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Iowa Division of Credit Unions announces leadership transition

Kevin Gorman has been appointed interim superintendent of the Iowa Division of Credit Unions, succeeding Katie Averill, who is stepping down to accept a position in the private sector, the Iowa Department of Insurance and Financial Services announced. Gorman assumed the role Oct. 23. Averill had served as superintendent since her appointment in 2017. Gorman…

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Oct 28 • 12:48 PM EDT • Business • businessrecord.com
Jay-Z burnishes his legend at SoFi Stadium

After earlier stadium shows in New York, London and Paris, the 56-year-old rap superstar touched down in Inglewood for a set overflowing with hits.

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Oct 24 • 3:46 PM EDT • Entertainment • latimes.com
Jay-Z picks himself to headline the Super Bowl halftime show

The man who has helped produce the Super Bowl halftime show is stepping into the spotlight: Jay-Z will headline the show himself.

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Oct 27 • 10:12 AM EDT • Entertainment • flcourier.com
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center

The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.

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Oct 25 • 3:00 PM EDT • Health • loudountimes.com
Jay-Z said he’ll just do the Super Bowl Halftime Show himself

By Lisa Respers France, CNN (CNN) — The NFL didn’t have to look far for next year’s Super Bowl Halftime Show performer. Rapper and entrepreneur Jay-Z, who has served in an advisory role to the NFL through his company Roc Nation since 2019, announced he will perform at the Super Bowl LXI Halftime Show in

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Oct 26 • 10:21 PM EDT • Entertainment • kvia.com
New Paterson pantry serves freshness, health, and hope

The “supermarket experience” is back at the People’s Choice Father English Food Pantry in Paterson, N.J. Thanks to a recent two-year, more than $600,000 renovation, this essential social-services facility is brighter and more welcoming, with a larger — and fresher — food selection to benefit local families and individuals in need. On Oct. 19, Bishop Kevin J. Sweeney blessed the refurbished 4,000-square-foot food pantry. The improvements have allowed the facility to return to its approach of restoring the dignity of clients experiencing food insecurity by enabling them to shop as they would in a commercial supermarket. Guests receive “shopping points”

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Oct 27 • 8:53 AM EDT • Health • beaconnj.org
TMSM Weekly Recap: Star Wars Super Bowl, Cap Lifts Thor's Hammer, Halloweentown 5 and More

Missed anything? Here are the biggest Disney stories from October 18 to 24, from Star Wars Funday Football and Avengers: Doomsday to Halloweentown 5 and Gideon's new trading cards.

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Oct 25 • 6:24 PM EDT • Entertainment • themainstreetmouse.com
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Q&A: Bats, busted myths and the science behind their superpowers

In this Q&A, UNC Charlotte bat researcher Laurel Yohe discusses what makes these animals so fascinating, clears up common misconceptions and shares highlights from her research in the field and the lab.

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Oct 27 • 10:15 AM EDT • Science • newswise.com
2027 Super Bowl halftime show performer is officially announced

This year's NFL championship will take place Feb. 14 at SoFi Stadium.

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Oct 27 • 6:00 AM EDT • Entertainment • syracuse.com
China's super-secret space plane visible in clearest photo yet

The U.S. quietly dropped the picture inside a recent unclassified report.

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Oct 27 • 2:51 PM EDT • Science • popsci.com
Are Chelsea finally playing the brand of football Sonia Bompastor wants - and is it WSL title-worthy?

Digital journalist Laura Hunter returns for a second season with a WSL-dedicated column, analysing all the big talking points from across the weekends action; this weeks focus is on Chelseas resurgence and Man Utds swift development under Eva Olid

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Oct 27 • 7:45 AM EDT • Sports • skysports.com
Sportsbooks, Prediction Markets Set Records for Political Spending

Sportsbooks routed more than $80 million through a super PAC as the AGA and Kalshi stepped up lobbying in a fight over prediction markets.

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Oct 24 • 3:27 PM EDT • Politics • rg.org
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing

Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.

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Oct 25 • 8:08 PM EDT • Sports • sports.yahoo.com
These superbugs pose the biggest threat to Americans, CDC says

Nineteen drug-resistant germs cause an estimated 9.7 million infections and 50,800 deaths in the country each year.

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Oct 27 • 1:00 PM EDT • Health • washingtonpost.com
Kane primed to pip Yamal, Mbappe to Ballon d'Or glory

England captain Harry Kane is the favourite to win a wide open race to be crowned Ballon d'Or winner at a glitzy London ceremony on Monday, with Lamine Yamal and Kylian Mbappe also in the running to be named the world's best footballer.- 'I deserve it' - Yamal finished second to Paris Saint-Germain's Ousmane Dembele last year and the 19-year-old Barcelona superstar seems destined to be a Ballon d'Or winner one day.

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Oct 26 • 12:34 AM EDT • Sports • sports.yahoo.com
Seahawks should consider trading for Jaguars WR Brian Thomas Jr.

Brian Thomas Jr. may give the Seahawks more of a lift toward winning the Super Bowl after the team recently traded for superstar guard Quenton Nelson.

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Oct 28 • 9:00 PM EDT • Sports • sports.yahoo.com
Houston Museum of Natural Science to launch new Marvel exhibit in December

The Houston Museum of Natural Science will debut Marvel: The Exhibition—Universe of Super Heroes on Dec. 18 for members and Dec. 19 for the public.

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Oct 27 • 4:32 PM EDT • Entertainment • communityimpact.com
Jay Z will headline the Super Bowl halftime show in 2027

Jay-Z has been announced as the Super Bowl LXI halftime show performer, capping a banner year by doing something few artists have: choosing himself to headline one of the world's biggest stages for the first time ever.

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Oct 26 • 10:06 PM EDT • Entertainment • charlotteobserver.com
NFL Week 8 power rankings: Seahawks rise, Raiders plummet

The NFL is now entering Week 8, and we don't have any clear Super Bowl favorites yet. Here are our latest power rankings:

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Oct 27 • 3:38 PM EDT • Sports • sports.yahoo.com
Draymond Green Doubles Down On Bold Luka Doncic Take

The MVP race will see a lot of names hoping to make a mark, including Los Angeles Lakers superstar Luka Doncic. Despite being a top five player for many years now, the NBA voters have never voted for Doncic to win an MVP Award. Golden State Warriors legend Draymond Green chimed in before the season […] The post Draymond Green Doubles Down On Bold Luka Doncic Take appeared first on HEAVY.

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Oct 27 • 2:12 AM EDT • Sports • sports.yahoo.com
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Today’s Papers – Lazio fly high, Roma comeback, furious Allegri

La Gazzetta dello SportFantastic draw.Crazy 3-3 between Napoli and Roma. Allegri was sent off; it was a fury.Super hot headLazio, a night as queen: +3 Inter; catching up is on the tableMilan: Cardinal...

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Oct 25 • 4:40 AM EDT • Sports • sports.yahoo.com
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The Science Behind Jalen Hurts’ Controversial Blood Clot Diagnosis Is More Complicated Than It Looks

The Philadelphia Eagles quarterback played with a “superficial” blood clot that turned into something much more serious. Where did things go wrong?

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Oct 28 • 9:00 AM EDT • Science • sports.yahoo.com
"I Didn't Seek Help": Terry Bradshaw Reveals Mental Health Struggle; Credits Wife for Pulling Him Through the Darkest Moments

For decades, 4x Super Bowl Champion Terry Bradshaw was hailed for his chirpy, fun-loving personality, but only a few knew the battle he hid under his jokes. Bradshaw struggled to understand that battle for a long period, dealing with darkness that kept returning even when his life was supposedly going well.

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Oct 25 • 6:30 PM EDT • Health • sports.yahoo.com
Final Kansas high school flag football rankings: USA TODAY Sports Super 10

St. James Academy won the inaugural KSHSAA flag football state championship, earning the top spot in USA TODAY Sports Kansas Super 10 flag football rankings.

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Oct 27 • 6:01 PM EDT • Sports • sports.yahoo.com
'Supercharging bras': The story behind Victoria's Secret's $6 billion business turnaround

Victoria's Secret is in the midst of a historic comeback, with sales surging and its stock on track to notch its best-ever year. What gives? https://bit.ly/4BhD84S

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Oct 25 • 5:21 AM EDT • Business • linkedin.com
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Jay-Z Bravely Chooses Himself To Headline The 2027 Super Bowl LXI Half-Time Show

In an act of supreme nobility and humility, rap mogul Jay-Z has been selected to perform at the 2027 Super Bowl LXI Half-Time show, marking his first time headlining the ...

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Oct 26 • 11:33 PM EDT • Entertainment • manofmany.com
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California

Jay-Z will headline the Super Bowl halftime show on February 14 at SoFi Stadium in Inglewood, California.

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Oct 26 • 9:50 PM EDT • Entertainment • clickorlando.com
‘Keep In-House Business In-House,’ ‘Don’t Put A Target On My Boy’ — Super Bowl Champ Irritated By Jonathan Taylor’s Wife’s Take on Trade Rumors

Things are getting messier by the day for the Indianapolis Colts. Sitting at 2-5 after arguably their worst three-game stretch of the season, the franchise has already parted ways with general manager Chris Ballard.

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Oct 26 • 10:35 AM EDT • Business • sports.yahoo.com
WSL: Crystal Palace host Chelsea in first of five games

Follow live coverage of Crystal Palace host Chelsea in the first of five Women's Super League games on Sunday.

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Oct 25 • 7:12 AM EDT • Sports • sports.yahoo.com
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California

Jay-Z will be the featured performer for the halftime festivities on Feb. 14 at SoFi Stadium in Inglewood, California.

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Oct 27 • 7:06 AM EDT • Entertainment • inquirer.com
CSULB scientists trade lectures for liquid nitrogen at Science LIVE!

Skeltons, superconductors and a grin at the sun: CSULB scientists brought families into the lab at Science LIVE!

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Oct 26 • 4:26 PM EDT • Science • csulb.edu
DoorDash to Buy Instacart for $17 Billion in Big Consolidation for Grocery Delivery

DoorDash is gobbling up Instacart in a $17 billion acquisition that will supercharge its grocery delivery business. DoorDash said the Instacart brand name and app will remain, and Instacart shoppers can continue fulfilling orders for Instacart. Grocers can also choose to work with Instacart or ...

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Oct 29 • 8:04 AM EDT • Business • usnews.com
Chase Briscoe on Pole for NASCAR Cup Race at Talladega

Chase Briscoe is in the best position to go back-to-back in the fall NASCAR Cup Series race at Talladega Superspeedway, winning the pole for Sunday's Yellawood 500 and gaining points on the championship from the get-go.

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Oct 24 • 7:30 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

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Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com
Padres Are Well-Represented Among AFL 's Statcast Superlatives

From hitting to pitching to throwing, three San Diego Padres' minor-leaguers are ranked highly in advanced metrics in the 2026 Arizona Fall League season.

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Oct 27 • 4:26 PM EDT • Sports • sports.yahoo.com
Nintendo reveals why you don't actually fight Bowser in Super Mario Bros. 1

Nintendo’s Shigeru Miyamoto has shared some insight into why players don’t actually fight Bowser in the original Super Mario Bros. Miyamoto was present at a press conference at the end of the week to celebrate him becoming the first developer to win Japan’s Order of Culture award. During the event, he was asked to share behind-the-scenes stories about the making...

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Oct 25 • 2:15 PM EDT • Technology • nintendoeverything.com
MiAsia Symone on the latest entertainment headlines

Jay-Z has officially been announced as the Super Bowl halftime performer and fans have things to say. Plus retired NBA standout, Paul Pierce is rumored to be struggling financially.

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Oct 28 • 11:01 AM EDT • Entertainment • fox5atlanta.com
These superbugs pose the biggest threat to Americans, CDC says

Nineteen drug-resistant germs cause an estimated 9.7 million infections and 50,800 deaths in the country each year.

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Oct 27 • 1:00 PM EDT • Science • washingtonpost.com
Chiefs vs. Seahawks live updates, inactives, where to watch: Kenneth Walker III faces Seattle for first time since Super Bowl MVP run
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Oct 25 • 7:01 PM EDT • Sports • sports.yahoo.com
Micah Parsons could make the Packers legitimate Super Bowl contenders

Micah Parsons is inching closer to a return. It could be the thing that makes the Packers a legitimate Super Bowl contender.

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Oct 29 • 7:03 AM EDT • Sports • sports.yahoo.com
Tom Brady, Candice Swanepoel have been dating since June: report

Football hero Tom Brady and supermodel Candice Swanepoel have reportedly been dating since June. The pair have kept the relationship quiet by spending time together in Indian Creek, Fla., 30

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Oct 26 • 4:47 PM EDT • Entertainment • recorderonline.com
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California

Jay-Z will headline the Super Bowl halftime show on February 14 at SoFi Stadium in Inglewood, California | WBBM Newsradio 780 AM & 105.9 FM

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Oct 26 • 9:52 PM EDT • Entertainment • audacy.com
The Super Mouse puts a touchscreen macro pad under your hand

It’s a bird, it’s a plane — no, it’s a mouse with a touchscreen.

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Oct 27 • 1:00 PM EDT • Technology • theverge.com
Watch: Chris Pratt teaches courage, resilience in ‘Way of the Warrior Kid’ trailer

Chris Pratt is trading superhero battles for a different kind of fight in the upcoming Apple TV film Way of the Warrior Kid, a family adventure exploring resilience and the meaning of true courage

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Oct 28 • 11:08 AM EDT • Entertainment • christianpost.com
Supercurrent enables the reading of quantum information without destroying it

One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...

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Oct 25 • 3:00 PM EDT • Technology • phys.org
Birmingham City v Charlton Athletic

Follow live text commentary, score updates and match stats from Birmingham City vs Charlton Athletic in the Women's Super League

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Oct 25 • 8:50 AM EDT • Sports • sports.yahoo.com
Frank Zhao and Zhengguang Lu Win 2026 LOR Science Prize

Frank Zhao and Zhengguang Lu share the 2026 Lee Osheroff Richardson Science Prize for research on unconventional superconductivity and topological states.

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Oct 28 • 8:19 AM EDT • Science • thequantuminsider.com
Jay-Z Announced as 2027 Super Bowl Halftime Show Performer

It will be the eighth Super Bowl halftime show produced by Roc Nation, the entertainment and sports company founded by the rapper and businessman.

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Oct 26 • 9:50 PM EDT • Entertainment • nytimes.com
Superbugs are becoming a bigger public health threat, CDC warns

Drug-resistant infections kill more than 50,000 Americans every year. Those caused by C. Auris are up nearly tenfold since 2019.

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Oct 28 • 3:11 PM EDT • Health • phillyvoice.com
The PAW Patrol® unleash their superpowers in Nickelodeon and VStar Entertainment Group’s newest live stage show PAW Patrol™ Live! “A Mighty Adventure” at the Fox Theatre March 26 and 27

(DETROIT – October 26, 2026) – Nickelodeon and VStar Entertainment Group proudly present PAW Patrol™ Live! “A Mighty Adventure.” The latest live stage show takes fans on a super-powered adventure inspired by PAW Patrol:

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Oct 26 • 10:47 AM EDT • Entertainment • 313presents.com
Heralded Arkansas freshman Abdou Toure signs with rapper Rod Wave's sports agency

Every now and then pop culture and sports collide. Rap superstar Rod Wave has been involved in sports for a few years now, and on Wednesday his agency announced a major move. It has signed Arkansas true freshman basketball star Abdou Toure. Rod Wave announced the signing on Instagram, hailing its deal with the Arkansas […]

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Oct 28 • 2:04 PM EDT • Sports • sports.yahoo.com
Jay-Z will headline the Super Bowl halftime show at SoFi Stadium in Southern California

The man who has helped produce the Super Bowl halftime show is stepping into the spotlight: Jay-Z will headline the show himself | Talk 1370

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Oct 26 • 9:52 PM EDT • Entertainment • audacy.com
Tom Brady Calls Troy Aikman ‘Amazing’ Amid Turmoil With Joe Buck at ‘Monday Night Football’

Tom Brady recently paid Troy Aikman a compliment, as his future in broadcasting remains up in the air. As First for Sports previously reported, Aikman, 59, has been a Monday Night Football commentator for ESPN since 2022, but his deal will expire after Super Bowl LXI in February 2027. The retired Dallas Cowboys quarterback, who […]

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Oct 27 • 4:52 PM EDT • Sports • sports.yahoo.com
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California

Jay-Z will headline the Super Bowl halftime show on February 14 at SoFi Stadium in Inglewood, California | Newsradio 1140 WRVA

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Oct 26 • 9:52 PM EDT • Entertainment • audacy.com
I cofounded GPTZero. Now I worry people can't write without AI.

Edward Tian built GPTZero in college and sold the AI writing detection tool to Superhuman. Now he worries AI is changing how people write and think.

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Oct 27 • 5:00 AM EDT • Business • businessinsider.com
Justin Blandford interview - Illinois Times, the capital city's source of news, politics, arts, entertainment, culture

History is more than dates, buildings and plaques. It’s the stories we choose to remember and the ones we’re still learning how to tell. This week, we sit down with Justin Blandford, superintendent of Springfield’s state historic sites, to talk about some of his favorite projects, the challenges of working with history and the unexpected […]

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Oct 28 • 11:51 AM EDT • Politics • illinoistimes.com
Inside Business 2026 Top Forty Under 40: Julius Delbridge, CHKD Sports Performance Academy

Julius Delbridge is the fitness program supervisor at CHKD Sports Performance Academy.

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Oct 26 • 7:06 AM EDT • Business • pilotonline.com
Supercomputer reveals first two billion years of ‘cosmic web’

The Center for Astrophysics’s simulation offers the most detailed look yet at the infancy of the universe after the Big Bang

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Oct 25 • 8:01 PM EDT • Science • thetimes.com
Jalen Brunson Remembers Bulls Legend Stacey King in Heartfelt Message

The Knicks superstar had a message for Bulls fans and the King family after New York's big win.

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Oct 29 • 8:00 AM EDT • Sports • sports.yahoo.com
Super Bowl 2027 halftime show headliner revealed

Jay-Z will headline the Super Bowl 2027 halftime show, with the rapper set to lead the biggest music event of the year at the NFL’s big game.

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Oct 26 • 9:50 PM EDT • Entertainment • ew.com
Inside Business 2026 Top Forty Under 40: Julius Delbridge, CHKD Sports Performance Academy

Julius Delbridge is the fitness program supervisor at CHKD Sports Performance Academy.

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Oct 26 • 7:06 AM EDT • Business • dailypress.com
Luka Doncic Makes NBA History in 50-Point Game in Lakers-Magic

Los Angeles Lakers superstar Luka Doncic was on a different level against the Orlando Magic.

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Oct 26 • 1:16 AM EDT • Sports • sports.yahoo.com
Three giant black holes discovered in a galaxy from the dawn of time

Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.

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Oct 25 • 8:00 AM EDT • Science • sciencedaily.com
Science Pub: El Niño Facts, Myths & Mysteries

What is El Niño—and what makes this year’s super? Many people associate El Niño events in California with unusual animal sightings, heavy rains and flooding, and disruptions to coastal agriculture and fisheries. […]

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Oct 27 • 2:40 AM EDT • Science • edhat.com
Crystal Palace v Chelsea

Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League

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Oct 25 • 9:39 AM EDT • Sports • sports.yahoo.com
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‘That goes beyond party’: Democrat superintendent candidate Jennettie Marshall talks priorities, politics

The Oklahoma general election is days away, and education issues are at the top of voters’ minds. StateImpact’s Beth Wallis sat down with the Democratic nominee for state superintendent, Jennettie Marshall. Marshall is a pastor and former Tulsa Public Schools board member.

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Oct 29 • 5:00 AM EDT • Politics • kgou.org
Super Bowl 2027: Jay-Z will headline halftime show

Jay-Z will headline the Super Bowl LXI halftime show at Inglewood's SoFi Stadium on Valentine's Day.

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Oct 26 • 9:52 PM EDT • Entertainment • latimes.com
High school football rankings: Two new teams enter USA TODAY Sports Super 25

Santa Margarita remains No. 1 as CE King and Edna Karr enter the USA TODAY Sports Super 25 after another wild week of high school football.

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Oct 26 • 6:31 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Jay-Z picks himself to headline Super Bowl halftime show at SoFi Stadium

Jay-Z will headline the Super Bowl halftime show on February 14 at SoFi Stadium in Inglewood, California.

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Oct 26 • 10:27 PM EDT • Entertainment • journalgazette.net
Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid

The Toronto Maple Leafs and Edmonton Oilers are facing one another in a Saturday evening showdown at Edmonton’s Rogers Place, marking the first time in the career of rookie forward Gavin McKenna that he’s facing Edmonton superstar captain Connor McDavid.McKenna, who has previously trained with McDavid over the summer, remains as much in awe of […] The post Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid appeared first on HEAVY.

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Oct 25 • 12:30 AM EDT • Sports • sports.yahoo.com
🙂 Positive (32%)
Animals Starves while the Kardashians Miss the Charts Again

(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) Before we get going, I’d like to offer congratulations to Jonathan Funke, whose suggestion “midflicks” won the poll for what I should call straight-to-streaming films which aren’t big or cinematic enough to go to theaters but seem too expensive for a TV movie. It’s so useful a term, I just used it last week! Now I just need to add this term to my data dictionary! Okay, on to this week’s issue. We’re starting out looking at Netflix/Ben Affleck’s latest crime thriller, Animals. I’ll also look at Disclosure Day heading to Peacock (it did better than you’d remember in theaters...) and a new movie based on toys. Plus, a long-time streaming flop returns for its eighth season...will it finally chart? (No.) Will anyone at Disney care? Probably not. All that, plus another look at new shows landing on streaming on 1-Oct from Reelgood, what streamer hasn’t had a film make the Luminate charts since August, Reacher’s long run on the charts, M_onster: The Lizzie Borden Story’s_ short run, the top shows in 2026 according to Samba TV, all the flops, bombs and misses, and a whole lot more. And I mean that last part: putting this week’s issue together, I assembled OVER 25 images, most of which are bespoke looks I made just for this report. Really, publishing articles like this takes the work of writing two articles: one is the narrative and the other is making charts/graphs. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the week of October 5th to October 11th, 2026. You can find a link to my terminology here.) Subscribe Film - Netflix’s Latest Star-Studded Thriller Goes For Glory The tempting angle for anyone writing about streaming film this month, like yours truly, is to ask, “Is this why Dan Lin lost his job at Netflix?” Take Animals, the Ben Affleck-starring-and-directing, Artists Equity-produced crime thriller that opened on 9-Oct. (Kerry Washington and Gillian Anderson are also in it.) If it did really well, then one could argue that Lin has another success on his resume. If it underperformed, then it’s another example of a Netflix underperformance this year. So where did Animals fall? Kinda in the middle, but that means it’s more “not a hit” than “big hit”. On Nielsen, it opened to 12.0 million hours, and here’s how that stacks up for 2026 films so far this year: Obviously, that’s not great. It’s both under my 15 million opening bar for “fine” for a Netflix film and 20 million bar for “great” opening. It did a bit better on Samba TV, getting to first place. That’s very, very good, though again, looking at the Nielsen data, it probably means that it was a light week overall. Luminate’s data is a bit closer to Samba TV’s, tied for 17th all time for single weeks since May of 2024: To top it off, no one seemed to like it. It has a 33 on Metacritic and only a 5.7 on IMDb. Both of these numbers could have been impacted by the stories about Affleck’s comments about using AI to make the film. Given the controversy, the film might not have been as bad as the ratings suggest, but it’s also not a bullish sign. All to say…yeah, on net this film isn’t a point in Dan Lin’s favor. At this point, Netflix’s slide has been long enough—going on since February—that I’m almost tempted to lower the bar for what a “hit” is on streaming. Post-February of 2026 or so, it seems like straight-to-streaming films just haven’t hit the same heights as they did from 2022 to 2025. Before we head onto the “Quick Hits” for film, I want to shout out a fellow newsletter whose articles I’ve been loving this year, LA Material, a new LA-based news outlet. For just a highlight of my favorite articles since July... I loved this article on Ghost Town, a group on Venice that clears homeless encampments. As a Los Angeleno, obviously I adore their articles on LA parking issues. Their article on illegal parking tickets got the City Council to address the issue! Also check out their article on people parking in medians. Check out their deep dive on what went wrong with the LA Jazz Festival and how it fell apart, or what’s wrong with USC’s finances. Finally, they wrote up a voter guide on voter guides for the LA General Election. So meta! In search of a city? L.A. Material is an independent news outlet covering the people, politics, culture and glorious chaos shaping Los Angeles. L.A. Material brings you intel on the city you can’t get anywhere else. From exploring how Reddit short stories became Hollywood’s hottest commodity to reporting on the survival jobs keeping entertainment workers afloat. And answering, once and for all, why the AMC Burbank escalator is always broken. Through their newsletters, podcast, videos, events, and member community, L.A. Material is designed to help Angelenos connect to Los Angeles and each other. Sign up now for the free weekday newsletter. Quick Notes on Film Steven Spielberg’s latest film, Disclosure Day, came to Peacock on 9-Oct, and I’ll admit that, after pulling its stats, I did a pinch of a double take. As I wrote throughout my deep, deep, deep dive on summer box office/Obsession/Backrooms/IP/superheroes, oftentimes the film media discusses films as “flops” or “misses” or “hits” without clarifying what they specifically mean. Since Disclosure Day didn’t make $250 million in the US or $500 million globally, it was definitely a disappointment by Spielbergian standards, who is the highest-grossing director of all time, and arguably even more ahead in adjusted grosses. But it did make $245 million globally on a $115 million budget, so it isn’t as big of a miss as I remember. That’s still probably not enough to break even in the theatrical window, when you factor in marketing costs…but it’s close. And it grossed a lot more even in the US than some titles with about ten times more coverage. Anyways, lots of preamble to say this one only did 4.5 million hours according to Nielsen, so it did make the charts, but on the low end. Here’s how it stacks up to other Peacock titles: Apple TV (née +) followed up their “success for them” Mayday with Matchbox The Movie. This one doesn’t look like a success even for them, but at least it’s not a miss. Apple/Skydance clearly tried to take advantage of the success of Barbie at the box office—let’s greenlight all the toy properties!!!—but of course, this didn’t make it to theaters. And it stars John Cena, who, as I argued earlier this summer, NEEDS to get his movies back in theaters. Anyways, this one has mixed-to-bad numbers. It missed the Samba TV and Nielsen charts in its first week, but did make Luminate with 7.1 million hours. That’s just enough to not be an outright miss, and about half what Mayday did earlier this summer. Speaking of Apple Studio’s Mayday, it ended up lasting five weeks on Luminate, which isn’t bad for Apple TV. On Nielsen, it had a three-week run, racking up 13.5 million hours total. Again, like Matchbox, the issue is the budget; I doubt that this viewership earned enough to justify that budget. Also, to be clear, neither of these films are “midflicks”; both should have gone to theaters. Toy Story 5 is not hanging around on the streaming charts on Disney+, so it’s not as leggy as either Zootopia 2 or Moana 2, and definitely not in the same class as Encanto. (It did make all the money at the box office, so Disney is going to be fine…) The Breadwinner on Netflix (from Sony) is down to 3.9 million hours in its third week. It only lasted for one week on the Samba TV charts. Netflix’s Doing Life had a smaller-than-normal binge release curve bounce, only going to 7.1 million hours from 6.0 to start, but it made Samba TV at fifth place in its second week. The Netflix documentary, The Widower: Til’ Death Do Us Part, also had a small binge release curve bounce to 6.5 million hours, but did make a second week on Samba TV. Meanwhile, Netflix’s Unabomber fell off after two weeks on Nielsen—which is not great at all—and Demon Slayer fell off after just one week. Over on Luminate, the two smaller titles The Swan: Behind the Mirror and Kill. Bury. Print both fell out of the Luminate top ten charts. The story of library film at the first of the month is the arrival of the Ice Age films on Netflix. Now, here’s a small example of optimizing your library that even Netflix could do better. Say you want to rent/license a new film series from Disney**.** A streamer could pay a big paycheck and then drop each Ice Age film on the exact same day of the month, the fourth of October. That’s one choice. In contrast, the streamer could have released each film one week apart, and make each one a mini-event for folks watching Ice Age films. Or even roll them out monthly. Netflix opted for the former strategy, and as a result, only three of the films made the Nielsen charts this week. The “Miss of the Week” goes to Tubi’s YA-ish horror film_, R.L. Stine’s Pumpkinhead 2_, which didn’t even make the Luminate charts like Tubi films usually do, or, should I say, “used to”? Tubi films, most of which are straight-to-streaming, used to reliably make the Luminate film charts (which only covers straight-to-streaming films), but a Tubi film hasn’t made it since August. The first Pumpkinhead got 1.4 million hours last year according to Luminate. As I wrote about this film before, it seems to be a bit muddled in terms of age: too scary for young kids but probably not scary enough for older kids. Speaking of Luminate, Netflix’s latest doc about a comic (expect more docs about comedians all month), Who Is Martin Mull?, flopped, getting just 200K and 700K hours according to Luminate. Three other film/special misses belonged to Hulu, including a standup special, Jamie Foxx: Take Care of Yourself, Neon’s latest horror film, Hokum, which made $17 million in the US, and a Family Guy Halloween special. (That last one was only 22 minutes, so it’s not a surprise it missed.) Finally, another Netflix standup special missed the charts, Mojo Brookzz: I Know You Lying missed too. I can confirm last week’s misses, most notably Paramount+’s Jackass: Best and Last, MUBI’s Teenage Sex and Death at Camp Miasma and HBO Max’s Evil Dead Burn. Television - I Can’t Visualize Nothing: The Kardashians Story Normally, in the mini-dive essays that open the Streaming Ratings Report, I focus on shows that do well or, at the very least, make the charts. Why? Because as I’ve said time and again, I can’t visualize nothing like, say, the Kardashians’ TV shows. Here’s the TV debuts chart for this week with a missing spot for The Kardashians, whose eighth season just landed on Hulu:

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Oct 27 • 6:17 PM EDT • Entertainment • entertainment.substack.com
📈 Monday data: The bottleneck isn’t intelligence

In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.

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Oct 26 • 11:25 AM EDT • Science • exponentialview.co
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Danhausen sent Pistons ‘fun’ message before Knicks loss

Even though WWE Superstar Danhausen was part of the New York Knicks’ championship , he wished their latest opponents, the Detroit Pistons, well during the game. Shortly after the game began, the “Very Nice, Very Evil” Superstar showed his allegiance to the champions, writing, “Do good Knicks,” on X, formerly Twitter. About 20 minutes later, he […] The post Danhausen sent Pistons ‘fun’ message before Knicks loss appeared first on ClutchPoints.

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Oct 28 • 9:18 AM EDT • Sports • sports.yahoo.com
Green Bay Packers rookie kicker Trey Smack addresses 2 missed kicks in loss to Detroit Lions

The Green Bay Packers lost a handful of games last season because Brandon McManus missed multiple field goals that, at the end of the day, proved to be the difference in various contests. For this reason, the Packers made the decision to move on from the former Super Bowl champion and selected Trey Smack in [...]

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Oct 26 • 5:53 PM EDT • Sports • sports.yahoo.com
USA TODAY Sports Super 10 California high school flag football rankings, Week 10

Here’s a look at USA TODAY Sports latest Super 10 flag football rankings for the state of California.

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Oct 27 • 4:07 PM EDT • Sports • sports.yahoo.com
Sharing Wahine Superpowers That Drive Business Goals and Open Doors for Others

Speakers at the 17th annual Wahine Forum shared tips to navigate workplace friction, take career leaps and build lasting professional networks.

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Oct 26 • 3:26 PM EDT • Business • hawaiibusiness.com
Why do we see ghosts? The science behind spooky encounters

At Halloween, when people share tales of haunted houses, ghosts in the graveyard and things that go bump in the night, Wake Forest University psychologist Melissa Maffeo responds with science. Author of the 2025 book “Science of the Supernatural: Critical Thinking for the Mind and Brain,” Maffeo explores the spooky experiences pop culture often attributes to the paranormal through the lens of neuroscience. She says several key neurological and psychological factors can explain why we see ghosts.

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Oct 28 • 8:32 AM EDT • Science • news.wfu.edu
A golden age of science is coming

It’s almost hard to remember, but just a few years ago, a lot of very smart people thought that science was in terminal decline. Respected researchers were writing papers with titles like “Are Ideas Getting Harder to Find?”, “Papers and patents are becoming less disruptive over time”, and “Slowed canonical progress in large fields of science”. In 1996, science writer John Horgan even published a book called The End Of Science: Facing The Limits Of Knowledge In The Twilight Of The Scientific Age. The fundamental idea was that the Universe only has so many insights to discover, and that we’ve picked the low-hanging fruit. It was the idea that Joseph-Louis Lagrange expressed when he said that “we cannot find more than once a system of the world to establish.” As the big ideas and the simple ideas get mined out, we’re forced to throw ever more brains at the mysteries of nature just to keep scientific progress going at a fraction of its old pace: It looked like science was hitting a wall. Then along came AI. It’s far too early to tell how much AI will eventually speed up the growth of total factor productivity. But already we can see signs of a speedup in science. Anthropic Founder Jack Clark assembled some of the hopeful data points in a recent lecture: [ Dror Poleg@drorpoleg "If you pick different parts of science, you see the same pattern show up: Progress is accelerating, and it has started to accelerate in the last two years." Jack Clark @jackclarkSF I’m speaking at the IMF in an hour about the singularity and why I believe it has begun and the choices we'll need to make. Watch live here: https://t.co/Hj9HzcXx5h 6:08 PM · Oct 18, 2026 · 21.2K Views 2 Replies · 10 Reposts · 123 Likes ](https://x.com/drorpoleg/status/2111882070376980529) Anthropic is accelerating its investment into drug discovery, and is already announcing some impressive preliminary results: [ BioTender@Junioryu136689 BREAKING: Anthropic unveils early results from six Claude-powered drug development collaborations. • 70% shorter CAR-T signaling domain • ~35,000 antibody designs • >10× tighter antibody binding • 89% less batch-record review time Still largely preclinical. Anthropic @AnthropicAI Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of 9:43 PM · Oct 27, 2026 · 11.2K Views 3 Replies · 24 Reposts · 205 Likes ](https://x.com/Junioryu136689/status/2115197821150495150) Claude also appears to be enabling rapid progress toward a treatment for food allergies. OpenAI, meanwhile, announced a possible breakthrough treatment for neurodegenerative disease. Meanwhile, Google Cloud Chief Scientist Pushmeet Kohli has a list of recent scientific advances that have been enabled by its new Gemini model, including breakthroughs in nuclear fusion reactor design, rare disease research, and quantum computing: [ Pushmeet Kohli@pushmeet Gemini 4 Argon is a step change in model performance. In recent weeks, it has had a transformative impact on the Science projects in our team at @GoogleDeepMind and our external collaborators, and helped make a number of remarkable advances across scientific disciplines. 🧵👇 4:47 PM · Oct 13, 2026 · 36.5K Views 8 Replies · 41 Reposts · 497 Likes ](https://x.com/pushmeet/status/2110049807385702623) But as cool as these stories sound, they’re just very minor, preliminary efforts. There are a number of reasons to think that AI is going to propel us into a golden age of scientific discovery. That age might not last forever — AI might still run into diminishing returns eventually. But the next few decades are probably going to be an absolutely amazing time for human science. The number of “effective researchers” is no longer limited The most important input into science is scientists themselves. Until this year, that meant human brains — talented, highly trained human brains. The number of trained human brains could be increased by sending more people to grad school, but only to a point — the smartest people tend to be sent into the hardest research fields first, and if you 10x the number of researchers, the average quality will go down. This constraint was already starting to bite, as Ekerdt and Wu argued in 2024: We argue that a substantial portion of the downward historical trend in U.S. research productivity is a composition effect resulting from self-selection in researcher ability and the dramatic expansion of the research sector…[W]e find that this composition effect has lowered average researcher ability by between 37% and 53%[.] And of course, low fertility was making the problem worse, because fewer children meant fewer people who were able to become future scientists. AI just blows up this constraint completely. If an AI agent can function as an autonomous researcher, there’s no constraint on the number of researchers in the world — you can just build more of them, by building more computer chips and data centers that enable the running of more AI agents. Whether or not massive hordes of agents can collaborate to solve individual problems much faster, increasing the number of agents allows them to tackle many different research questions in parallel. What’s more, these AI “researchers” can be trained incredibly quickly compared to human beings. A human scientist takes decades to train, and more years to reach the frontier of their research field by diligent reading and conversation. This is the “burden of knowledge”, and it’s commonly believed to be one reason ideas have been getting harder to find — by the time human scientists can get up to speed, they’re often so old that their ideas are no longer novel. AI just annihilates this constraint — it can assimilate the entire literature and reach the frontier of research extremely quickly, and it can also tell human scientists where the frontier lies without forcing them to discover that for themselves. It can also pivot to new research directions more easily than humans can. And there’s also a self-reinforcing economic cycle here. Because scientific advances enable higher GDP, they enable more resources to be invested into the creation of yet more electronic “scientists”. Now that doesn’t mean the amount of scientific research goes to infinity — there may still be some essential bottleneck task that human researchers are still needed to perform. There are some indications that AI’s progress on open-ended conceptual research tasks is slower than in other dimensions, and it may be that humans are still needed to provide some of this long-term conceptual thinking. I’d bet against this being true for much longer, but it might be true for a long time. Even in this most “pessimistic” case, though, the amount of effective capital that scientists can use to leverage their work just went up by a lot. AI eliminates the theory bottleneck Science proceeds by an iterative process of theory and experiment. The theory part of that cycle is typically short, but non-trivial — it took a couple of years after the blackbody radiation spectrum was observed for Max Planck to come up with the quantum hypothesis to explain it, and decades longer before quantum theory as we now know it was created. It took about a year for Watson and Crick to figure out the shape of DNA after the requisite data was gathered. AI will basically eliminate the theory bottleneck entirely — or at least shorten the turnaround time between experiment and theory by an order of magnitude. AI is an absolute beast at math. Recently, an OpenAI model solved some of the most important open problems in computer science, math, and theoretical physics, and no one even batted an eyebrow because that sort of triumph is becoming increasingly commonplace. One of those solutions was a proof that the Standard Model of Particle Physics could be mathematically well-defined — a problem that human theorists had so far been unable to tackle. Not all research relies equally on theory, but understanding novel experimental results almost always involves some important component of either mathematical or spatial reasoning. That part of the task has now been made much, much faster. And on top of that, science is now open to a greater number of humans who aren’t naturally good at theorizing. AI can read the whole literature Much of the work of human scientists involves reading and understanding endless amounts of papers and going to endless conferences and seminars. The purpose of that work is to understand the existing scientific literature. Understanding the literature allows scientists to do the following things: Come up with new ideas for hypotheses to test Avoid doing research that someone else has already done Synthesize approaches from different areas or fields AI can reduce this effort to almost zero. Consider this excerpt from OpenAI’s blog post about their new research into neurodegenerative disease: The team divided the analysis among thousands of AI agents powered by GPT‑Rosalind, an approach we call distributed biological reasoning. The agents examined a whole-brain CRISPR atlas…a dataset showing how gene disruptions affect different types of cells across the mouse brain. Each agent investigated a gene disruption, analyzed cellular responses, searched scientific literature, and proposed explanations for the results. Their reports were combined into a reasoning atlas linking genes, cellular effects, relevant publications, and possible biological mechanisms. The research team estimated that comparable human analysis and literature review, conducted one perturbation at a time, would take months to a year. The agents reproduced findings from human analyses while uncovering additional leads. Their assessments of novelty and scientific value also aligned with judgments from blinded human experts. These findings help prioritize further experiments needed to test the proposed biological mechanisms. Some of these insights point to new leads for understanding brain disease. [emphasis mine] This is one case in which parallel work by a large number of agents really does make a huge difference: [ Haider.@haider1 this is actually insane openai deployed thousands of GPT-Rosalind agents to analyze millions of mouse brain cells in 32 minutes, work that could take human researchers months to a year also the agents uncovered new leads for brain diseases like Alzheimer's and Parkinson's OpenAI @OpenAI GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in 2:41 PM · Oct 21, 2026 · 51.5K Views 26 Replies · 95 Reposts · 1.26K Likes ](https://x.com/haider1/status/2112917197903540516) Not only does instantaneous literature review vastly speed up the research process, but it allows AI to make novel conceptual leaps from combining approaches from wildly different fields of research. AI regularly does this in math research, combining results, approaches, and theorems from far-flung places that no human mathematician would have thought to combine. It can do it in science, too. Much of scientific innovation, historically, has been “recombinant” innovation — scientists applying insights from one field to another. With AI, essentially all research is now cross-disciplinary — AI can read not just the literature on a particular subject, but the literature on a million other subjects that might have produced useful techniques or insights for the problem at hand. Superscience So far, all of the factors I’ve listed are ways that AI can speed up science as it’s already done. I’ve basically described how AI can send gigantic hordes of superhumanly fast, superhumanly well-read, superhumanly mathematically gifted researchers to re-accelerate scientific discovery. But it’s also possible that AI will enable types of discovery — and ways of understanding the natural world — that no network of humans, no matter how large or how brilliant it was or how long it had to work, would ever be able to discover. In a post back in July, I wrote about how that might work: What if there are lots of…aspects of the Universe that [are] too complex to understand in terms of simple laws, but not so complex that they just dissolve into unknowable chaos? It’s possible that we can reliably control these complex phenomena with AI, even if we never reduce them to the kind of principles that we can teach a grad student in a textbook… Another way of saying this is that there may be laws of the universe that humans can’t understand but AI can. I call these “cloud laws” — causal regularities that can be exploited by technology, but which are too diffuse and complex for an individual human being to either intuit or communicate… Perhaps social sciences like economics, sociology, and political science obey similarly complex regularities, and AI can help us find them. Perhaps there are physical processes — plasma, or topological materials, or aerial turbulence, etc. — that obey cloud laws instead of chaos?… [H]uman collaboration is bottlenecked — it’s limited by our ability to intuit patterns at an individual level, and to communicate these patterns from one individual to another. AI, being a computer, just doesn’t have this sort of limitation; it can work with vast, diffuse patterns without having to break them into pieces or simplify them in order to compress them into the tiny pipelines of person-to-person explanation… If much of the Universe turns out to be ruled by cloud laws, we could be on the precipice of a scientific renaissance. In order to discover cloud laws, AI will need huge amounts of data about the natural world. AI figured out human speech by assimilating essentially all of the text humans have ever written. If it’s going to figure out hidden patterns in biology, neuroscience, materials science, etc., it’s going to need similarly massive amounts of data from physical instruments. That data will be far, far more than humans — individually or collectively — would be able to parse, label, characterize, or model. But AI was built to do this. If scientists simply build huge arrays of sensors to measure complex phenomena like the brain, the cell, the economy, etc., they may be able to feed this flood of data to AI directly and bypass human cognitive intermediation entirely. AI would then learn about the world directly, and it might learn things that humans never could. This “superscience”, if you want to call it that, would actually go beyond the kind of science humans have done heretofore. Many of the technologies it yielded would be beyond human comprehension — indistinguishable from magic. But to the AIs, they would make perfect scientific sense. In any case, it seems clear that the scientific slowdown that threatened human progress will now be delayed — at least for a while. Unless humans have somehow found most of the actual exploitable regularities in our Universe, we’re about to enter a new golden age of science. Subscribe Share

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Oct 29 • 5:55 AM EDT • Science • noahpinion.blog
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California

Jay-Z will headline the Super Bowl halftime show on February 14 at SoFi Stadium in Inglewood, California. The NFL, Apple Music, and Roc Nation announced the news Monday night. NFL

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Oct 26 • 10:27 PM EDT • Entertainment • yakimaherald.com
Canelo Banks Massive Payday For Halloween Title Fight

Canelo Alvarez will make his long-awaited return to the boxing ring this Saturday (Oct. 31, 2026) for the first time since losing to Terence Crawford over a year ago to face off against WBC’s interim super middleweight champion, Christian Mbilli, inside Kingdom Arena in Riyadh, Saudi Arabia on DAZN PPV. Despite the loss to “Bud” […]

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Oct 28 • 5:00 PM EDT • Sports • sports.yahoo.com
LeBron James’ Philadelphia Experiment Is Already Getting Complicated

LeBron James’ move to Philadelphia was supposed to give the 76ers another superstar capable of helping them compete for an NBA championship. However, just days into the 2026-27 season, the experiment is already facing an unexpected challenge. Philadelphia has started the season with plenty of excitement surrounding its new roster, but injuries and frontcourt concerns…

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Oct 27 • 7:15 PM EDT • Sports • sports.yahoo.com
Houston Museum of Natural Science to launch new Marvel exhibit in December

The Houston Museum of Natural Science will debut Marvel: The Exhibition—Universe of Super Heroes on Dec. 18 for members and Dec. 19 for the public.

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Oct 27 • 4:32 PM EDT • Science • communityimpact.com
Chicago Bears QB Caleb Williams hums during games. Here’s the science behind it

“I've always been super conscious of mind, body and spirit,” Williams said. “It's just something I have learned about myself."

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Oct 29 • 5:00 AM EDT • Science • nytimes.com
DoorDash to buy Instacart for $17bn in major grocery delivery consolidation

Acquisition will supercharge DoorDash’s grocery delivery, ‘one of the hardest things to get right online’, CEO says

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Oct 29 • 9:41 AM EDT • Business • theguardian.com
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Kawhi Leonard breaks silence on NBA fine after Clippers investigation

The superstar forward addresses his six-figure penalty as Toronto moves past a massive league investigation, focusing on a championship run alongside Scottie Barnes and RJ Barrett.

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Oct 24 • 11:16 PM EDT • Sports • sports.yahoo.com
Revealed: Full Men's Ballon d'Or top 10 rankings

Bayern Munich superstar Harry Kane was crowned the winner of the 2026 Ballon d’Or in London on Monday night.The full top 10 has now been announced, showing that the 33-year-old England captain finis...

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Oct 26 • 7:31 PM EDT • Sports • sports.yahoo.com
Native Housing: USDA Supports Tribal Home Loans

Six Native CDFIs will receive $6.18 million in USDA financing to support 43 home purchase loans and 25 home repair loans across six states.

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Oct 27 • 8:23 AM EDT • Business • tribalbusinessnews.com
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'That goes beyond party': Democrat superintendent candidate Jennettie Marshall talks priorities, politics

The Oklahoma general election is days away, and education issues are at the top of voters' minds. StateImpact's Beth Wallis sat down with the Democratic nominee for state superintendent, Jennettie Marshall. Marshall is a pastor and former Tulsa Public Schools board member.

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Oct 29 • 4:26 AM EDT • Politics • kosu.org
NFL-Jay-Z to headline next year's Super Bowl halftime show

LOS ANGELES, Oct 26 (Reuters) - Jay-Z will headline the 2027 Super Bowl halftime show in February, the National Football League announced on Monday.

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Oct 26 • 10:22 PM EDT • Entertainment • centraloregondaily.com
He's competed in 21 Hyrox races around the world: 3 top host cities

Lau Wen Loong has been competing in Hyrox races for two years and feels super fit. "I never imagined I could be faster than my younger self."

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Oct 25 • 8:30 PM EDT • Business • businessinsider.com
3 players Bears must target at 2026 NFL trade deadline

The Chicago Bears believe they are a team that has a chance to make a deep run in the postseason and earn a spot in the Super Bowl. They have certainly flashed their big-play ability in each of the last two seasons with Caleb Williams at quarterback, and they appear to have the offensive tools they need with receivers Rome Odunze, Luther Burden and […] The post 3 players Bears must target at 2026 NFL trade deadline appeared first on ClutchPoints.

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Oct 28 • 12:15 AM EDT • Sports • sports.yahoo.com
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Aday Mara Reflects On Early Stages of NBA Career

From watching idols on television to battling them on the court, the Thunder rookie describes the surreal experience of debuting against superstars Victor Wembanyama and Nikola Jokic.

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Oct 27 • 7:00 AM EDT • Sports • sports.yahoo.com
Skeleton Festival returns with ghosts, superheroes and family fun

Downtown Harrisonburg was covered with fantasy creatures like dragons, superheroes and princesses Saturday afternoon during the annual Skeleton Festival.

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Oct 25 • 7:00 AM EDT • Entertainment • dnronline.com
North Carolina flag football rankings: USA TODAY Sports Super 10, Week 8

In North Carolina's final regular season rankings, these teams sit atop this week’s Super 10 flag football rankings.

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Oct 27 • 11:11 AM EDT • Sports • sports.yahoo.com
Bayern bosses offer differing assessments of Lennart Karl’s development

Bayern Munich honorary president and supervisory board member Uli Hoeneß has spoken strongly about Lennart Karl, insisting that the highly rated youngster is still far from being a superstar. In an i...

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Oct 25 • 4:15 AM EDT • Sports • sports.yahoo.com
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Jay-Z to headline Super Bowl LXI halftime show at SoFi Stadium, NFL announces

Jay-Z's Roc Nation has had a deal with the NFL since 2019 to produce the Super Bowl halftime show.

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Oct 26 • 9:55 PM EDT • Sports • sports.yahoo.com
The Science Behind Jalen Hurts’ Controversial Blood Clot Diagnosis Is More Complicated Than It Looks

The Philadelphia Eagles quarterback played with a “superficial” blood clot that turned into something much more serious. Where did things go wrong?

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Oct 28 • 9:00 AM EDT • Science • popularmechanics.com
When does “High Potential” season 3 premiere? All about its Super Bowl special and cast shakeup

The cases aren’t closed... yet.

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Oct 27 • 2:47 PM EDT • Entertainment • yahoo.com
High school football rankings: USA TODAY Sports Super 15 East Region rankings, Week 11

After an upset loss to St. Peter's Prep, Don Bosco relinquishes their New Jersey crown this week.

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Oct 26 • 12:51 PM EDT • Sports • sports.yahoo.com