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Connections: Sports Edition today: Hints and answers for Oct. 25, 2026, puzzle No. 762
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Guest Commentary: How anti-Muslim politics endangers every Floridian
The political caricature of Muslims as a national security threat bears little resemblance to the reality that Floridians are living, working, and raising families in peace with nearly half a million Muslims woven into the fabric of the state.
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Colorado and Washington are reliably Democratic states where elected officials have rejected moves to ban transgender women and girls from female sports competitions. Now activists have gone around lawmakers to put proposed bans on both states’ ballots.
Game status update for Browns CB Denzel Ward against Titans
Cleveland gets an update on the status of their top cornerback.
Mateer Manages Himself and Mississippi State in Win
Silencing critics in Starkville, John Mateer delivered a poised, turnover-free performance to ignite the Sooners' offense and justify Brent Venables’ unwavering faith during a high-stakes road victory.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
On Invoking History
Bruno Fernandes’ post-match interview after the humiliating loss to Como took aim at many things, including the tendency to analyse the club’s present in relation to its past. Fernandes wasn’t disrespecting it but suggesting that these are very different times. Just a week earlier, Lisandro Martinez stated that we don’t have to go that far […]
State College Area Liquor Store Moving to New Location
A State College area liquor store will move a short distance to a new location early next year. The state-owned Fine Wine & Good Spirits store at 127
Opinion | Trump Should Stay Out of Brazilian Politics
The president seems not to understand that the global standing of the United States suffers when he plays into the stereotype of the ugly American.
Nebraska volleyball vs. USC live updates, stats and highlights
Nebraska hosts USC in a Big Ten volleyball match on Saturday night. The Huskers are undefeated through 20 games for the 10th time in program history.
Cuts to rural healthcare become key issue for upstate votes in race for NY governor
The fight over a consolidation plan for a hospital in Hudson captures a trend throughout the state.
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
UCLA’s perfect start has one glaring flaw it must fix soon
Bob Chesney has made UCLA the second-half darlings of college football, but the Bruins must address their slow starts if they hope to reach the playoff.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
As the US and China form AI blocs, countries are increasingly torn between them
With the two leading AI powers, the United States and China, forming their own AI blocs, other countries are maneuvering to harness the strengths of both groupings without alienating either and risking losing out.
An Iowa Republican’s Unusual Connection to the Kochs (and Kansas)
In his campaign for governor, Zach Lahn has pitched himself as a self-made businessman. His backstory is more complicated.
Cowboys Standout in Second Half in Win Over Colorado
Oklahoma State's defense stifled Deion Sanders’ Buffaloes while the offense exploded for 37 unanswered points, turning a halftime deficit into a dominant Homecoming rout at Boone Pickens Stadium.
Trump casts his midterm ballot early in Florida
Trump has been criticized in the past for voting by mail despite his long history of railing against that method of submitting ballots.
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
Denzel Ward to take part in pregame warmups
Denzel Ward's status for Week 7 remains in question
How to build a police state
To understand where Trump is trying to take the US, we should look to the authoritarian playbook of his favorite ally: El Salvador’s Nayib Bukele
Tri-state people in business: New hires, promotions, recognitions
Medical Associates Clinic of Dubuque announced the following new hires:
Cougars picture-perfect Homecoming scene goes sideways
When the meeting between Washington State and Boise State was announced, it was immediately circled by many to be one of the better games of the revamped Pac-12 slate. Especially in the timeslot it was put in. A late October matchup at 3pm in Pullman. College football is arguably at its peak around this time […]
He Took Big Risks to Make Billions. He Wants Georgia Voters to Bet on Him.
Rick Jackson’s run for governor as a political nobody was his latest gamble. The campaign has brought scrutiny to the businesses that made him a fortune.
Who Did It? ‘Clue’ National Tour Brings Murder-Mystery Comedy to Penn State
Was it Professor Plum? Mrs. Peacock? Maybe Colonel Mustard? Penn State audiences can try to solve the mystery for themselves when the touring stage
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
He Took Big Risks to Make Billions. He Wants Georgia Voters to Bet on Him.
Rick Jackson’s run for governor as a political nobody was his latest gamble. The campaign has brought scrutiny to the businesses that made him a fortune.
Union to Dedicate Historic Marker Commemorating Battle of Connecticut Farms as Part of America's 250th Celebrations
Union – The Township of Union Planning Committee for the 250th Anniversary of the United States, in partnership with the Union Township Historical Society, invites residents and history enthusiasts...
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake
The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.
Birmingham City v Charlton Athletic
Follow live text commentary, score updates and match stats from Birmingham City vs Charlton Athletic in the Women's Super League
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Why partisan politics may be changing people's accents
With the midterms fast approaching, communicating just the right message has been top of mind on all sides of the political aisle
USC Legend Tells Lincoln Riley "It just Ain't Working Out" as He Calls for "Tough Decisions" at His Alma Mater
Lincoln Riley is running out of excuses, and USC is running out of patience. Just a week after showing promise against Penn State, the Trojans embarrassed themselves in a 24-7 loss to Wisconsin, exposing an offense that looked completely lost.
Trump, Who Once Called Early Voting ‘Ridiculous,’ Casts a Midterm Ballot
The president voted at a polling station in Palm Beach County, Fla.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
READERS' CHOICE | Impact Realty Group makes its mark with Best Small Business win
A locally owned and operated real estate brokerage has been named Best Small Business in the 2026 Texarkana Gazette Readers' Choice Awards.
A New Level of Threat and Fear Risks Pushing the U.S. and Iran Back to Full War
With new intelligence and the possibility of all sides seeking pretexts for action, the war in Iran is entering a dangerous phase ahead of elections in the United States and Israel.
How data centers became a bipartisan political issue in Wisconsin
Data centers are a big issue across the country. As midterms approach, many look to the swing state of Wisconsin for lessons for how that issue could play out nationally.
The Long Life of the ‘Snacking Occasion’
As eating habits shift, the food industry is promoting any opportunity to nibble.
Josh Brolin credits strict morning ritual with helping him stay sober for 12 years
Josh Brolin revealed the moment he woke up on a sidewalk outside his house and questioned the direction of his life, leading to 12 years of sobriety.
DOE expands tribal energy funding to $125M, selects 63 projects
The Department of Energy expanded a $50 million tribal energy funding opportunity to more than $125 million after tribal applications sought roughly 10 times the initial amount. The agency selected 63 tribe-led projects across 16 states for what it described as the largest single investment in the Office of Indian Energy’s history. The projects include […]
Health Ministry announces national clinical trial of psychedelic substances for treatment of PTSD
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Obama compares Trump's White House renovations to 'Saddam Hussein opening a Cheesecake Factory' at Ohio rally
Barack Obama compared Trump's White House renovations to a Cheesecake Factory run by Saddam Hussein at a Cleveland rally for Ohio Democrats.
Atomic Wings CEO Zak Omar on leadership, family and building the business
Atomic Wings CEO Zak Omar shares how family, personal challenges and lessons in leadership helped shape his career and grow the chain to 35 locations.
In Deep Red Kansas, a Trump Loyalist Fights to Defend a Senate Seat
Senator Roger Marshall was slow to recognize the steep challenge he faced in his solidly conservative state. Now he is confronting dissent among voters with deep economic worries.
N.C. State fires football coach midway through his 14th season
N.C. State has fired its head football coach a day after falling to Stanford, school officials said Saturday evening in a news release.
Latest Karl-Anthony Towns Update is Good News For Warriors
The Golden State Warriors need to find creative routes to improve the roster with Stephen Curry starting to hit the late chapters of his career. NBA pundits have started to question whether the New York Knicks will retain Karl-Anthony Towns. Recent reports have shown Towns and the Knicks far apart on the extension talks of […] The post Latest Karl-Anthony Towns Update is Good News For Warriors appeared first on HEAVY.
Deion Sanders Forced to Turn to 5th Different QB Since Son Shedeur’s Exit as Colorado’s Offensive Struggles Hit All-Time Low
Deion Sanders traveled to Stillwater searching for answers under center. Instead, Colorado’s heavy 57-24 loss to Oklahoma State exposed a deeper crisis.
Which AMD CPU Is Equivalent To The One In The PlayStation 5 Pro?
Exploding console prices have led gamers to look for an AMD CPU that's equivalent to the one in the PlayStation 5 Pro. The closest match is the Ryzen 5 5600x.
Small businesses struggling with inflation amid Trump tariffs ahead of midterms
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Takeaways from BYU’s Exhibition Win Over UNLV
BYU finished off its preseason slate with an 89-77 exhibition road win over UNLV Saturday afternoon in Las Vegas. BYU won a closed scrimmage 102-53 versus Long Beach State, beat Nebraska 72-61 last week, and closed things out with a double-digit win over the Rebels. BYU trailed 42-30 late in the first half, but ended […]
"Marvel's Wolverine" Topped Game Sales Chart
PlayStation and Insomniac Games’ “Marvel’s Wolverine” debuted as the best-selling game of September in the United States, according to analytics firm Circana. Using the full game sales data of both physical and digital copies, the PlayStation 5 exclusive delivered the highest launch-month dollar sales for a Sony-published game since “Helldivers II” in early 2024. That […]
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
More than barbecue: Lexington festival brings big business and a community together after devastating fire
My Co-Worker Is Losing It Over My Religion
Plus: Reader responses to a woman returning to the office after two decades of self-employment.
Bethune-Cookman scores wild upset victory over Jackson State
The 2026 football season has delivered upsets and stunning losses, but this one might be the most shocking. Over the past two seasons, Bethune-Cookman has gained momentum as a formidable SWAC East contender, but it needed a definitive win over one of the conference’s top teams to prove its worth . Today, that victory came. Bethune-Cookman secured a […] The post Bethune-Cookman scores wild upset victory over Jackson State appeared first on ClutchPoints.
KIII 3 News
KIII 3NEWS is the ABC affiliate in Corpus Christi, Texas, operating to serve, inform and improve communities in the Coastal Bend. The station began broadcasting in South Texas on May 4, 1964. Today, KIII 3NEWS dominates one of the fastest-growing markets in Texas. The station’s service to the community and commitment to local news and weather coverage has consistently made it the Coastal Bend's news leader for decades.
Takeaways from Colorado's disastrous 57-24 loss to Oklahoma State
Oklahoma State fell to Colorado after an abysmal second-half collapse. Here are five takeaways from the Buffaloes' fifth straight loss.
Explosion, fire blast through Iowa Quaker Oats plant
An apparent explosion at the Quaker Oats plant in Cedar Rapids sent thick black smoke over downtown Iowa as firefighters battled the massive blaze.
Ranking Ohio State’s remaining games from easiest to hardest
With Julian Sayin out indefinitely, Ohio State’s final five games will define their playoff hopes. Here’s how those opponents rank, from easiest to toughest
Jennifer Hawks explains why she should be California's State Treasurer
Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.
Early voting underway in upstate New York
Early voting continues through Nov. 1 and Election Day is Nov. 3.
Sarkozy's son warns violent protests in France could worsen amid political unrest
Louis Sarkozy, son of former French President Nicolas Sarkozy, discusses violent unrest in France, the influence of far-left groups and the country’s immigration and economic challenges.
In Arkansas, Democrats see an opening at the edge of the competitive midterms map
In a sign of the potentially dire midterm political environment, Republicans have spent millions of dollars playing defense in Arkansas, one of the most conservative states in the country.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
Scientists May Have Discovered Why Men's Prostates Enlarge With Age
Fascinating new thing.
FEMA deadline approaching for NW Indiana residents, businesses impacted by Aug. 11 storms
Colorado's collapse brings more scrutiny on Deion Sanders
Colorado's 57-24 loss to Oklahoma State raises questions about Deion Sanders and his staff after a second-half collapse extended the losing streak.
Amendment 87 can help support Colorado health care; no to tax increases; and more (Letters)
Amendment 87 gives Colorado a way to respond to our health care affordability crisis. New income tax revenue would be set aside for health care, K-12 public schools, and early child care, with an annual independent audit. For 97% of…
Finding biomarkers for aggressive prostate cancer
Proteins linked to the immune system, cell adhesion, blood vessel formation, and known prostate cancer genes, were associated with the future risk of developing prostate cancer, including aggressive disease, in a new study led by researchers at Oxford Population Health.
EXHIBITION GAME THREAD: RV Marquette vs #6 Michigan State
It’s mostly real basketball at Fiserv Forum, what’s not to like?
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
‘Talking to every single person matters’: ‘prairie populists’ canvass the rural US heartland to win in midterms
Democratic and independent candidates stump the US midwest and prairie states, hoping to win over Republican strongholds
CEO SUNDAY: Atomic Wings CEO shares his journey from Wall Street to the restaurant business
Atomic Wings CEO Zak Omar shares how his father’s influence, a leukemia diagnosis and a commitment to customer service shaped his path to building a 35-location restaurant chain.
NO LOVE? South Florida Seemingly Shuns the Miami Marlins
It's a sad state of affairs when the city's MLB team might be the sixth-most popular team in their own hometown
Science Hill lost in the TSSAA state volleyball finals on Friday
Franklin's win capped a banner day for Nashville-area Division I programs as they teams swept the Class A (Eagleville), AA (Valor Prep) and AAA championships.
Neuroscientist discusses how alcohol can affect brain volume and long-term health
Josh Gowin explains how research has shifted the understanding of alcohol's health risks, including its association with reduced brain volume, as drinking habits and social norms continue to change.
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
'All INdiana Politics': Engling, Ballard clash over restoring credibility to Indiana Secretary of State Office
INDIANAPOLIS — On Sunday’s edition of “All INdiana Politics,” Government Reporter Garrett Bergquist sat down with two candidates who are running for secretary of state, Republican Max Engling and independent Greg Ballard. Both candidates outlined contrasting approaches to restore credibility to an office plagued by controversy under outgoing Secretary Diego Morales. They both presented different […]
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots
The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.
Powers Health Community Hospital Achieves Statewide Milestone in Treating Heart Valve Conditions
Powers Health Community Hospital has successfully performed Indiana’s first procedure using the SAPIEN M3™ transcatheter mitral valve replacement (TMVR) system, a minimally invasive treatment for …
Sacha Baron Cohen says 'Ali G: Who Iz I?' is his last in this style of comedy, calling them too risky
Sacha Baron Cohen reveals why "Ali G: Who Iz I?" will be his last over-the-top comedy, citing dangerous stunts and severe dehydration on set.
Democrats Have Edge Across Four Key House Races in Pennsylvania, Polls Find
Democratic candidates are ahead in two, hold a narrow edge in a third and are tied in a fourth, new polling shows. The seats embody the fights playing out nationwide in the midterms.
Scientists May Have Discovered Why Men's Prostates Enlarge With Age
Fascinating new thing.
Colorado high school students get a head start on healthcare careers
Trump started a trade war with Canada. GOP candidates became casualties.
High tariffs on Canadian goods have turned into a liability for Republicans in key midterm races, particularly those in northern border states.
Meet the volunteers helping adults navigate their health
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily
Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.
Texas opens as heavy favorite against Mississippi State
The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.
BREAKING: Courtois out against Barcelona
Real Madrid have announced that goalkeeper Thibaut Courtois will not play against FC Barcelona tonight. Per Realmadrid.comCourtois is a last-minute drop due to a flu process for tonight’s match between Real Madrid and Barcelona, corresponding to the tenth round of the League. Illia Voloshyn enters the squad list in his place. This is devastating news […]
Trump campaigns in Michigan one day after Obama rallied against him
President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.
On Christ the King and the idolatry of politics
Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]
Indiana high school girls soccer state championship schedule, semistate results
Here is the full schedule and pairings for the Indiana high school girls soccer state championship round on Saturday.
Miami's Israeli gold rush: Michelin-starred restaurants, billion-dollar deals and booming businesses
From a Michelin-starred kosher restaurant and Eyal Shani's growing presence to massive real estate deals, Israeli businesses are flourishing in Miami; but soaring costs, bureaucracy and distance from family are testing the American dream