach Tommy Lloyd explained why he believed the NCAA should issue a blanket waiver for athletes who graduated high school
Reckitt cuts sales outlook as Lysol and China businesses hit
Group’s European business returned to growth despite ‘challenging’ consumer environment and lower cold and flu incidence
Star Gazing: Inside ESSENCE’s 2026 Black Women In Business Celebration
Sponsored by L’Oréal Groupe, the annual luncheon welcomed leading entrepreneurs to Madam C.J. Walker’s historic estate in New York to celebrate four accomplished women making an impact in their respective industries.
The PAW Patrol® unleash their superpowers in Nickelodeon and VStar Entertainment Group’s newest live stage show PAW Patrol™ Live! “A Mighty Adventure” at the Fox Theatre March 26 and 27
(DETROIT – October 26, 2026) – Nickelodeon and VStar Entertainment Group proudly present PAW Patrol™ Live! “A Mighty Adventure.” The latest live stage show takes fans on a super-powered adventure inspired by PAW Patrol:
Political, union groups endorse Minnesota school board candidates
A handful of political groups and unions are endorsing Minnesota school board candidates in what have traditionally been nonpartisan races.
Live Life Fully: Stress, anxiety and the elections home stretch
The polls. The commercials. The group text that should come with a blood-pressure cuff.
With a congressional seat on the line, political groups race to win over undecided Colorado voters
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Wilmington Health facility sells for $9.4M
Wilmington Health’s main facility recently sold for more than $9 million. The 66,000-square-foot facility located at 1202 Medical Center Drive was purchased by Charlotte-based real estate investment firm Cedar Square in a $9.4 million sale-leaseback transaction, according to a deed recorded Oct. 21. Wilmington Health will continue leasing the facility, CEO Jeff James told the Business Journal in September. James said the lease term would likely be five years, with most services eventually transferring to a new medical office building under construction in the Midtown Park office area near The Pointe at Barclay. The Wilmington Health facility was originally listed earlier this year at $11.85 million. A Wilmington Health representative did not respond to a request for comment by press time. Steve Hall, vice president of BlueCoast Commercial, represented Wilmington Health in the transaction. “Wilmington Health wanted to unlock the value in its real estate without disrupting a single patient visit, and a sale-leaseback let them do exactly that,” said Hall in a text to the Business Journal Monday. “Cedar Square gets a long-term, absolute net investment anchored by one of the region’s leading physician groups, and Wilmington Health keeps its home on Medical Center Drive while redeploying that capital into care.” The sale marks Cedar Square’s first entry into the Wilmington market, according to Jon Dixon, the firm's managing partner and founder. “We are attracted to Wilmington's growth and what we see as strong long-term fundamentals,” said Dixon in an email Monday. “Population growth, relative affordability, and quality of life make it a compelling market for us. The climate and proximity to the coast are a big part of that appeal.” He added, “We hope to pursue additional opportunities across retail, industrial, medical office and multifamily in Wilmington. We will evaluate opportunities individually and remain disciplined about the properties we pursue. We would like this acquisition to be the beginning of a broader investment presence in Wilmington.” Given the facility’s age, Dixon said the site could eventually be redeveloped, potentially for medical office space or housing. Dixon said recent announcements from UNC Health and Atrium were among the factors behind the firm’s growing interest in Wilmington’s medical-office market. The announcements involve competing proposals for hospital expansion in New Hanover County, which are subject to the state’s Certificate of Need process. “Medical office remains one of the most sought-after asset classes in commercial real estate,” said Hall, “and well-located (medical office buildings) with strong operators are scarce in Southeastern North Carolina.” According to Dixon, Cedar Square describes itself as a boutique, hands-on real estate investment firm that values direct relationships with tenants and the communities where it owns property. “We’re very hands-on, and we like to be in direct contact with all of our tenants and the communities in which we own,” Dixon said. He added, “We’re definitely interested in building a presence with local owners, brokers and businesses or tenants.”